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dc.contributor.authorLegge, Alexandra
dc.contributor.authorKirkland, Susan
dc.contributor.authorRockwood, Kenneth
dc.contributor.authorAndreou, Pantelis
dc.contributor.authorBae, Sang-Cheol
dc.contributor.authorGordon, Caroline
dc.contributor.authorRomero-Diaz, Juanita
dc.contributor.authorSanchez-Guerrero, Jorge
dc.contributor.authorWallace, Daniel J
dc.contributor.authorBernatsky, Sasha
dc.contributor.authorClarke, Ann E
dc.contributor.authorMerrill, Joan T
dc.contributor.authorGinzler, Ellen M
dc.contributor.authorFortin, Paul
dc.contributor.authorGladman, Dafna D
dc.contributor.authorUrowitz, Murray B
dc.contributor.authorBruce, Ian N
dc.contributor.authorIsenberg, David A
dc.contributor.authorRahman, Anisur
dc.contributor.authorAlarcón, Graciela S
dc.contributor.authorPetri, Michelle
dc.contributor.authorKhamashta, Munther A
dc.contributor.authorDooley, M A
dc.contributor.authorRamsey-Goldman, Rosalind
dc.contributor.authorManzi, Susan
dc.contributor.authorSteinsson, Kristjan
dc.contributor.authorZoma, Asad A
dc.contributor.authorAranow, Cynthia
dc.contributor.authorMackay, Meggan
dc.contributor.authorRuiz-Irastorza, Guillermo
dc.contributor.authorLim, S Sam
dc.contributor.authorInanc, Murat
dc.contributor.authorvan Vollenhoven, Ronald F
dc.contributor.authorJonsen, Andreas
dc.contributor.authorNived, Ola
dc.contributor.authorRamos-Casals, Manuel
dc.contributor.authorKamen, Diane L
dc.contributor.authorKalunian, Kenneth C
dc.contributor.authorJacobsen, Soren
dc.contributor.authorPeschken, Christine A
dc.contributor.authorAskanase, Anca
dc.contributor.authorHanly, John G
dc.date.accessioned2023-02-08T19:00:27Z
dc.date.available2023-02-08T19:00:27Z
dc.date.issued2019-05-29
dc.identifier.citationLegge A, Kirkland S, Rockwood K, Andreou P, Bae SC, Gordon C, Romero-Diaz J, Sanchez-Guerrero J, Wallace DJ, Bernatsky S, Clarke AE, Merrill JT, Ginzler EM, Fortin P, Gladman DD, Urowitz MB, Bruce IN, Isenberg DA, Rahman A, Alarcón GS, Petri M, Khamashta MA, Dooley MA, Ramsey-Goldman R, Manzi S, Steinsson K, Zoma AA, Aranow C, Mackay M, Ruiz-Irastorza G, Lim SS, Inanc M, van Vollenhoven RF, Jonsen A, Nived O, Ramos-Casals M, Kamen DL, Kalunian KC, Jacobsen S, Peschken CA, Askanase A, Hanly JG. Evaluating the Properties of a Frailty Index and Its Association With Mortality Risk Among Patients With Systemic Lupus Erythematosus. Arthritis Rheumatol. 2019 Aug;71(8):1297-1307. doi: 10.1002/art.40859. Epub 2019 May 29. PMID: 30771242; PMCID: PMC6663648.en_US
dc.identifier.eissn2326-5205
dc.identifier.doi10.1002/art.40859
dc.identifier.pmid30771242
dc.identifier.urihttp://hdl.handle.net/20.500.12648/8302
dc.description.abstractTo evaluate the properties of a frailty index (FI), constructed using data from the Systemic Lupus International Collaborating Clinics (SLICC) inception cohort, as a novel health measure in systemic lupus erythematosus (SLE).
dc.description.abstractFor this secondary analysis, the baseline visit was defined as the first study visit at which both organ damage (SLICC/American College of Rheumatology Damage Index [SDI]) and health-related quality of life (Short-Form 36 [SF-36] scores) were assessed. The SLICC-FI was constructed using baseline data. The SLICC-FI comprises 48 health deficits, including items related to organ damage, disease activity, comorbidities, and functional status. Content, construct, and criterion validity of the SLICC-FI were assessed. Multivariable Cox regression was used to estimate the association between baseline SLICC-FI values and mortality risk, adjusting for demographic and clinical factors.
dc.description.abstractIn the baseline data set of 1,683 patients with SLE, 89% were female, the mean ± SD age was 35.7 ± 13.4 years, and the mean ± SD disease duration was 18.8 ± 15.7 months. At baseline, the mean ± SD SLICC-FI score was 0.17 ± 0.08 (range 0-0.51). Baseline SLICC-FI values exhibited the expected measurement properties and were weakly correlated with baseline SDI scores (r = 0.26, P < 0.0001). Higher baseline SLICC-FI values (per 0.05 increment) were associated with increased mortality risk (hazard ratio 1.59, 95% confidence interval 1.35-1.87), after adjusting for age, sex, steroid use, ethnicity/region, and baseline SDI scores.
dc.description.abstractThe SLICC-FI demonstrates internal validity as a health measure in SLE and might be used to predict future mortality risk. The SLICC-FI is potentially valuable for quantifying vulnerability among patients with SLE, and adds to existing prognostic scores.
dc.language.isoenen_US
dc.relation.urlhttps://onlinelibrary.wiley.com/doi/epdf/10.1002/art.40859en_US
dc.rights© 2019, American College of Rheumatology.
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.titleEvaluating the Properties of a Frailty Index and Its Association With Mortality Risk Among Patients With Systemic Lupus Erythematosus.en_US
dc.typeArticle/Reviewen_US
dc.source.journaltitleArthritis & rheumatology (Hoboken, N.J.)en_US
dc.source.volume71
dc.source.issue8
dc.source.beginpage1297
dc.source.endpage1307
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryCanada
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryInternational
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited Kingdom
dc.source.countryUnited States
dc.description.versionAMen_US
refterms.dateFOA2023-02-08T19:00:28Z
html.description.abstractTo evaluate the properties of a frailty index (FI), constructed using data from the Systemic Lupus International Collaborating Clinics (SLICC) inception cohort, as a novel health measure in systemic lupus erythematosus (SLE).
html.description.abstractFor this secondary analysis, the baseline visit was defined as the first study visit at which both organ damage (SLICC/American College of Rheumatology Damage Index [SDI]) and health-related quality of life (Short-Form 36 [SF-36] scores) were assessed. The SLICC-FI was constructed using baseline data. The SLICC-FI comprises 48 health deficits, including items related to organ damage, disease activity, comorbidities, and functional status. Content, construct, and criterion validity of the SLICC-FI were assessed. Multivariable Cox regression was used to estimate the association between baseline SLICC-FI values and mortality risk, adjusting for demographic and clinical factors.
html.description.abstractIn the baseline data set of 1,683 patients with SLE, 89% were female, the mean ± SD age was 35.7 ± 13.4 years, and the mean ± SD disease duration was 18.8 ± 15.7 months. At baseline, the mean ± SD SLICC-FI score was 0.17 ± 0.08 (range 0-0.51). Baseline SLICC-FI values exhibited the expected measurement properties and were weakly correlated with baseline SDI scores (r = 0.26, P < 0.0001). Higher baseline SLICC-FI values (per 0.05 increment) were associated with increased mortality risk (hazard ratio 1.59, 95% confidence interval 1.35-1.87), after adjusting for age, sex, steroid use, ethnicity/region, and baseline SDI scores.
html.description.abstractThe SLICC-FI demonstrates internal validity as a health measure in SLE and might be used to predict future mortality risk. The SLICC-FI is potentially valuable for quantifying vulnerability among patients with SLE, and adds to existing prognostic scores.
dc.description.institutionSUNY Downstateen_US
dc.description.departmentRheumatologyen_US
dc.description.degreelevelN/Aen_US
dc.identifier.journalArthritis & rheumatology (Hoboken, N.J.)


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© 2019, American College of Rheumatology.
Except where otherwise noted, this item's license is described as © 2019, American College of Rheumatology.