Blood pressure in children with sickle cell disease is higher than in the general pediatric population.
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Author
Kupferman, Juan CRosenbaum, Janet E
Lande, Marc B
Stabouli, Stella
Wang, Yongsheng
Forman, Daniella
Zafeiriou, Dimitrios I
Pavlakis, Steven G
Journal title
BMC pediatricsDate Published
2022-09-15Publication Volume
22Publication Issue
1Publication Begin page
549
Metadata
Show full item recordAbstract
Sickle cell disease (SCD) is associated with an increased risk of cardiovascular disease that may be due to a variety of possible risk factors, including abnormal blood pressure. Blood pressure (BP) of children and adolescents with SCD has been reported to be lower compared to the BP of the general pediatric population.To confirm this prior observation, we compared reference BP values for children with SCD with reference BP values of the general pediatric population. We hypothesized that children with SCD do not have lower BPs than children without SCD.
Systolic BP differed for both males and females, over the different age groups between pediatric subjects with and without SCD. Systolic BP was higher in children with SCD, in both obese and non-obese populations. Diastolic BP did not differ between the groups.
Our analysis demonstrated that systolic BP values are indeed higher in children with SCD than in the general pediatric population. This finding is consistent with the most recent literature showing abnormal BP patterns in the SCD pediatric population utilizing 24-hour BP monitoring devices. This is an important step for recognizing abnormal BP as a risk factor for cardio- and neurovascular events in SCD.
Citation
Kupferman JC, Rosenbaum JE, Lande MB, Stabouli S, Wang Y, Forman D, Zafeiriou DI, Pavlakis SG. Blood pressure in children with sickle cell disease is higher than in the general pediatric population. BMC Pediatr. 2022 Sep 15;22(1):549. doi: 10.1186/s12887-022-03584-9. PMID: 36109730; PMCID: PMC9476310.DOI
10.1186/s12887-022-03584-9ae974a485f413a2113503eed53cd6c53
10.1186/s12887-022-03584-9
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- Creative Commons
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