Can a basic solution activate the inflammatory reflex? A review of potential mechanisms, opportunities, and challenges.
| dc.contributor.author | Alvarez, Milena Rodriguez | |
| dc.contributor.author | Alarcon, Juan Marcos | |
| dc.contributor.author | Roman, Christopher A | |
| dc.contributor.author | Lazaro, Deana | |
| dc.contributor.author | Bobrowski-Khoury, Natasha | |
| dc.contributor.author | Baena-Caldas, Gloria Patricia | |
| dc.contributor.author | Esber, Guillem R | |
| dc.date.accessioned | 2023-03-01T17:53:43Z | |
| dc.date.available | 2023-03-01T17:53:43Z | |
| dc.date.issued | 2022-10-28 | |
| dc.identifier.citation | Alvarez MR, Alarcon JM, Roman CA, Lazaro D, Bobrowski-Khoury N, Baena-Caldas GP, Esber GR. Can a basic solution activate the inflammatory reflex? A review of potential mechanisms, opportunities, and challenges. Pharmacol Res. 2023 Jan;187:106525. doi: 10.1016/j.phrs.2022.106525. Epub 2022 Oct 28. PMID: 36441036. | en_US |
| dc.identifier.eissn | 1096-1186 | |
| dc.identifier.doi | 10.1016/j.phrs.2022.106525 | |
| dc.identifier.pmid | 36441036 | |
| dc.identifier.uri | http://hdl.handle.net/20.500.12648/8411 | |
| dc.description.abstract | Stimulation of the inflammatory reflex (IR) is a promising strategy to treat systemic inflammatory disorders. However, this strategy is hindered by the cost and side effects of traditional IR activators. Recently, oral intake of sodium bicarbonate (NaHCO3) has been suggested to activate the IR, providing a safe and inexpensive alternative. Critically, the mechanisms whereby NaHCO3 might achieve this effect and more broadly the pathways underlying the IR remain poorly understood. Here, we argue that the recognition of NaHCO3 as a potential IR activator presents exciting clinical and research opportunities. To aid this quest, we provide an integrative review of our current knowledge of the neural and cellular pathways mediating the IR and discuss the status of physiological models of IR activation. From this vantage point, we derive testable hypotheses on potential mechanisms whereby NaHCO3 might stimulate the IR and compare NaHCO3 with classic IR activators. Elucidation of these mechanisms will help determine the therapeutic value of NaHCO3 as an IR activator and provide new insights into the IR circuitry. | |
| dc.language.iso | en | en_US |
| dc.relation.url | https://www.sciencedirect.com/science/article/pii/S1043661822004716 | en_US |
| dc.rights | Copyright © 2022. Published by Elsevier Ltd. | |
| dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 International | * |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
| dc.subject | Cholinergic splenic anti-inflammatory pathway (CSAP) | en_US |
| dc.subject | Inflammatory reflex (IR) | en_US |
| dc.subject | Inflammatory reflex activators | en_US |
| dc.subject | Monocyte polarization | en_US |
| dc.subject | Sodium bicarbonate | en_US |
| dc.subject | Splanchnic anti-inflammatory pathways (SAP) | en_US |
| dc.subject | Splenic nerve | en_US |
| dc.subject | Systemic inflammation | en_US |
| dc.subject | Vagal nerve stimulation (VNS) | en_US |
| dc.title | Can a basic solution activate the inflammatory reflex? A review of potential mechanisms, opportunities, and challenges. | en_US |
| dc.type | Article/Review | en_US |
| dc.source.journaltitle | Pharmacological research | en_US |
| dc.source.volume | 187 | |
| dc.source.beginpage | 106525 | |
| dc.source.endpage | ||
| dc.source.country | United States | |
| dc.source.country | United States | |
| dc.source.country | United States | |
| dc.source.country | Netherlands | |
| dc.description.version | VoR | en_US |
| refterms.dateFOA | 2023-03-01T17:53:44Z | |
| html.description.abstract | Stimulation of the inflammatory reflex (IR) is a promising strategy to treat systemic inflammatory disorders. However, this strategy is hindered by the cost and side effects of traditional IR activators. Recently, oral intake of sodium bicarbonate (NaHCO3) has been suggested to activate the IR, providing a safe and inexpensive alternative. Critically, the mechanisms whereby NaHCO3 might achieve this effect and more broadly the pathways underlying the IR remain poorly understood. Here, we argue that the recognition of NaHCO3 as a potential IR activator presents exciting clinical and research opportunities. To aid this quest, we provide an integrative review of our current knowledge of the neural and cellular pathways mediating the IR and discuss the status of physiological models of IR activation. From this vantage point, we derive testable hypotheses on potential mechanisms whereby NaHCO3 might stimulate the IR and compare NaHCO3 with classic IR activators. Elucidation of these mechanisms will help determine the therapeutic value of NaHCO3 as an IR activator and provide new insights into the IR circuitry. | |
| dc.description.institution | SUNY Downstate | en_US |
| dc.description.department | Rheumatology | en_US |
| dc.description.degreelevel | N/A | en_US |
| dc.identifier.journal | Pharmacological research |
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