Replication of the Interaction of PRKG1 and Trauma Exposure on Alcohol Misuse in an Independent African American Sample.
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AuthorHawn, Sage E
Sheerin, Christina M
Webb, Bradley T
Peterson, Roseann E
Do, Elizabeth K
Kendler, Kenneth S
Amstadter, Ananda B
Journal titleJournal of traumatic stress
Publication Begin page927
Publication End page932
MetadataShow full item record
AbstractIn the present study, we sought to replicate recent findings of Polimanti et al. (2017), who conducted a genome-wide gene-by-environment interaction study (GEWIS) and identified a gene-by-trauma interaction that predicts alcohol misuse among African Americans. Consistent with the findings published by Polimanti and colleagues, results of the current study demonstrated an interaction effect, b = 0.41, of trauma exposure and rs1729578 in the intron of PRKG1 on alcohol misuse in a subsample of ancestral African Americans. The minor allele (rs1729578*C) was positively associated with increased alcohol use disorder symptoms in trauma-exposed subjects and negatively associated in non-trauma-exposed subjects. This effect, however, was only significant for one out of three alcohol outcome measures we investigated, suggesting the interaction may be most salient when predicting higher severity of alcohol misuse. Additionally, the effect did not remain significant after we accounted for testing the effect on three different outcome variables. Also in line with the original study, the gene-by-environment effect was not demonstrated among the ancestral European subsample. The findings suggest this gene variant may increase an individual's susceptibility to environmental influences, both adverse and supportive.
CitationHawn SE, Sheerin CM, Webb BT, Peterson RE, Do EK, Dick D, Kendler KS, Bacanu SA, Amstadter AB. Replication of the Interaction of PRKG1 and Trauma Exposure on Alcohol Misuse in an Independent African American Sample. J Trauma Stress. 2018 Dec;31(6):927-932. doi: 10.1002/jts.22339. Epub 2018 Oct 30. PMID: 30376604; PMCID: PMC6295354.
The following license files are associated with this item:
- Creative Commons
Except where otherwise noted, this item's license is described as © 2018 International Society for Traumatic Stress Studies.
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