Growth in chick chorioallantoic membranes of strains of Newcastle disease virus of differing virulence.
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Your vote was cast
Thank you for your feedback
Thank you for your feedback
Journal titleThe Journal of hygiene
Publication Begin page61
Publication End page9
MetadataShow full item record
AbstractThe growth of eight strains of Newcastle disease virus in chick embryo chorioallantoic membranes was studied by comparing, at different times after infection, the amounts of haemagglutinin released into the allantoic fluid (extracellular haemagglutinin) with that associated with the membrane (cell-associated haemagglutinin). The virulence of the strains examined differed in that some killed chick embryos more rapidly than others. All strains released similar amounts of extracellular haemagglutinin and maximum titres were achieved about 12 hr. after infection. With virulent strains cell-associated haemagglutinin titres increased exponentially until the death of the host and maximum titres were much higher than those of extracellular haemagglutinin. With avirulent strains cell-associated haemagglutinin titres increased exponentially for only a limited time and titres were always lower than the titres of extracellular haemagglutinin.Similar results were obtained when the titres of neuraminidase and viral ribo-nucleoprotein were measured during the growth of two virulent and two avirulent strains. Virulence appears to be associated with the continued intracellular accumulation of viral antigens.
CitationReeve P, Rosenblum M, Alexander DJ. Growth in chick chorioallantoic membranes of strains of Newcastle disease virus of differing virulence. J Hyg (Lond). 1970 Mar;68(1):61-9. doi: 10.1017/s0022172400028503. PMID: 5266587; PMCID: PMC2130785.
The following license files are associated with this item:
- Creative Commons
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivatives 4.0 International
- The spread of a pathogenic and an apathogenic strain of Newcastle disease virus in the chick embryo as depending on the protease sensitivity of the virus glycoproteins.
- Authors: Nagai Y, Shimokata K, Yoshida T, Hamaguchi M, Iinuma M, Maeno K, Matsumoto T, Klenk HD, Rott R
- Issue date: 1979 Nov
- The proteins of Newcastle disease virus. 1. Structural proteins.
- Authors: Alexander DJ, Reeve P
- Issue date: 1972 May-Jun
- Subunits of NDV. Hemagglutinin and neuraminidase subunits of Newcastle disease virus.
- Authors: Iinuma M, Yoshida T, Nagai Y, Maeno K, Matsumoto T
- Issue date: 1971 Dec
- Virulence and in-vitro characteristics of four mutants of Newcastle disease virus.
- Authors: Schloer GM, Hanson RP
- Issue date: 1971 Sep
- Characterization of isolates of Newcastle disease virus from migratory birds and turkeys.
- Authors: Vickers ML, Hanson RP
- Issue date: 1982 Jan-Mar