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Journal titleFertility and sterility
Publication Begin page1142
Publication End page8
MetadataShow full item record
AbstractTo describe gonadal dysfunction and evaluate polycystic ovary syndrome (PCOS) and its association with metabolic syndrome (MeS) among girls in a morbidly obese adolescent population.
In a cross-sectional study of 174 girls, height, weight, waist circumference, Tanner stage, reproductive hormones, carbohydrate and lipid markers, drug use, and menstrual history were obtained at baseline. Exclusion criteria were menarcheal age <2 years, hormonal contraceptive or metformin use, Tanner stage <4, and incomplete data on PCOS or MeS classification.
University medical center outpatient clinic.
Ninety-eight girls ages 13-19.6 years, Tanner 5, average body mass index of 46.6 kg/m(2), menarche at 11.4 years, and average menarcheal age of 5 years.
Polycystic ovary syndrome and MeS.
Ninety-eight girls were divided into four groups: PCOS by National Institutes of Health criteria (PCOSN, n = 24), irregular menses only (n = 25), elevated T (≥55 ng/dL) only (n = 6), and obese controls (n = 43). Metabolic syndrome by modified Cook criteria affected 32 girls or 33% overall: 6 of 24 PCOSN, 7 of 25 irregular menses only, 4 of 6 elevated T only, and 15 of 43 obese controls. Polycystic ovary syndrome by National Institutes of Health criteria and its individual components were not associated with MeS after adjusting for body mass index.
Unlike obese adults, PCOSN and its individual components were not associated with MeS in the untreated morbidly obese adolescent population.
CitationChin V, Censani M, Lerner S, Conroy R, Oberfield S, McMahon D, Zitsman J, Fennoy I. Gonadal dysfunction in morbidly obese adolescent girls. Fertil Steril. 2014 Apr;101(4):1142-8. doi: 10.1016/j.fertnstert.2013.12.046. Epub 2014 Feb 26. PMID: 24581575; PMCID: PMC3972289.
The following license files are associated with this item:
- Creative Commons
Except where otherwise noted, this item's license is described as Copyright © 2014 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.
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