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dc.contributor.authorRiedel, Stefan
dc.contributor.authorMelendez, Johan H
dc.contributor.authorAn, Amanda T
dc.contributor.authorRosenbaum, Janet E
dc.contributor.authorZenilman, Jonathan M
dc.date.accessioned2023-03-01T20:03:11Z
dc.date.available2023-03-01T20:03:11Z
dc.identifier.citationRiedel S, Melendez JH, An AT, Rosenbaum JE, Zenilman JM. Procalcitonin as a marker for the detection of bacteremia and sepsis in the emergency department. Am J Clin Pathol. 2011 Feb;135(2):182-9. doi: 10.1309/AJCP1MFYINQLECV2. PMID: 21228358.en_US
dc.identifier.eissn1943-7722
dc.identifier.doi10.1309/AJCP1MFYINQLECV2
dc.identifier.pmid21228358
dc.identifier.urihttp://hdl.handle.net/20.500.12648/8443
dc.description.abstractRapid diagnosis of bloodstream infections (BSIs) in the emergency department (ED) is challenging, with turnaround times exceeding the timeline for rapid diagnosis. We studied the usefulness of procalcitonin as a marker of BSI in 367 adults admitted to our ED with symptoms of systemic infection. Serum samples obtained at the same time as blood cultures were available from 295 patients. Procalcitonin levels were compared with blood culture results and other clinical data obtained during the ED visit. Procalcitonin levels of less than 0.1 ng/mL were considered negative; all other levels were considered positive. In 16 patients, there was evidence of BSI by blood culture, and 12 (75%) of 16 patients had a procalcitonin level of more than 0.1 ng/mL. In 186 (63.1%) of 295 samples, procalcitonin values were less than 0.1 ng/mL, and all were culture negative. With a calculated threshold of 0.1475 ng/mL for procalcitonin, sensitivity and specificity for the procalcitonin assay were 75% and 79%, respectively. The positive predictive value was 17% and the negative predictive value 98% compared with blood cultures. Procalcitonin is a useful marker to rule out sepsis and systemic inflammation in the ED.
dc.language.isoenen_US
dc.relation.urlhttps://academic.oup.com/ajcp/article/135/2/182/1760294en_US
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.titleProcalcitonin as a marker for the detection of bacteremia and sepsis in the emergency department.en_US
dc.typeArticle/Reviewen_US
dc.source.journaltitleAmerican journal of clinical pathologyen_US
dc.source.volume135
dc.source.issue2
dc.source.beginpage182
dc.source.endpage9
dc.source.countryEngland
dc.description.versionVoRen_US
refterms.dateFOA2023-03-01T20:03:11Z
html.description.abstractRapid diagnosis of bloodstream infections (BSIs) in the emergency department (ED) is challenging, with turnaround times exceeding the timeline for rapid diagnosis. We studied the usefulness of procalcitonin as a marker of BSI in 367 adults admitted to our ED with symptoms of systemic infection. Serum samples obtained at the same time as blood cultures were available from 295 patients. Procalcitonin levels were compared with blood culture results and other clinical data obtained during the ED visit. Procalcitonin levels of less than 0.1 ng/mL were considered negative; all other levels were considered positive. In 16 patients, there was evidence of BSI by blood culture, and 12 (75%) of 16 patients had a procalcitonin level of more than 0.1 ng/mL. In 186 (63.1%) of 295 samples, procalcitonin values were less than 0.1 ng/mL, and all were culture negative. With a calculated threshold of 0.1475 ng/mL for procalcitonin, sensitivity and specificity for the procalcitonin assay were 75% and 79%, respectively. The positive predictive value was 17% and the negative predictive value 98% compared with blood cultures. Procalcitonin is a useful marker to rule out sepsis and systemic inflammation in the ED.
dc.description.institutionSUNY Downstateen_US
dc.description.departmentEpidemiology and Biostatisticsen_US
dc.description.degreelevelN/Aen_US
dc.identifier.journalAmerican journal of clinical pathology


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