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dc.contributor.authorPeterson, Roseann E
dc.contributor.authorCai, Na
dc.contributor.authorDahl, Andy W
dc.contributor.authorBigdeli, Tim B
dc.contributor.authorEdwards, Alexis C
dc.contributor.authorWebb, Bradley T
dc.contributor.authorBacanu, Silviu-Alin
dc.contributor.authorZaitlen, Noah
dc.contributor.authorFlint, Jonathan
dc.contributor.authorKendler, Kenneth S
dc.date.accessioned2023-02-15T19:57:29Z
dc.date.available2023-02-15T19:57:29Z
dc.date.issued2018-03-02
dc.identifier.citationPeterson RE, Cai N, Dahl AW, Bigdeli TB, Edwards AC, Webb BT, Bacanu SA, Zaitlen N, Flint J, Kendler KS. Molecular Genetic Analysis Subdivided by Adversity Exposure Suggests Etiologic Heterogeneity in Major Depression. Am J Psychiatry. 2018 Jun 1;175(6):545-554. doi: 10.1176/appi.ajp.2017.17060621. Epub 2018 Mar 2. PMID: 29495898; PMCID: PMC5988935.en_US
dc.identifier.eissn1535-7228
dc.identifier.doi10.1176/appi.ajp.2017.17060621
dc.identifier.pmid29495898
dc.identifier.urihttp://hdl.handle.net/20.500.12648/8375
dc.description.abstractThe extent to which major depression is the outcome of a single biological mechanism or represents a final common pathway of multiple disease processes remains uncertain. Genetic approaches can potentially identify etiologic heterogeneity in major depression by classifying patients on the basis of their experience of major adverse events.
dc.description.abstractData are from the China, Oxford, and VCU Experimental Research on Genetic Epidemiology (CONVERGE) project, a study of Han Chinese women with recurrent major depression aimed at identifying genetic risk factors for major depression in a rigorously ascertained cohort carefully assessed for key environmental risk factors (N=9,599). To detect etiologic heterogeneity, genome-wide association studies, heritability analyses, and gene-by-environment interaction analyses were performed.
dc.description.abstractGenome-wide association studies stratified by exposure to adversity revealed three novel loci associated with major depression only in study participants with no history of adversity. Significant gene-by-environment interactions were seen between adversity and genotype at all three loci, and 13.2% of major depression liability can be attributed to genome-wide interaction with adversity exposure. The genetic risk in major depression for participants who reported major adverse life events (27%) was partially shared with that in participants who did not (73%; genetic correlation=+0.64). Together with results from simulation studies, these findings suggest etiologic heterogeneity within major depression as a function of environmental exposures.
dc.description.abstractThe genetic contributions to major depression may differ between women with and those without major adverse life events. These results have implications for the molecular dissection of major depression and other complex psychiatric and biomedical diseases.
dc.language.isoenen_US
dc.relation.urlhttps://ajp.psychiatryonline.org/doi/10.1176/appi.ajp.2017.17060621en_US
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectDiagnosis and Classificationen_US
dc.subjectGeneticsen_US
dc.subjectMood Disorders-Unipolaren_US
dc.titleMolecular Genetic Analysis Subdivided by Adversity Exposure Suggests Etiologic Heterogeneity in Major Depression.en_US
dc.typeArticle/Reviewen_US
dc.source.journaltitleThe American journal of psychiatryen_US
dc.source.volume175
dc.source.issue6
dc.source.beginpage545
dc.source.endpage554
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited Kingdom
dc.source.countryUnited States
dc.source.countryUnited Kingdom
dc.source.countryUnited Kingdom
dc.source.countryUnited Kingdom
dc.source.countryUnited States
dc.description.versionAMen_US
refterms.dateFOA2023-02-15T19:57:29Z
html.description.abstractThe extent to which major depression is the outcome of a single biological mechanism or represents a final common pathway of multiple disease processes remains uncertain. Genetic approaches can potentially identify etiologic heterogeneity in major depression by classifying patients on the basis of their experience of major adverse events.
html.description.abstractData are from the China, Oxford, and VCU Experimental Research on Genetic Epidemiology (CONVERGE) project, a study of Han Chinese women with recurrent major depression aimed at identifying genetic risk factors for major depression in a rigorously ascertained cohort carefully assessed for key environmental risk factors (N=9,599). To detect etiologic heterogeneity, genome-wide association studies, heritability analyses, and gene-by-environment interaction analyses were performed.
html.description.abstractGenome-wide association studies stratified by exposure to adversity revealed three novel loci associated with major depression only in study participants with no history of adversity. Significant gene-by-environment interactions were seen between adversity and genotype at all three loci, and 13.2% of major depression liability can be attributed to genome-wide interaction with adversity exposure. The genetic risk in major depression for participants who reported major adverse life events (27%) was partially shared with that in participants who did not (73%; genetic correlation=+0.64). Together with results from simulation studies, these findings suggest etiologic heterogeneity within major depression as a function of environmental exposures.
html.description.abstractThe genetic contributions to major depression may differ between women with and those without major adverse life events. These results have implications for the molecular dissection of major depression and other complex psychiatric and biomedical diseases.
dc.description.institutionSUNY Downstateen_US
dc.description.departmentPsychiatry and Behavioral Sciencesen_US
dc.description.departmentInstitute for Genomics in Healthen_US
dc.description.degreelevelN/Aen_US
dc.identifier.journalThe American journal of psychiatry


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