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dc.contributor.authorSales, Paulo M G
dc.contributor.authorSchrage, Ezra
dc.contributor.authorCoico, Richard
dc.contributor.authorPato, Michele
dc.date.accessioned2023-02-09T17:50:44Z
dc.date.available2023-02-09T17:50:44Z
dc.date.issued2022-12-01
dc.identifier.citationSales PMG, Schrage E, Coico R, Pato M. Linking nervous and immune systems in psychiatric illness: A meta-analysis of the kynurenine pathway. Brain Res. 2023 Feb 1;1800:148190. doi: 10.1016/j.brainres.2022.148190. Epub 2022 Dec 1. PMID: 36463958.en_US
dc.identifier.eissn1872-6240
dc.identifier.doi10.1016/j.brainres.2022.148190
dc.identifier.pmid36463958
dc.identifier.urihttp://hdl.handle.net/20.500.12648/8328
dc.description.abstractTryptophan is an essential amino acid absorbed by the gut depending on a homoeostatic microbiome. Up to 95% of unbound tryptophan is converted into tryptophan catabolites (TRYCATs) through the kynurenine system. Recent studies identified conflicting associations between altered levels of TRYCATs and genetic polymorphisms in major depressive disorder (MDD), schizophrenia (SCZ), and bipolar disorder (BD). This meta-analysis aimed to understand how tryptophan catabolic pathways are altered in MDD, SCZ, and BD. When compared to healthy controls, participants with MDD had moderately lower levels of tryptophan associated with a moderate increase of kynurenine/tryptophan ratios and no differences in kynurenine. While significant differences were found in SCZ for any of the TRYCATs, studies on kynurenic acid found opposing directions of effect sizes depending on the sample source. Unique changes in levels of TRYCATs were also observed in BD. Dynamic changes in levels of cytokines and other immune/inflammatory elements modulate the transcription and activity of kynurenine system enzymes, which lastly seems to be impacting glutamatergic neurotransmission via N-methyl-D-aspartate and α-7 nicotine receptors.
dc.language.isoenen_US
dc.relation.urlhttps://www.clinicalkey.com/#!/content/playContent/1-s2.0-S0006899322004140en_US
dc.rightsCopyright © 2022 Elsevier B.V. All rights reserved.
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectKynurenic aciden_US
dc.subjectKynurenineen_US
dc.subjectMood disordersen_US
dc.subjectPsychotic disordersen_US
dc.subjectTryptophanen_US
dc.titleLinking nervous and immune systems in psychiatric illness: A meta-analysis of the kynurenine pathway.en_US
dc.typeArticle/Reviewen_US
dc.source.journaltitleBrain researchen_US
dc.source.volume1800
dc.source.beginpage148190
dc.source.endpage
dc.source.countryNetherlands
dc.description.versionAMen_US
refterms.dateFOA2023-02-09T17:50:45Z
html.description.abstractTryptophan is an essential amino acid absorbed by the gut depending on a homoeostatic microbiome. Up to 95% of unbound tryptophan is converted into tryptophan catabolites (TRYCATs) through the kynurenine system. Recent studies identified conflicting associations between altered levels of TRYCATs and genetic polymorphisms in major depressive disorder (MDD), schizophrenia (SCZ), and bipolar disorder (BD). This meta-analysis aimed to understand how tryptophan catabolic pathways are altered in MDD, SCZ, and BD. When compared to healthy controls, participants with MDD had moderately lower levels of tryptophan associated with a moderate increase of kynurenine/tryptophan ratios and no differences in kynurenine. While significant differences were found in SCZ for any of the TRYCATs, studies on kynurenic acid found opposing directions of effect sizes depending on the sample source. Unique changes in levels of TRYCATs were also observed in BD. Dynamic changes in levels of cytokines and other immune/inflammatory elements modulate the transcription and activity of kynurenine system enzymes, which lastly seems to be impacting glutamatergic neurotransmission via N-methyl-D-aspartate and α-7 nicotine receptors.
dc.description.institutionSUNY Downstateen_US
dc.description.departmentCell Biologyen_US
dc.description.departmentClinical & Translational Science Centeren_US
dc.description.degreelevelN/Aen_US
dc.identifier.journalBrain research


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Copyright © 2022 Elsevier B.V. All rights reserved.
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