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dc.contributor.authorUrowitz, M B
dc.contributor.authorGladman, D D
dc.contributor.authorAnderson, N M
dc.contributor.authorSu, J
dc.contributor.authorRomero-Diaz, J
dc.contributor.authorBae, S C
dc.contributor.authorFortin, P R
dc.contributor.authorSanchez-Guerrero, J
dc.contributor.authorClarke, A
dc.contributor.authorBernatsky, S
dc.contributor.authorGordon, C
dc.contributor.authorHanly, J G
dc.contributor.authorWallace, D J
dc.contributor.authorIsenberg, D
dc.contributor.authorRahman, A
dc.contributor.authorMerrill, J
dc.contributor.authorGinzler, E
dc.contributor.authorAlarcón, G S
dc.contributor.authorFessler, B F
dc.contributor.authorPetri, M
dc.contributor.authorBruce, I N
dc.contributor.authorKhamashta, M
dc.contributor.authorAranow, C
dc.contributor.authorDooley, M
dc.contributor.authorManzi, S
dc.contributor.authorRamsey-Goldman, R
dc.contributor.authorSturfelt, G
dc.contributor.authorNived, O
dc.contributor.authorSteinsson, K
dc.contributor.authorZoma, A
dc.contributor.authorRuiz-Irastorza, G
dc.contributor.authorLim, S
dc.contributor.authorKalunian, K C
dc.contributor.authorỈnanç, M
dc.contributor.authorvan Vollenhoven, R
dc.contributor.authorRamos-Casals, M
dc.contributor.authorKamen, D L
dc.contributor.authorJacobsen, S
dc.contributor.authorPeschken, C
dc.contributor.authorAskanase, A
dc.contributor.authorStoll, T
dc.date.accessioned2023-02-07T17:24:47Z
dc.date.available2023-02-07T17:24:47Z
dc.date.issued2016-04-12
dc.identifier.citationUrowitz MB, Gladman DD, Anderson NM, Su J, Romero-Diaz J, Bae SC, Fortin PR, Sanchez-Guerrero J, Clarke A, Bernatsky S, Gordon C, Hanly JG, Wallace DJ, Isenberg D, Rahman A, Merrill J, Ginzler E, Alarcón GS, Fessler BF, Petri M, Bruce IN, Khamashta M, Aranow C, Dooley M, Manzi S, Ramsey-Goldman R, Sturfelt G, Nived O, Steinsson K, Zoma A, Ruiz-Irastorza G, Lim S, Kalunian KC, Ỉnanç M, van Vollenhoven R, Ramos-Casals M, Kamen DL, Jacobsen S, Peschken C, Askanase A, Stoll T. Cardiovascular events prior to or early after diagnosis of systemic lupus erythematosus in the systemic lupus international collaborating clinics cohort. Lupus Sci Med. 2016 Apr 12;3(1):e000143. doi: 10.1136/lupus-2015-000143. Erratum in: Lupus Sci Med. 2016;3(1):e000143corr1. PMID: 27099765; PMCID: PMC4836282.en_US
dc.identifier.issn2053-8790
dc.identifier.doi10.1136/lupus-2015-000143
dc.identifier.pmid27099765
dc.identifier.urihttp://hdl.handle.net/20.500.12648/8288
dc.description.abstractTo describe the frequency of myocardial infarction (MI) prior to the diagnosis of systemic lupus erythematosus (SLE) and within the first 2 years of follow-up.
dc.description.abstractThe systemic lupus international collaborating clinics (SLICC) atherosclerosis inception cohort enters patients within 15 months of SLE diagnosis. MIs were reported and attributed on a specialised vascular event form. MIs were confirmed by one or more of the following: abnormal ECG, typical or atypical symptoms with ECG abnormalities and elevated enzymes (≥2 times upper limit of normal), or abnormal stress test, echocardiogram, nuclear scan or angiogram. Descriptive statistics were used.
dc.description.abstract31 of 1848 patients who entered the cohort had an MI. Of those, 23 patients had an MI prior to SLE diagnosis or within the first 2 years of disease. Of the 23 patients studied, 60.9% were female, 78.3% were Caucasian, 8.7% black, 8.7% Hispanic and 4.3% other. The mean age at SLE diagnosis was 52.5±15.0 years. Of the 23 MIs that occurred, 16 MIs occurred at a mean of 6.1±7.0 years prior to diagnosis and 7 occurred within the first 2 years of follow-up. Risk factors associated with early MI in univariate analysis are male sex, Caucasian, older age at diagnosis, hypertension, hypercholesterolaemia, family history of MI and smoking. In multivariate analysis only age (OR=1.06 95% CI 1.03 to 1.09), hypertension (OR=5.01, 95% CI 1.38 to 18.23), hypercholesterolaemia (OR=4.43, 95% CI 1.51 to 12.99) and smoking (OR=7.50, 95% CI 2.38 to 23.57) remained significant risk factors.
dc.description.abstractIn some patients with lupus, MI may develop even before the diagnosis of SLE or shortly thereafter, suggesting that there may be a link between autoimmune inflammation and atherosclerosis.
dc.language.isoenen_US
dc.relation.urlhttps://lupus.bmj.com/content/3/1/e000143.longen_US
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectCardiovascular Diseaseen_US
dc.subjectInflammationen_US
dc.subjectSystemic Lupus Erythematosusen_US
dc.titleCardiovascular events prior to or early after diagnosis of systemic lupus erythematosus in the systemic lupus international collaborating clinics cohort.en_US
dc.typeArticle/Reviewen_US
dc.source.journaltitleLupus science & medicineen_US
dc.source.volume3
dc.source.issue1
dc.source.beginpagee000143
dc.source.endpage
dc.source.countryEngland
dc.description.versionVoRen_US
refterms.dateFOA2023-02-07T17:24:47Z
html.description.abstractTo describe the frequency of myocardial infarction (MI) prior to the diagnosis of systemic lupus erythematosus (SLE) and within the first 2 years of follow-up.
html.description.abstractThe systemic lupus international collaborating clinics (SLICC) atherosclerosis inception cohort enters patients within 15 months of SLE diagnosis. MIs were reported and attributed on a specialised vascular event form. MIs were confirmed by one or more of the following: abnormal ECG, typical or atypical symptoms with ECG abnormalities and elevated enzymes (≥2 times upper limit of normal), or abnormal stress test, echocardiogram, nuclear scan or angiogram. Descriptive statistics were used.
html.description.abstract31 of 1848 patients who entered the cohort had an MI. Of those, 23 patients had an MI prior to SLE diagnosis or within the first 2 years of disease. Of the 23 patients studied, 60.9% were female, 78.3% were Caucasian, 8.7% black, 8.7% Hispanic and 4.3% other. The mean age at SLE diagnosis was 52.5±15.0 years. Of the 23 MIs that occurred, 16 MIs occurred at a mean of 6.1±7.0 years prior to diagnosis and 7 occurred within the first 2 years of follow-up. Risk factors associated with early MI in univariate analysis are male sex, Caucasian, older age at diagnosis, hypertension, hypercholesterolaemia, family history of MI and smoking. In multivariate analysis only age (OR=1.06 95% CI 1.03 to 1.09), hypertension (OR=5.01, 95% CI 1.38 to 18.23), hypercholesterolaemia (OR=4.43, 95% CI 1.51 to 12.99) and smoking (OR=7.50, 95% CI 2.38 to 23.57) remained significant risk factors.
html.description.abstractIn some patients with lupus, MI may develop even before the diagnosis of SLE or shortly thereafter, suggesting that there may be a link between autoimmune inflammation and atherosclerosis.
dc.description.institutionSUNY Downstateen_US
dc.description.departmentRheumatologyen_US
dc.description.degreelevelN/Aen_US
dc.identifier.journalLupus science & medicine


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