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dc.contributor.authorDocherty, Anna R
dc.contributor.authorEdwards, Alexis C
dc.contributor.authorYang, Fuzhong
dc.contributor.authorPeterson, Roseann E
dc.contributor.authorSawyers, Chelsea
dc.contributor.authorAdkins, Daniel E
dc.contributor.authorMoore, Ashlee A
dc.contributor.authorWebb, Bradley T
dc.contributor.authorBacanu, Silviu A
dc.contributor.authorFlint, Jonathan
dc.contributor.authorKendler, Kenneth S
dc.date.accessioned2023-02-22T17:12:01Z
dc.date.available2023-02-22T17:12:01Z
dc.date.issued2017-02-02
dc.identifier.citationDocherty AR, Edwards AC, Yang F, Peterson RE, Sawyers C, Adkins DE, Moore AA, Webb BT, Bacanu SA, Flint J, Kendler KS. Age of onset and family history as indicators of polygenic risk for major depression. Depress Anxiety. 2017 May;34(5):446-452. doi: 10.1002/da.22607. Epub 2017 Feb 2. PMID: 28152564; PMCID: PMC5501985.en_US
dc.identifier.eissn1520-6394
dc.identifier.doi10.1002/da.22607
dc.identifier.pmid28152564
dc.identifier.urihttp://hdl.handle.net/20.500.12648/8393
dc.description.abstractThe extent to which earlier age of onset (AO) is a reflection of increased genetic risk for major depression (MD) is still unknown. Previous biometrical research has provided mixed empirical evidence for the genetic overlap of AO with MD. If AO is demonstrated to be relevant to molecular polygenic risk for MD, incorporation of AO as a phenotype could enhance future genetic studies.
dc.description.abstractThis research estimated the SNP-based heritability of AO in the China, Oxford and VCU Experimental Research on Genetic Epidemiology (CONVERGE) case-control sample (N = 9,854; MD case, n = 4,927). Common single nucleotide polymorphism heritability of MD was also examined across both high and low median-split AO groups, and best linear unbiased predictor (BLUP) scores of polygenic risk, in split-halves, were used to predict AO. Distributions of genetic risk across early and late AO were compared, and presence of self-reported family history (FH) of MD was also examined as a predictor of AO.
dc.description.abstractAO was not significantly heritable and polygenic risk derived from the aggregated effects of common genetic variants did not significantly predict AO in any analysis. AO was modestly but significantly lower in cases with a first-degree genetic FH of MD.
dc.description.abstractFindings indicate that AO is associated with greater self-reported genetic risk for MD in cases, yet not associated with common variant polygenic risk for MD. Future studies of early MD may benefit more from the examination of important moderating variables such as early life events.
dc.language.isoenen_US
dc.relation.urlhttps://onlinelibrary.wiley.com/doi/epdf/10.1002/da.22607en_US
dc.rights© 2017 Wiley Periodicals, Inc.
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectCONVERGEen_US
dc.subjectGCTAen_US
dc.subjectage of onseten_US
dc.subjectdepressionen_US
dc.subjectfamily historyen_US
dc.subjectgenomeen_US
dc.subjectgenome-wide complex trait analysisen_US
dc.titleAge of onset and family history as indicators of polygenic risk for major depression.en_US
dc.typeArticle/Reviewen_US
dc.source.journaltitleDepression and anxietyen_US
dc.source.volume34
dc.source.issue5
dc.source.beginpage446
dc.source.endpage452
dc.source.countryUnited Kingdom
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited Kingdom
dc.source.countryUnited Kingdom
dc.source.countryUnited Kingdom
dc.source.countryUnited States
dc.description.versionAMen_US
refterms.dateFOA2023-02-22T17:12:01Z
html.description.abstractThe extent to which earlier age of onset (AO) is a reflection of increased genetic risk for major depression (MD) is still unknown. Previous biometrical research has provided mixed empirical evidence for the genetic overlap of AO with MD. If AO is demonstrated to be relevant to molecular polygenic risk for MD, incorporation of AO as a phenotype could enhance future genetic studies.
html.description.abstractThis research estimated the SNP-based heritability of AO in the China, Oxford and VCU Experimental Research on Genetic Epidemiology (CONVERGE) case-control sample (N = 9,854; MD case, n = 4,927). Common single nucleotide polymorphism heritability of MD was also examined across both high and low median-split AO groups, and best linear unbiased predictor (BLUP) scores of polygenic risk, in split-halves, were used to predict AO. Distributions of genetic risk across early and late AO were compared, and presence of self-reported family history (FH) of MD was also examined as a predictor of AO.
html.description.abstractAO was not significantly heritable and polygenic risk derived from the aggregated effects of common genetic variants did not significantly predict AO in any analysis. AO was modestly but significantly lower in cases with a first-degree genetic FH of MD.
html.description.abstractFindings indicate that AO is associated with greater self-reported genetic risk for MD in cases, yet not associated with common variant polygenic risk for MD. Future studies of early MD may benefit more from the examination of important moderating variables such as early life events.
dc.description.institutionSUNY Downstateen_US
dc.description.departmentPsychiatry and Behavioral Sciencesen_US
dc.description.departmentInstitute for Genomics in Healthen_US
dc.description.degreelevelN/Aen_US
dc.identifier.journalDepression and anxiety


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