Can a basic solution activate the inflammatory reflex? A review of potential mechanisms, opportunities, and challenges.
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AuthorAlvarez, Milena Rodriguez
Alarcon, Juan Marcos
Roman, Christopher A
Baena-Caldas, Gloria Patricia
Esber, Guillem R
KeywordCholinergic splenic anti-inflammatory pathway (CSAP)
Inflammatory reflex (IR)
Inflammatory reflex activators
Splanchnic anti-inflammatory pathways (SAP)
Vagal nerve stimulation (VNS)
Journal titlePharmacological research
Publication Begin page106525
MetadataShow full item record
AbstractStimulation of the inflammatory reflex (IR) is a promising strategy to treat systemic inflammatory disorders. However, this strategy is hindered by the cost and side effects of traditional IR activators. Recently, oral intake of sodium bicarbonate (NaHCO3) has been suggested to activate the IR, providing a safe and inexpensive alternative. Critically, the mechanisms whereby NaHCO3 might achieve this effect and more broadly the pathways underlying the IR remain poorly understood. Here, we argue that the recognition of NaHCO3 as a potential IR activator presents exciting clinical and research opportunities. To aid this quest, we provide an integrative review of our current knowledge of the neural and cellular pathways mediating the IR and discuss the status of physiological models of IR activation. From this vantage point, we derive testable hypotheses on potential mechanisms whereby NaHCO3 might stimulate the IR and compare NaHCO3 with classic IR activators. Elucidation of these mechanisms will help determine the therapeutic value of NaHCO3 as an IR activator and provide new insights into the IR circuitry.
CitationAlvarez MR, Alarcon JM, Roman CA, Lazaro D, Bobrowski-Khoury N, Baena-Caldas GP, Esber GR. Can a basic solution activate the inflammatory reflex? A review of potential mechanisms, opportunities, and challenges. Pharmacol Res. 2023 Jan;187:106525. doi: 10.1016/j.phrs.2022.106525. Epub 2022 Oct 28. PMID: 36441036.
The following license files are associated with this item:
- Creative Commons
Except where otherwise noted, this item's license is described as Copyright © 2022. Published by Elsevier Ltd.
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