Determining the stability of genome-wide factors in BMI between ages 40 to 69 years.
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Author
Gillespie, Nathan AGentry, Amanda Elswick
Kirkpatrick, Robert M
Reynolds, Chandra A
Mathur, Ravi
Kendler, Kenneth S
Maes, Hermine H
Webb, Bradley T
Peterson, Roseann E
Journal title
PLoS geneticsDate Published
2022-08-11Publication Volume
18Publication Issue
8Publication Begin page
e1010303
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Show full item recordAbstract
Genome-wide association studies (GWAS) have successfully identified common variants associated with BMI. However, the stability of aggregate genetic variation influencing BMI from midlife and beyond is unknown. By analysing 165,717 men and 193,073 women from the UKBiobank, we performed BMI GWAS on six independent five-year age intervals between 40 and 72 years. We then applied genomic structural equation modeling to test competing hypotheses regarding the stability of genetic effects for BMI. LDSR genetic correlations between BMI assessed between ages 40 to 73 were all very high and ranged 0.89 to 1.00. Genomic structural equation modeling revealed that molecular genetic variance in BMI at each age interval could not be explained by the accumulation of any age-specific genetic influences or autoregressive processes. Instead, a common set of stable genetic influences appears to underpin genome-wide variation in BMI from middle to early old age in men and women alike.Citation
Gillespie NA, Gentry AE, Kirkpatrick RM, Reynolds CA, Mathur R, Kendler KS, Maes HH, Webb BT, Peterson RE. Determining the stability of genome-wide factors in BMI between ages 40 to 69 years. PLoS Genet. 2022 Aug 11;18(8):e1010303. doi: 10.1371/journal.pgen.1010303. PMID: 35951648; PMCID: PMC9398001.DOI
10.1371/journal.pgen.1010303ae974a485f413a2113503eed53cd6c53
10.1371/journal.pgen.1010303
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