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dc.contributor.authorKochummen, Elna
dc.contributor.authorUmpaichitra, Vatcharapan
dc.contributor.authorMarwa, Albara
dc.contributor.authorJoshi, Krittika
dc.contributor.authorChin, Vivian L
dc.contributor.authorPerez-Colon, Sheila
dc.date.accessioned2023-05-12T16:51:05Z
dc.date.available2023-05-12T16:51:05Z
dc.date.issued2019-12-29
dc.identifier.citationKochummen E, Umpaichitra V, Marwa A, Joshi K, Chin VL, Perez-Colon S. Assessment of Microvascular Function in Children and Adolescents with Diabetes and Obesity. Int J Endocrinol Metab. 2019 Dec 29;18(1):e90094. doi: 10.5812/ijem.90094. PMID: 32308696; PMCID: PMC7138597.en_US
dc.identifier.issn1726-913X
dc.identifier.doi10.5812/ijem.90094
dc.identifier.pmid32308696
dc.identifier.urihttp://hdl.handle.net/20.500.12648/8696
dc.description.abstractEndothelial dysfunction (ED) is a marker of vascular damage. Glycated hemoglobin (A1C) predicts vascular complications. The EndoPAT (peripheral arterial tonometry) device calculates the reactive hyperemic index (RHI), a measure of endothelial function. The greater the vasodilation, the higher the RHI. We hypothesized that children with poorly-controlled diabetes mellitus (DM) and non-diabetes mellitus (NDM) obese children have ED.
dc.description.abstractA cross-sectional study using the EndoPAT device was performed on children with poorly-controlled DM and NDM children. ANOVA, -test, Mann-Whitney U test, multiple linear regression and Spearman correlation were used.
dc.description.abstractOf 58 children that completed the study (aged 13.1 ± 3.42 years), 33 with type 1 diabetes (T1DM), 8 with type 2 diabetes (T2DM) and 17 were NDM obese children. Eighty-five percent were African-American, 60% were female and 79% entered puberty. The RHI of children with DM (1.42 ± 0.48) versus NDM obese group (1.40 ± 0.34) was not different (P = 0.86) regardless of the type of DM or body mass index. In the DM group, for every 1% increase in latest A1C, the RHI decreased by 0.097 (P = 0.01) after adjusting for age, gender, and type of DM. The RHI of DM patients with latest A1C of < 10% (1.70 ± 0.58) versus those with A1C ≥10% (1.21 ± 0.19) was statistically different (P = 0.02). In the total study population, males had significantly lower RHI (1.28 ± 0.36) when compared to females (1.51 ± 0.46), P = 0.04 but this difference disappeared when considering pubertal status and type of diabetes.
dc.description.abstractOur data showed that patients with poorly-controlled DM as reflected by latest A1C of ≥ 10% had worse endothelial function as reflected by lower RHI score.
dc.language.isoenen_US
dc.relation.urlhttps://brieflands.com/articles/ijem-90094.htmlen_US
dc.rightsCopyright © 2019, International Journal of Endocrinology and Metabolism.
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectChildrenen_US
dc.subjectDiabetesen_US
dc.subjectEndothelial Dysfunctionen_US
dc.subjectObeseen_US
dc.subjectReactive Hyperemic Indexen_US
dc.titleAssessment of Microvascular Function in Children and Adolescents with Diabetes and Obesity.en_US
dc.typeArticle/Reviewen_US
dc.source.journaltitleInternational journal of endocrinology and metabolismen_US
dc.source.volume18
dc.source.issue1
dc.source.beginpagee90094
dc.source.endpage
dc.source.countryNetherlands
dc.description.versionVoRen_US
refterms.dateFOA2023-05-12T16:51:05Z
html.description.abstractEndothelial dysfunction (ED) is a marker of vascular damage. Glycated hemoglobin (A1C) predicts vascular complications. The EndoPAT (peripheral arterial tonometry) device calculates the reactive hyperemic index (RHI), a measure of endothelial function. The greater the vasodilation, the higher the RHI. We hypothesized that children with poorly-controlled diabetes mellitus (DM) and non-diabetes mellitus (NDM) obese children have ED.
html.description.abstractA cross-sectional study using the EndoPAT device was performed on children with poorly-controlled DM and NDM children. ANOVA, -test, Mann-Whitney U test, multiple linear regression and Spearman correlation were used.
html.description.abstractOf 58 children that completed the study (aged 13.1 ± 3.42 years), 33 with type 1 diabetes (T1DM), 8 with type 2 diabetes (T2DM) and 17 were NDM obese children. Eighty-five percent were African-American, 60% were female and 79% entered puberty. The RHI of children with DM (1.42 ± 0.48) versus NDM obese group (1.40 ± 0.34) was not different (P = 0.86) regardless of the type of DM or body mass index. In the DM group, for every 1% increase in latest A1C, the RHI decreased by 0.097 (P = 0.01) after adjusting for age, gender, and type of DM. The RHI of DM patients with latest A1C of < 10% (1.70 ± 0.58) versus those with A1C ≥10% (1.21 ± 0.19) was statistically different (P = 0.02). In the total study population, males had significantly lower RHI (1.28 ± 0.36) when compared to females (1.51 ± 0.46), P = 0.04 but this difference disappeared when considering pubertal status and type of diabetes.
html.description.abstractOur data showed that patients with poorly-controlled DM as reflected by latest A1C of ≥ 10% had worse endothelial function as reflected by lower RHI score.
dc.description.institutionSUNY Downstateen_US
dc.description.departmentPediatrics, Division of Pediatric Endocrinologyen_US
dc.description.degreelevelN/Aen_US
dc.identifier.journalInternational journal of endocrinology and metabolism


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Copyright © 2019, International Journal of Endocrinology and Metabolism.
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