Alterations in Glucose Effectiveness and Insulin Dynamics: Polycystic Ovary Syndrome or Body Mass Index.
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Author
Vuguin, PatriciaSopher, Aviva B
Roumimper, Hailey
Chin, Vivian
Silfen, Miriam
McMahon, Donald J
Fennoy, Ilene
Oberfield, Sharon E
Keyword
Glucose effectivenessInsulin resistance
Metabolic dysregulation
Metabolic syndrome
Polycystic ovary syndrome in adolescents
Journal title
Hormone research in paediatricsDate Published
2017-05-05Publication Volume
87Publication Issue
6Publication Begin page
359Publication End page
367
Metadata
Show full item recordAbstract
To delineate the relationship of polycystic ovary syndrome (PCOS), obesity, and hyperandrogenism (HA) with glucose and insulin dynamics in adolescents across a broad body mass index (BMI).Seventy-four PCOS subjects (aged 16 years) and 82 controls (aged 16 years) were evaluated by an oral glucose tolerance test. Subjects were categorized by BMI: normal weight (21 ± 0.4), overweight/obesity (OO; 33 ± 1.0), and severe obesity (SO; 48 ± 1.4). Indices of glucose and insulin dynamics were determined. Multiple linear regression analysis was used to evaluate the contribution of PCOS, HA, and BMI to these indices.
BMI was significantly associated with systolic and diastolic blood pressure and insulin resistance. A significant interaction between BMI and PCOS and indices of post-glucose load was observed. The mean difference in peak glucose, early glucose response, area under the curve for glucose, and glucose effectiveness (SgIo) between PCOS and control subjects was significantly different between OO and SO. In PCOS subjects, testosterone was positively associated with BMI, fasting insulin, early insulin response, and diastolic blood pressure, and negatively associated with SgIo.
Abnormal glucose dynamics in adolescents with PCOS is mainly due to SO. The combination of PCOS and SO has a synergistic effect on glucose dynamics when compared to all other groups.
Citation
Vuguin P, Sopher AB, Roumimper H, Chin V, Silfen M, McMahon DJ, Fennoy I, Oberfield SE. Alterations in Glucose Effectiveness and Insulin Dynamics: Polycystic Ovary Syndrome or Body Mass Index. Horm Res Paediatr. 2017;87(6):359-367. doi: 10.1159/000471804. Epub 2017 May 5. PMID: 28478437; PMCID: PMC5914159.DOI
10.1159/000471804ae974a485f413a2113503eed53cd6c53
10.1159/000471804
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- Creative Commons
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