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dc.contributor.authorMartin, Joanna
dc.contributor.authorKhramtsova, Ekaterina A
dc.contributor.authorGoleva, Slavina B
dc.contributor.authorBlokland, Gabriëlla A M
dc.contributor.authorTraglia, Michela
dc.contributor.authorWalters, Raymond K
dc.contributor.authorHübel, Christopher
dc.contributor.authorColeman, Jonathan R I
dc.contributor.authorBreen, Gerome
dc.contributor.authorBørglum, Anders D
dc.contributor.authorDemontis, Ditte
dc.contributor.authorGrove, Jakob
dc.contributor.authorWerge, Thomas
dc.contributor.authorBralten, Janita
dc.contributor.authorBulik, Cynthia M
dc.contributor.authorLee, Phil H
dc.contributor.authorMathews, Carol A
dc.contributor.authorPeterson, Roseann E
dc.contributor.authorWinham, Stacey J
dc.contributor.authorWray, Naomi
dc.contributor.authorEdenberg, Howard J
dc.contributor.authorGuo, Wei
dc.contributor.authorYao, Yin
dc.contributor.authorNeale, Benjamin M
dc.contributor.authorFaraone, Stephen V
dc.contributor.authorPetryshen, Tracey L
dc.contributor.authorWeiss, Lauren A
dc.contributor.authorDuncan, Laramie E
dc.contributor.authorGoldstein, Jill M
dc.contributor.authorSmoller, Jordan W
dc.contributor.authorStranger, Barbara E
dc.contributor.authorDavis, Lea K
dc.date.accessioned2023-02-13T19:40:33Z
dc.date.available2023-02-13T19:40:33Z
dc.date.issued2021-01-09
dc.identifier.citationMartin J, Khramtsova EA, Goleva SB, Blokland GAM, Traglia M, Walters RK, Hübel C, Coleman JRI, Breen G, Børglum AD, Demontis D, Grove J, Werge T, Bralten J, Bulik CM, Lee PH, Mathews CA, Peterson RE, Winham SJ, Wray N, Edenberg HJ, Guo W, Yao Y, Neale BM, Faraone SV, Petryshen TL, Weiss LA, Duncan LE, Goldstein JM, Smoller JW, Stranger BE, Davis LK; Sex Differences Cross-Disorder Analysis Group of the Psychiatric Genomics Consortium. Examining Sex-Differentiated Genetic Effects Across Neuropsychiatric and Behavioral Traits. Biol Psychiatry. 2021 Jun 15;89(12):1127-1137. doi: 10.1016/j.biopsych.2020.12.024. Epub 2021 Jan 9. PMID: 33648717; PMCID: PMC8163257.en_US
dc.identifier.eissn1873-2402
dc.identifier.doi10.1016/j.biopsych.2020.12.024
dc.identifier.pmid33648717
dc.identifier.urihttp://hdl.handle.net/20.500.12648/8350
dc.description.abstractThe origin of sex differences in prevalence and presentation of neuropsychiatric and behavioral traits is largely unknown. Given established genetic contributions and correlations, we tested for a sex-differentiated genetic architecture within and between traits.
dc.description.abstractUsing European ancestry genome-wide association summary statistics for 20 neuropsychiatric and behavioral traits, we tested for sex differences in single nucleotide polymorphism (SNP)-based heritability and genetic correlation (r < 1). For each trait, we computed per-SNP z scores from sex-stratified regression coefficients and identified genes with sex-differentiated effects using a gene-based approach. We calculated correlation coefficients between z scores to test for shared sex-differentiated effects. Finally, we tested for sex differences in across-trait genetic correlations.
dc.description.abstractWe observed no consistent sex differences in SNP-based heritability. Between-sex, within-trait genetic correlations were high, although <1 for educational attainment and risk-taking behavior. We identified 4 genes with significant sex-differentiated effects across 3 traits. Several trait pairs shared sex-differentiated effects. The top genes with sex-differentiated effects were enriched for multiple gene sets, including neuron- and synapse-related sets. Most between-trait genetic correlation estimates were not significantly different between sexes, with exceptions (educational attainment and risk-taking behavior).
dc.description.abstractSex differences in the common autosomal genetic architecture of neuropsychiatric and behavioral phenotypes are small and polygenic and unlikely to fully account for observed sex-differentiated attributes. Larger sample sizes are needed to identify sex-differentiated effects for most traits. For well-powered studies, we identified genes with sex-differentiated effects that were enriched for neuron-related and other biological functions. This work motivates further investigation of genetic and environmental influences on sex differences.
dc.language.isoenen_US
dc.relation.urlhttps://www.biologicalpsychiatryjournal.com/article/S0006-3223(21)00033-0/fulltexten_US
dc.rightsCopyright © 2021 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectBehavioralen_US
dc.subjectGWASen_US
dc.subjectGenetic correlationen_US
dc.subjectHeritabilityen_US
dc.subjectPsychiatricen_US
dc.subjectSex differencesen_US
dc.titleExamining Sex-Differentiated Genetic Effects Across Neuropsychiatric and Behavioral Traits.en_US
dc.typeArticle/Reviewen_US
dc.source.journaltitleBiological psychiatryen_US
dc.source.volume89
dc.source.issue12
dc.source.beginpage1127
dc.source.endpage1137
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited Kingdom
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.description.versionVoRen_US
refterms.dateFOA2023-02-13T19:40:33Z
html.description.abstractThe origin of sex differences in prevalence and presentation of neuropsychiatric and behavioral traits is largely unknown. Given established genetic contributions and correlations, we tested for a sex-differentiated genetic architecture within and between traits.
html.description.abstractUsing European ancestry genome-wide association summary statistics for 20 neuropsychiatric and behavioral traits, we tested for sex differences in single nucleotide polymorphism (SNP)-based heritability and genetic correlation (r < 1). For each trait, we computed per-SNP z scores from sex-stratified regression coefficients and identified genes with sex-differentiated effects using a gene-based approach. We calculated correlation coefficients between z scores to test for shared sex-differentiated effects. Finally, we tested for sex differences in across-trait genetic correlations.
html.description.abstractWe observed no consistent sex differences in SNP-based heritability. Between-sex, within-trait genetic correlations were high, although <1 for educational attainment and risk-taking behavior. We identified 4 genes with significant sex-differentiated effects across 3 traits. Several trait pairs shared sex-differentiated effects. The top genes with sex-differentiated effects were enriched for multiple gene sets, including neuron- and synapse-related sets. Most between-trait genetic correlation estimates were not significantly different between sexes, with exceptions (educational attainment and risk-taking behavior).
html.description.abstractSex differences in the common autosomal genetic architecture of neuropsychiatric and behavioral phenotypes are small and polygenic and unlikely to fully account for observed sex-differentiated attributes. Larger sample sizes are needed to identify sex-differentiated effects for most traits. For well-powered studies, we identified genes with sex-differentiated effects that were enriched for neuron-related and other biological functions. This work motivates further investigation of genetic and environmental influences on sex differences.
dc.description.institutionSUNY Downstateen_US
dc.description.departmentPsychiatry and Behavioral Sciencesen_US
dc.description.departmentInstitute for Genomics in Healthen_US
dc.description.degreelevelN/Aen_US
dc.identifier.journalBiological psychiatry


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Copyright © 2021 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.
Except where otherwise noted, this item's license is described as Copyright © 2021 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.