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dc.contributor.authorWray, Naomi R
dc.contributor.authorRipke, Stephan
dc.contributor.authorMattheisen, Manuel
dc.contributor.authorTrzaskowski, Maciej
dc.contributor.authorByrne, Enda M
dc.contributor.authorAbdellaoui, Abdel
dc.contributor.authorAdams, Mark J
dc.contributor.authorAgerbo, Esben
dc.contributor.authorAir, Tracy M
dc.contributor.authorAndlauer, Till M F
dc.contributor.authorBacanu, Silviu-Alin
dc.contributor.authorBækvad-Hansen, Marie
dc.contributor.authorBeekman, Aartjan F T
dc.contributor.authorBigdeli, Tim B
dc.contributor.authorBinder, Elisabeth B
dc.contributor.authorBlackwood, Douglas R H
dc.contributor.authorBryois, Julien
dc.contributor.authorButtenschøn, Henriette N
dc.contributor.authorBybjerg-Grauholm, Jonas
dc.contributor.authorCai, Na
dc.contributor.authorCastelao, Enrique
dc.contributor.authorChristensen, Jane Hvarregaard
dc.contributor.authorClarke, Toni-Kim
dc.contributor.authorColeman, Jonathan I R
dc.contributor.authorColodro-Conde, Lucía
dc.contributor.authorCouvy-Duchesne, Baptiste
dc.contributor.authorCraddock, Nick
dc.contributor.authorCrawford, Gregory E
dc.contributor.authorCrowley, Cheynna A
dc.contributor.authorDashti, Hassan S
dc.contributor.authorDavies, Gail
dc.contributor.authorDeary, Ian J
dc.contributor.authorDegenhardt, Franziska
dc.contributor.authorDerks, Eske M
dc.contributor.authorDirek, Nese
dc.contributor.authorDolan, Conor V
dc.contributor.authorDunn, Erin C
dc.contributor.authorEley, Thalia C
dc.contributor.authorEriksson, Nicholas
dc.contributor.authorEscott-Price, Valentina
dc.contributor.authorKiadeh, Farnush Hassan Farhadi
dc.contributor.authorFinucane, Hilary K
dc.contributor.authorForstner, Andreas J
dc.contributor.authorFrank, Josef
dc.contributor.authorGaspar, Héléna A
dc.contributor.authorGill, Michael
dc.contributor.authorGiusti-Rodríguez, Paola
dc.contributor.authorGoes, Fernando S
dc.contributor.authorGordon, Scott D
dc.contributor.authorGrove, Jakob
dc.contributor.authorHall, Lynsey S
dc.contributor.authorHannon, Eilis
dc.contributor.authorHansen, Christine Søholm
dc.contributor.authorHansen, Thomas F
dc.contributor.authorHerms, Stefan
dc.contributor.authorHickie, Ian B
dc.contributor.authorHoffmann, Per
dc.contributor.authorHomuth, Georg
dc.contributor.authorHorn, Carsten
dc.contributor.authorHottenga, Jouke-Jan
dc.contributor.authorHougaard, David M
dc.contributor.authorHu, Ming
dc.contributor.authorHyde, Craig L
dc.contributor.authorIsing, Marcus
dc.contributor.authorJansen, Rick
dc.contributor.authorJin, Fulai
dc.contributor.authorJorgenson, Eric
dc.contributor.authorKnowles, James A
dc.contributor.authorKohane, Isaac S
dc.contributor.authorKraft, Julia
dc.contributor.authorKretzschmar, Warren W
dc.contributor.authorKrogh, Jesper
dc.contributor.authorKutalik, Zoltán
dc.contributor.authorLane, Jacqueline M
dc.contributor.authorLi, Yihan
dc.contributor.authorLi, Yun
dc.contributor.authorLind, Penelope A
dc.contributor.authorLiu, Xiaoxiao
dc.contributor.authorLu, Leina
dc.contributor.authorMacIntyre, Donald J
dc.contributor.authorMacKinnon, Dean F
dc.contributor.authorMaier, Robert M
dc.contributor.authorMaier, Wolfgang
dc.contributor.authorMarchini, Jonathan
dc.contributor.authorMbarek, Hamdi
dc.contributor.authorMcGrath, Patrick
dc.contributor.authorMcGuffin, Peter
dc.contributor.authorMedland, Sarah E
dc.contributor.authorMehta, Divya
dc.contributor.authorMiddeldorp, Christel M
dc.contributor.authorMihailov, Evelin
dc.contributor.authorMilaneschi, Yuri
dc.contributor.authorMilani, Lili
dc.contributor.authorMill, Jonathan
dc.contributor.authorMondimore, Francis M
dc.contributor.authorMontgomery, Grant W
dc.contributor.authorMostafavi, Sara
dc.contributor.authorMullins, Niamh
dc.contributor.authorNauck, Matthias
dc.contributor.authorNg, Bernard
dc.contributor.authorNivard, Michel G
dc.contributor.authorNyholt, Dale R
dc.contributor.authorO'Reilly, Paul F
dc.contributor.authorOskarsson, Hogni
dc.contributor.authorOwen, Michael J
dc.contributor.authorPainter, Jodie N
dc.contributor.authorPedersen, Carsten Bøcker
dc.contributor.authorPedersen, Marianne Giørtz
dc.contributor.authorPeterson, Roseann E
dc.contributor.authorPettersson, Erik
dc.contributor.authorPeyrot, Wouter J
dc.contributor.authorPistis, Giorgio
dc.contributor.authorPosthuma, Danielle
dc.contributor.authorPurcell, Shaun M
dc.contributor.authorQuiroz, Jorge A
dc.contributor.authorQvist, Per
dc.contributor.authorRice, John P
dc.contributor.authorRiley, Brien P
dc.contributor.authorRivera, Margarita
dc.contributor.authorSaeed Mirza, Saira
dc.contributor.authorSaxena, Richa
dc.contributor.authorSchoevers, Robert
dc.contributor.authorSchulte, Eva C
dc.contributor.authorShen, Ling
dc.contributor.authorShi, Jianxin
dc.contributor.authorShyn, Stanley I
dc.contributor.authorSigurdsson, Engilbert
dc.contributor.authorSinnamon, Grant B C
dc.contributor.authorSmit, Johannes H
dc.contributor.authorSmith, Daniel J
dc.contributor.authorStefansson, Hreinn
dc.contributor.authorSteinberg, Stacy
dc.contributor.authorStockmeier, Craig A
dc.contributor.authorStreit, Fabian
dc.contributor.authorStrohmaier, Jana
dc.contributor.authorTansey, Katherine E
dc.contributor.authorTeismann, Henning
dc.contributor.authorTeumer, Alexander
dc.contributor.authorThompson, Wesley
dc.contributor.authorThomson, Pippa A
dc.contributor.authorThorgeirsson, Thorgeir E
dc.contributor.authorTian, Chao
dc.contributor.authorTraylor, Matthew
dc.contributor.authorTreutlein, Jens
dc.contributor.authorTrubetskoy, Vassily
dc.contributor.authorUitterlinden, André G
dc.contributor.authorUmbricht, Daniel
dc.contributor.authorVan der Auwera, Sandra
dc.contributor.authorvan Hemert, Albert M
dc.contributor.authorViktorin, Alexander
dc.contributor.authorVisscher, Peter M
dc.contributor.authorWang, Yunpeng
dc.contributor.authorWebb, Bradley T
dc.contributor.authorWeinsheimer, Shantel Marie
dc.contributor.authorWellmann, Jürgen
dc.contributor.authorWillemsen, Gonneke
dc.contributor.authorWitt, Stephanie H
dc.contributor.authorWu, Yang
dc.contributor.authorXi, Hualin S
dc.contributor.authorYang, Jian
dc.contributor.authorZhang, Futao
dc.contributor.authorArolt, Volker
dc.contributor.authorBaune, Bernhard T
dc.contributor.authorBerger, Klaus
dc.contributor.authorBoomsma, Dorret I
dc.contributor.authorCichon, Sven
dc.contributor.authorDannlowski, Udo
dc.contributor.authorde Geus, E C J
dc.contributor.authorDePaulo, J Raymond
dc.contributor.authorDomenici, Enrico
dc.contributor.authorDomschke, Katharina
dc.contributor.authorEsko, Tõnu
dc.contributor.authorGrabe, Hans J
dc.contributor.authorHamilton, Steven P
dc.contributor.authorHayward, Caroline
dc.contributor.authorHeath, Andrew C
dc.contributor.authorHinds, David A
dc.contributor.authorKendler, Kenneth S
dc.contributor.authorKloiber, Stefan
dc.contributor.authorLewis, Glyn
dc.contributor.authorLi, Qingqin S
dc.contributor.authorLucae, Susanne
dc.contributor.authorMadden, Pamela F A
dc.contributor.authorMagnusson, Patrik K
dc.contributor.authorMartin, Nicholas G
dc.contributor.authorMcIntosh, Andrew M
dc.contributor.authorMetspalu, Andres
dc.contributor.authorMors, Ole
dc.contributor.authorMortensen, Preben Bo
dc.contributor.authorMüller-Myhsok, Bertram
dc.contributor.authorNordentoft, Merete
dc.contributor.authorNöthen, Markus M
dc.contributor.authorO'Donovan, Michael C
dc.contributor.authorPaciga, Sara A
dc.contributor.authorPedersen, Nancy L
dc.contributor.authorPenninx, Brenda W J H
dc.contributor.authorPerlis, Roy H
dc.contributor.authorPorteous, David J
dc.contributor.authorPotash, James B
dc.contributor.authorPreisig, Martin
dc.contributor.authorRietschel, Marcella
dc.contributor.authorSchaefer, Catherine
dc.contributor.authorSchulze, Thomas G
dc.contributor.authorSmoller, Jordan W
dc.contributor.authorStefansson, Kari
dc.contributor.authorTiemeier, Henning
dc.contributor.authorUher, Rudolf
dc.contributor.authorVölzke, Henry
dc.contributor.authorWeissman, Myrna M
dc.contributor.authorWerge, Thomas
dc.contributor.authorWinslow, Ashley R
dc.contributor.authorLewis, Cathryn M
dc.contributor.authorLevinson, Douglas F
dc.contributor.authorBreen, Gerome
dc.contributor.authorBørglum, Anders D
dc.contributor.authorSullivan, Patrick F
dc.date.accessioned2023-02-15T19:48:57Z
dc.date.available2023-02-15T19:48:57Z
dc.date.issued2018-04-26
dc.identifier.citationWray NR, Ripke S, Mattheisen M, Trzaskowski M, Byrne EM, Abdellaoui A, Adams MJ, Agerbo E, Air TM, Andlauer TMF, Bacanu SA, Bækvad-Hansen M, Beekman AFT, Bigdeli TB, Binder EB, Blackwood DRH, Bryois J, Buttenschøn HN, Bybjerg-Grauholm J, Cai N, Castelao E, Christensen JH, Clarke TK, Coleman JIR, Colodro-Conde L, Couvy-Duchesne B, Craddock N, Crawford GE, Crowley CA, Dashti HS, Davies G, Deary IJ, Degenhardt F, Derks EM, Direk N, Dolan CV, Dunn EC, Eley TC, Eriksson N, Escott-Price V, Kiadeh FHF, Finucane HK, Forstner AJ, Frank J, Gaspar HA, Gill M, Giusti-Rodríguez P, Goes FS, Gordon SD, Grove J, Hall LS, Hannon E, Hansen CS, Hansen TF, Herms S, Hickie IB, Hoffmann P, Homuth G, Horn C, Hottenga JJ, Hougaard DM, Hu M, Hyde CL, Ising M, Jansen R, Jin F, Jorgenson E, Knowles JA, Kohane IS, Kraft J, Kretzschmar WW, Krogh J, Kutalik Z, Lane JM, Li Y, Li Y, Lind PA, Liu X, Lu L, MacIntyre DJ, MacKinnon DF, Maier RM, Maier W, Marchini J, Mbarek H, McGrath P, McGuffin P, Medland SE, Mehta D, Middeldorp CM, Mihailov E, Milaneschi Y, Milani L, Mill J, Mondimore FM, Montgomery GW, Mostafavi S, Mullins N, Nauck M, Ng B, Nivard MG, Nyholt DR, O'Reilly PF, Oskarsson H, Owen MJ, Painter JN, Pedersen CB, Pedersen MG, Peterson RE, Pettersson E, Peyrot WJ, Pistis G, Posthuma D, Purcell SM, Quiroz JA, Qvist P, Rice JP, Riley BP, Rivera M, Saeed Mirza S, Saxena R, Schoevers R, Schulte EC, Shen L, Shi J, Shyn SI, Sigurdsson E, Sinnamon GBC, Smit JH, Smith DJ, Stefansson H, Steinberg S, Stockmeier CA, Streit F, Strohmaier J, Tansey KE, Teismann H, Teumer A, Thompson W, Thomson PA, Thorgeirsson TE, Tian C, Traylor M, Treutlein J, Trubetskoy V, Uitterlinden AG, Umbricht D, Van der Auwera S, van Hemert AM, Viktorin A, Visscher PM, Wang Y, Webb BT, Weinsheimer SM, Wellmann J, Willemsen G, Witt SH, Wu Y, Xi HS, Yang J, Zhang F; eQTLGen; 23andMe; Arolt V, Baune BT, Berger K, Boomsma DI, Cichon S, Dannlowski U, de Geus ECJ, DePaulo JR, Domenici E, Domschke K, Esko T, Grabe HJ, Hamilton SP, Hayward C, Heath AC, Hinds DA, Kendler KS, Kloiber S, Lewis G, Li QS, Lucae S, Madden PFA, Magnusson PK, Martin NG, McIntosh AM, Metspalu A, Mors O, Mortensen PB, Müller-Myhsok B, Nordentoft M, Nöthen MM, O'Donovan MC, Paciga SA, Pedersen NL, Penninx BWJH, Perlis RH, Porteous DJ, Potash JB, Preisig M, Rietschel M, Schaefer C, Schulze TG, Smoller JW, Stefansson K, Tiemeier H, Uher R, Völzke H, Weissman MM, Werge T, Winslow AR, Lewis CM, Levinson DF, Breen G, Børglum AD, Sullivan PF; Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium. Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression. Nat Genet. 2018 May;50(5):668-681. doi: 10.1038/s41588-018-0090-3. Epub 2018 Apr 26. PMID: 29700475; PMCID: PMC5934326.en_US
dc.identifier.eissn1546-1718
dc.identifier.doi10.1038/s41588-018-0090-3
dc.identifier.pmid29700475
dc.identifier.urihttp://hdl.handle.net/20.500.12648/8374
dc.description.abstractMajor depressive disorder (MDD) is a common illness accompanied by considerable morbidity, mortality, costs, and heightened risk of suicide. We conducted a genome-wide association meta-analysis based in 135,458 cases and 344,901 controls and identified 44 independent and significant loci. The genetic findings were associated with clinical features of major depression and implicated brain regions exhibiting anatomical differences in cases. Targets of antidepressant medications and genes involved in gene splicing were enriched for smaller association signal. We found important relationships of genetic risk for major depression with educational attainment, body mass, and schizophrenia: lower educational attainment and higher body mass were putatively causal, whereas major depression and schizophrenia reflected a partly shared biological etiology. All humans carry lesser or greater numbers of genetic risk factors for major depression. These findings help refine the basis of major depression and imply that a continuous measure of risk underlies the clinical phenotype.
dc.language.isoenen_US
dc.relation.urlhttps://www.nature.com/articles/s41588-018-0090-3en_US
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.titleGenome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression.en_US
dc.typeArticle/Reviewen_US
dc.source.journaltitleNature geneticsen_US
dc.source.volume50
dc.source.issue5
dc.source.beginpage668
dc.source.endpage681
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited Kingdom
dc.source.countryUnited Kingdom
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited Kingdom
dc.source.countryUnited States
dc.source.countryUnited Kingdom
dc.source.countryUnited Kingdom
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited Kingdom
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited Kingdom
dc.source.countryUnited Kingdom
dc.source.countryUnited States
dc.description.versionAMen_US
refterms.dateFOA2023-02-15T19:48:57Z
html.description.abstractMajor depressive disorder (MDD) is a common illness accompanied by considerable morbidity, mortality, costs, and heightened risk of suicide. We conducted a genome-wide association meta-analysis based in 135,458 cases and 344,901 controls and identified 44 independent and significant loci. The genetic findings were associated with clinical features of major depression and implicated brain regions exhibiting anatomical differences in cases. Targets of antidepressant medications and genes involved in gene splicing were enriched for smaller association signal. We found important relationships of genetic risk for major depression with educational attainment, body mass, and schizophrenia: lower educational attainment and higher body mass were putatively causal, whereas major depression and schizophrenia reflected a partly shared biological etiology. All humans carry lesser or greater numbers of genetic risk factors for major depression. These findings help refine the basis of major depression and imply that a continuous measure of risk underlies the clinical phenotype.
dc.description.institutionSUNY Downstateen_US
dc.description.departmentPsychiatry and Behavioral Sciencesen_US
dc.description.departmentInstitute for Genomics in Healthen_US
dc.description.degreelevelN/Aen_US
dc.identifier.journalNature genetics


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