Association of parental divorce, discord, and polygenic risk with children's alcohol initiation and lifetime risk for alcohol use disorder.
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AuthorKuo, Sally I-Chun
Thomas, Nathaniel S
Bucholz, Kathleen K
Dick, Danielle M
McCutcheon, Vivia V
Meyers, Jacquelyn L
Kramer, John R
Plawecki, Martin H
Salvatore, Jessica E
Journal titleAlcoholism, clinical and experimental research
Publication Begin page724
Publication End page735
MetadataShow full item record
AbstractParental divorce and discord are associated with poorer alcohol-related outcomes for offspring. However, not all children exposed to these stressors develop alcohol problems. Our objective was to test gene-by-environment interaction effects whereby children's genetic risk for alcohol problems modifies the effects of parental divorce and discord to predict alcohol outcomes.
The sample included European (EA; N = 5608, 47% male, M ~ 36 years) and African (AA; N = 1714, 46% female, M ~ 33 years) ancestry participants from the Collaborative Study on the Genetics of Alcoholism. Outcomes included age at initiation of regular drinking and lifetime DSM-5 alcohol use disorder (AUD). Predictors included parental divorce, parental relationship discord, and offspring alcohol problems polygenic risk scores (PRS ). Mixed effects Cox proportional hazard models were used to examine alcohol initiation and generalized linear mixed effects models were used to examine lifetime AUD. Tests of PRS moderation of the effects of parental divorce/relationship discord on alcohol outcomes were examined on multiplicative and additive scales.
Among EA participants, parental divorce, parental discord, and higher PRS were associated with earlier alcohol initiation and greater lifetime AUD risk. Among AA participants, parental divorce was associated with earlier alcohol initiation and discord was associated with earlier initiation and AUD. PRS was not associated with either. Parental divorce/discord and PRS interacted on an additive scale in the EA sample, but no interactions were found in AA participants.
Children's genetic risk for alcohol problems modifies the impact of parental divorce/discord, consistent with an additive model of diathesis-stress interaction, with some differences across ancestry.
CitationKuo SI, Thomas NS, Aliev F, Bucholz KK, Dick DM, McCutcheon VV, Meyers JL, Chan G, Kamarajan C, Kramer JR, Hesselbrock V, Plawecki MH, Porjesz B, Tischfield J, Salvatore JE. Association of parental divorce, discord, and polygenic risk with children's alcohol initiation and lifetime risk for alcohol use disorder. Alcohol Clin Exp Res. 2023 Apr;47(4):724-735. doi: 10.1111/acer.15042. Epub 2023 Mar 5. PMID: 36807915; PMCID: PMC10149624.
The following license files are associated with this item:
- Creative Commons
Except where otherwise noted, this item's license is described as © 2023 The Authors. Alcohol: Clinical and Experimental Research published by Wiley Periodicals LLC on behalf of Research Society on Alcohol.
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