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dc.contributor.authorFerreira, Isabel
dc.contributor.authorCroca, Sara
dc.contributor.authorRaimondo, Maria Gabriella
dc.contributor.authorMatharu, Manjit
dc.contributor.authorMiller, Sarah
dc.contributor.authorGiles, Ian
dc.contributor.authorIsenberg, David
dc.contributor.authorIoannou, Yiannis
dc.contributor.authorHanly, John G
dc.contributor.authorUrowitz, Murray B
dc.contributor.authorAnderson, Nicole
dc.contributor.authorAranow, Cynthia
dc.contributor.authorAskanase, Anca
dc.contributor.authorBae, Sang-Cheol
dc.contributor.authorBernatsky, Sasha
dc.contributor.authorBruce, Ian N
dc.contributor.authorBuyon, Jill
dc.contributor.authorClarke, Ann E
dc.contributor.authorDooley, Mary Anne
dc.contributor.authorFortin, Paul
dc.contributor.authorGinzler, Ellen
dc.contributor.authorGladman, Dafna
dc.contributor.authorGordon, Caroline
dc.contributor.authorInanc, Murat
dc.contributor.authorJacobsen, Søren
dc.contributor.authorKalunian, Kenneth
dc.contributor.authorKamen, Diane
dc.contributor.authorKhamashta, Munther
dc.contributor.authorLim, Sam
dc.contributor.authorManzi, Susan
dc.contributor.authorMerrill, Joan
dc.contributor.authorNived, Ola
dc.contributor.authorPeschken, Christine
dc.contributor.authorPetri, Michelle
dc.contributor.authorRamsey-Goldman, Rosalind
dc.contributor.authorRuiz-Irastorza, Guillermo
dc.contributor.authorSanchez-Guerrero, Jorge
dc.contributor.authorSteinson, Kristjan
dc.contributor.authorSturfelt, Gunnar K
dc.contributor.authorvan Vollenhoven, Ronald
dc.contributor.authorWallace, Daniel J
dc.contributor.authorZoma, Asad
dc.contributor.authorRahman, Anisur
dc.date.accessioned2023-02-07T17:34:47Z
dc.date.available2023-02-07T17:34:47Z
dc.date.issued2017-12-22
dc.identifier.citationFerreira I, Croca S, Raimondo MG, Matharu M, Miller S, Giles I, Isenberg D, Ioannou Y, Hanly JG, Urowitz MB, Anderson N, Aranow C, Askanase A, Bae SC, Bernatsky S, Bruce IN, Buyon J, Clarke AE, Dooley MA, Fortin P, Ginzler E, Gladman D, Gordon C, Inanc M, Jacobsen S, Kalunian K, Kamen D, Khamashta M, Lim S, Manzi S, Merrill J, Nived O, Peschken C, Petri M, Ramsey-Goldman R, Ruiz-Irastorza G, Sanchez-Guerrero J, Steinson K, Sturfelt GK, van Vollenhoven R, Wallace DJ, Zoma A, Rahman A. Nitrated nucleosome levels and neuropsychiatric events in systemic lupus erythematosus; a multi-center retrospective case-control study. Arthritis Res Ther. 2017 Dec 22;19(1):287. doi: 10.1186/s13075-017-1495-6. PMID: 29273092; PMCID: PMC5741886.en_US
dc.identifier.eissn1478-6362
dc.identifier.doi10.1186/s13075-017-1495-6
dc.identifier.pmid29273092
dc.identifier.urihttp://hdl.handle.net/20.500.12648/8290
dc.description.abstractIn patients with systemic lupus erythematosus (SLE) there is no serological test that will reliably distinguish neuropsychiatric (NP) events due to active SLE from those due to other causes. Previously we showed that serum levels of nitrated nucleosomes (NN) were elevated in a small number of patients with NPSLE. Here we measured serum NN in samples from a larger population of patients with SLE and NP events to see whether elevated serum NN could be a marker for NPSLE.
dc.description.abstractWe obtained serum samples from patients in the Systemic Lupus International Collaborative Clinics (SLICC) inception cohort. This included 216 patients with NP events and two matched controls with SLE but no NP events for each of these patients. For the NP patients we tested samples taken before, during and after the NP event.
dc.description.abstractTwenty-six patients had events attributed to SLE according to the most stringent SLICC attribution rule. In these patients there was no association between onset of event and elevated serum NN. In 190 patients in whom events were not attributed to SLE by the SLICC rules, median serum NN was elevated at the onset of event (P = 0.006). The predominant clinical features in this group of 190 patients were headache, mood disorders and anxiety.
dc.description.abstractSerum NN levels rise at the time of an NP event in a proportion of patients with SLE. Further studies are needed to determine the value of serum NN as a biomarker for NPSLE.
dc.language.isoenen_US
dc.relation.urlhttps://arthritis-research.biomedcentral.com/articles/10.1186/s13075-017-1495-6en_US
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectNeuropsychiatricen_US
dc.subjectNitrationen_US
dc.subjectNucleosomesen_US
dc.subjectSystemic lupus erythematosusen_US
dc.titleNitrated nucleosome levels and neuropsychiatric events in systemic lupus erythematosus; a multi-center retrospective case-control study.en_US
dc.typeArticle/Reviewen_US
dc.source.journaltitleArthritis research & therapyen_US
dc.source.volume19
dc.source.issue1
dc.source.beginpage287
dc.source.endpage
dc.source.countryUnited States
dc.source.countryUnited Kingdom
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited Kingdom
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited Kingdom
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryCanada
dc.source.countryUnited Kingdom
dc.source.countryEngland
dc.description.versionVoRen_US
refterms.dateFOA2023-02-07T17:34:48Z
html.description.abstractIn patients with systemic lupus erythematosus (SLE) there is no serological test that will reliably distinguish neuropsychiatric (NP) events due to active SLE from those due to other causes. Previously we showed that serum levels of nitrated nucleosomes (NN) were elevated in a small number of patients with NPSLE. Here we measured serum NN in samples from a larger population of patients with SLE and NP events to see whether elevated serum NN could be a marker for NPSLE.
html.description.abstractWe obtained serum samples from patients in the Systemic Lupus International Collaborative Clinics (SLICC) inception cohort. This included 216 patients with NP events and two matched controls with SLE but no NP events for each of these patients. For the NP patients we tested samples taken before, during and after the NP event.
html.description.abstractTwenty-six patients had events attributed to SLE according to the most stringent SLICC attribution rule. In these patients there was no association between onset of event and elevated serum NN. In 190 patients in whom events were not attributed to SLE by the SLICC rules, median serum NN was elevated at the onset of event (P = 0.006). The predominant clinical features in this group of 190 patients were headache, mood disorders and anxiety.
html.description.abstractSerum NN levels rise at the time of an NP event in a proportion of patients with SLE. Further studies are needed to determine the value of serum NN as a biomarker for NPSLE.
dc.description.institutionSUNY Downstateen_US
dc.description.departmentRheumatologyen_US
dc.description.degreelevelN/Aen_US
dc.identifier.journalArthritis research & therapy


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