Name:
Publisher version
View Source
Access full-text PDFOpen Access
View Source
Check access options
Check access options
Average rating
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Star rating
Your vote was cast
Thank you for your feedback
Thank you for your feedback
Journal title
Drug discovery today. Disease modelsDate Published
2017-03-31Publication Volume
19Publication Begin page
51Publication End page
57
Metadata
Show full item recordAbstract
Dystonia is a movement disorder that produces involuntary muscle contractions. Current pharmacological treatments are of limited efficacy. Dystonia, like epilepsy is a disorder involving excessive activty of motor areas including motor cortex and several causal gene mutations have been identified. In order to evaluate potential novel agents for multitarget therapy for dystonia, we have developed a computer model of cortex that includes some of the complex array of molecular interactions that, along with membrane ion channels, control cell excitability.Citation
Neymotin SA, Dura-Bernal S, Moreno H, Lytton WW. Computer modeling for pharmacological treatments for dystonia. Drug Discov Today Dis Models. 2016 Spring;19:51-57. doi: 10.1016/j.ddmod.2017.02.003. Epub 2017 Mar 31. PMID: 28983321; PMCID: PMC5624716.DOI
10.1016/j.ddmod.2017.02.003ae974a485f413a2113503eed53cd6c53
10.1016/j.ddmod.2017.02.003
Scopus Count
Collections
The following license files are associated with this item:
- Creative Commons
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivatives 4.0 International
Related articles
- Multitarget Multiscale Simulation for Pharmacological Treatment of Dystonia in Motor Cortex.
- Authors: Neymotin SA, Dura-Bernal S, Lakatos P, Sanger TD, Lytton WW
- Issue date: 2016
- Chapter 33: the history of movement disorders.
- Authors: Lanska DJ
- Issue date: 2010
- Primate models of dystonia.
- Authors: Guehl D, Cuny E, Ghorayeb I, Michelet T, Bioulac B, Burbaud P
- Issue date: 2009 Feb
- On Denny-Brown's 'spastic dystonia' - What is it and what causes it?
- Authors: Lorentzen J, Pradines M, Gracies JM, Bo Nielsen J
- Issue date: 2018 Jan
- [A patient with focal dystonia induced by golf and presenting a decrease in activity of cerebral motor cortex on task].
- Authors: Tanaka M, Ohyagi Y, Kawajiri M, Taniwaki T, Tobimatsu S, Furuya H, Yoshiura T, Kira J
- Issue date: 2005 Apr