Polygenic prediction of the phenome, across ancestry, in emerging adulthood.
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Author
Docherty, Anna RMoscati, Arden
Dick, Danielle
Savage, Jeanne E
Salvatore, Jessica E
Cooke, Megan
Aliev, Fazil
Moore, Ashlee A
Edwards, Alexis C
Riley, Brien P
Adkins, Daniel E
Peterson, Roseann
Webb, Bradley T
Bacanu, Silviu A
Kendler, Kenneth S
Journal title
Psychological medicineDate Published
2017-11-27Publication Volume
48Publication Issue
11Publication Begin page
1814Publication End page
1823
Metadata
Show full item recordAbstract
Identifying genetic relationships between complex traits in emerging adulthood can provide useful etiological insights into risk for psychopathology. College-age individuals are under-represented in genomic analyses thus far, and the majority of work has focused on the clinical disorder or cognitive abilities rather than normal-range behavioral outcomes.This study examined a sample of emerging adults 18-22 years of age (N = 5947) to construct an atlas of polygenic risk for 33 traits predicting relevant phenotypic outcomes. Twenty-eight hypotheses were tested based on the previous literature on samples of European ancestry, and the availability of rich assessment data allowed for polygenic predictions across 55 psychological and medical phenotypes.
Polygenic risk for schizophrenia (SZ) in emerging adults predicted anxiety, depression, nicotine use, trauma, and family history of psychological disorders. Polygenic risk for neuroticism predicted anxiety, depression, phobia, panic, neuroticism, and was correlated with polygenic risk for cardiovascular disease.
These results demonstrate the extensive impact of genetic risk for SZ, neuroticism, and major depression on a range of health outcomes in early adulthood. Minimal cross-ancestry replication of these phenomic patterns of polygenic influence underscores the need for more genome-wide association studies of non-European populations.
Citation
Docherty AR, Moscati A, Dick D, Savage JE, Salvatore JE, Cooke M, Aliev F, Moore AA, Edwards AC, Riley BP, Adkins DE, Peterson R, Webb BT, Bacanu SA, Kendler KS. Polygenic prediction of the phenome, across ancestry, in emerging adulthood. Psychol Med. 2018 Aug;48(11):1814-1823. doi: 10.1017/S0033291717003312. Epub 2017 Nov 27. PMID: 29173193; PMCID: PMC5971142.DOI
10.1017/S0033291717003312ae974a485f413a2113503eed53cd6c53
10.1017/S0033291717003312
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Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivatives 4.0 International
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