Polygenic risk for severe psychopathology among Europeans is associated with major depressive disorder in Han Chinese women.
Average rating
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Star rating
Your vote was cast
Thank you for your feedback
Thank you for your feedback
Author
Edwards, A CDocherty, A R
Moscati, A
Bigdeli, T B
Peterson, R E
Webb, B T
Bacanu, S-A
Hettema, J M
Flint, J
Kendler, K S
Journal title
Psychological medicineDate Published
2017-10-03Publication Volume
48Publication Issue
5Publication Begin page
777Publication End page
789
Metadata
Show full item recordAbstract
Previous studies have demonstrated that several major psychiatric disorders are influenced by shared genetic factors. This shared liability may influence clinical features of a given disorder (e.g. severity, age at onset). However, findings have largely been limited to European samples; little is known about the consistency of shared genetic liability across ethnicities.The relationship between polygenic risk for several major psychiatric diagnoses and major depressive disorder (MDD) was examined in a sample of unrelated Han Chinese women. Polygenic risk scores (PRSs) were generated using European discovery samples and tested in the China, Oxford, and VCU Experimental Research on Genetic Epidemiology [CONVERGE (maximum N = 10 502)], a sample ascertained for recurrent MDD. Genetic correlations between discovery phenotypes and MDD were also assessed. In addition, within-case characteristics were examined.
European-based polygenic risk for several major psychiatric disorder phenotypes was significantly associated with the MDD case status in CONVERGE. Risk for clinically significant indicators (neuroticism and subjective well-being) was also associated with case-control status. The variance accounted for by PRS for both psychopathology and for well-being was similar to estimates reported for within-ethnicity comparisons in European samples. However, European-based PRS were largely unassociated with CONVERGE family history, clinical characteristics, or comorbidity.
The shared genetic liability across severe forms of psychopathology is largely consistent across European and Han Chinese ethnicities, with little attenuation of genetic signal relative to within-ethnicity analyses. The overall absence of associations between PRS for other disorders and within-MDD variation suggests that clinical characteristics of MDD may arise due to contributions from ethnicity-specific factors and/or pathoplasticity.
Citation
Edwards AC, Docherty AR, Moscati A, Bigdeli TB, Peterson RE, Webb BT, Bacanu SA, Hettema JM, Flint J, Kendler KS. Polygenic risk for severe psychopathology among Europeans is associated with major depressive disorder in Han Chinese women. Psychol Med. 2018 Apr;48(5):777-789. doi: 10.1017/S0033291717002148. Epub 2017 Oct 3. PMID: 28969721; PMCID: PMC5843532.DOI
10.1017/S0033291717002148ae974a485f413a2113503eed53cd6c53
10.1017/S0033291717002148
Scopus Count
Collections
The following license files are associated with this item:
- Creative Commons
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivatives 4.0 International
Related articles
- SNP-based heritability estimates of the personality dimensions and polygenic prediction of both neuroticism and major depression: findings from CONVERGE.
- Authors: Docherty AR, Moscati A, Peterson R, Edwards AC, Adkins DE, Bacanu SA, Bigdeli TB, Webb BT, Flint J, Kendler KS
- Issue date: 2016 Oct 25
- Genetic effects influencing risk for major depressive disorder in China and Europe.
- Authors: Bigdeli TB, Ripke S, Peterson RE, Trzaskowski M, Bacanu SA, Abdellaoui A, Andlauer TF, Beekman AT, Berger K, Blackwood DH, Boomsma DI, Breen G, Buttenschøn HN, Byrne EM, Cichon S, Clarke TK, Couvy-Duchesne B, Craddock N, de Geus EJ, Degenhardt F, Dunn EC, Edwards AC, Fanous AH, Forstner AJ, Frank J, Gill M, Gordon SD, Grabe HJ, Hamilton SP, Hardiman O, Hayward C, Heath AC, Henders AK, Herms S, Hickie IB, Hoffmann P, Homuth G, Hottenga JJ, Ising M, Jansen R, Kloiber S, Knowles JA, Lang M, Li QS, Lucae S, MacIntyre DJ, Madden PA, Martin NG, McGrath PJ, McGuffin P, McIntosh AM, Medland SE, Mehta D, Middeldorp CM, Milaneschi Y, Montgomery GW, Mors O, Müller-Myhsok B, Nauck M, Nyholt DR, Nöthen MM, Owen MJ, Penninx BW, Pergadia ML, Perlis RH, Peyrot WJ, Porteous DJ, Potash JB, Rice JP, Rietschel M, Riley BP, Rivera M, Schoevers R, Schulze TG, Shi J, Shyn SI, Smit JH, Smoller JW, Streit F, Strohmaier J, Teumer A, Treutlein J, Van der Auwera S, van Grootheest G, van Hemert AM, Völzke H, Webb BT, Weissman MM, Wellmann J, Willemsen G, Witt SH, Levinson DF, Lewis CM, Wray NR, Flint J, Sullivan PF, Kendler KS
- Issue date: 2017 Mar 28
- Pathway-based polygene risk for severe depression implicates drug metabolism in CONVERGE.
- Authors: Docherty AR, Moscati A, Bigdeli TB, Edwards AC, Peterson RE, Adkins DE, Anderson JS, Flint J, Kendler KS, Bacanu SA
- Issue date: 2020 Apr
- Polygenic Scores for Major Depressive Disorder and Risk of Alcohol Dependence.
- Authors: Andersen AM, Pietrzak RH, Kranzler HR, Ma L, Zhou H, Liu X, Kramer J, Kuperman S, Edenberg HJ, Nurnberger JI Jr, Rice JP, Tischfield JA, Goate A, Foroud TM, Meyers JL, Porjesz B, Dick DM, Hesselbrock V, Boerwinkle E, Southwick SM, Krystal JH, Weissman MM, Levinson DF, Potash JB, Gelernter J, Han S
- Issue date: 2017 Nov 1
- Differential associations of depression-related phenotypes with cardiometabolic risks: Polygenic analyses and exploring shared genetic variants and pathways.
- Authors: Wong BC, Chau CK, Ao FK, Mo CH, Wong SY, Wong YH, So HC
- Issue date: 2019 Apr