Show simple item record

dc.contributor.authorHanly, John G
dc.contributor.authorO'Keeffe, Aidan G
dc.contributor.authorSu, Li
dc.contributor.authorUrowitz, Murray B
dc.contributor.authorRomero-Diaz, Juanita
dc.contributor.authorGordon, Caroline
dc.contributor.authorBae, Sang-Cheol
dc.contributor.authorBernatsky, Sasha
dc.contributor.authorClarke, Ann E
dc.contributor.authorWallace, Daniel J
dc.contributor.authorMerrill, Joan T
dc.contributor.authorIsenberg, David A
dc.contributor.authorRahman, Anisur
dc.contributor.authorGinzler, Ellen M
dc.contributor.authorFortin, Paul
dc.contributor.authorGladman, Dafna D
dc.contributor.authorSanchez-Guerrero, Jorge
dc.contributor.authorPetri, Michelle
dc.contributor.authorBruce, Ian N
dc.contributor.authorDooley, Mary Anne
dc.contributor.authorRamsey-Goldman, Rosalind
dc.contributor.authorAranow, Cynthia
dc.contributor.authorAlarcón, Graciela S
dc.contributor.authorFessler, Barri J
dc.contributor.authorSteinsson, Kristjan
dc.contributor.authorNived, Ola
dc.contributor.authorSturfelt, Gunnar K
dc.contributor.authorManzi, Susan
dc.contributor.authorKhamashta, Munther A
dc.contributor.authorvan Vollenhoven, Ronald F
dc.contributor.authorZoma, Asad A
dc.contributor.authorRamos-Casals, Manuel
dc.contributor.authorRuiz-Irastorza, Guillermo
dc.contributor.authorLim, S Sam
dc.contributor.authorStoll, Thomas
dc.contributor.authorInanc, Murat
dc.contributor.authorKalunian, Kenneth C
dc.contributor.authorKamen, Diane L
dc.contributor.authorMaddison, Peter
dc.contributor.authorPeschken, Christine A
dc.contributor.authorJacobsen, Soren
dc.contributor.authorAskanase, Anca
dc.contributor.authorTheriault, Chris
dc.contributor.authorThompson, Kara
dc.contributor.authorFarewell, Vernon
dc.date.accessioned2023-02-07T17:20:24Z
dc.date.available2023-02-07T17:20:24Z
dc.date.issued2015-09-05
dc.identifier.citationHanly JG, O'Keeffe AG, Su L, Urowitz MB, Romero-Diaz J, Gordon C, Bae SC, Bernatsky S, Clarke AE, Wallace DJ, Merrill JT, Isenberg DA, Rahman A, Ginzler EM, Fortin P, Gladman DD, Sanchez-Guerrero J, Petri M, Bruce IN, Dooley MA, Ramsey-Goldman R, Aranow C, Alarcón GS, Fessler BJ, Steinsson K, Nived O, Sturfelt GK, Manzi S, Khamashta MA, van Vollenhoven RF, Zoma AA, Ramos-Casals M, Ruiz-Irastorza G, Lim SS, Stoll T, Inanc M, Kalunian KC, Kamen DL, Maddison P, Peschken CA, Jacobsen S, Askanase A, Theriault C, Thompson K, Farewell V. The frequency and outcome of lupus nephritis: results from an international inception cohort study. Rheumatology (Oxford). 2016 Feb;55(2):252-62. doi: 10.1093/rheumatology/kev311. Epub 2015 Sep 5. PMID: 26342222; PMCID: PMC4939728.en_US
dc.identifier.eissn1462-0332
dc.identifier.doi10.1093/rheumatology/kev311
dc.identifier.pmid26342222
dc.identifier.urihttp://hdl.handle.net/20.500.12648/8287
dc.description.abstractTo determine nephritis outcomes in a prospective multi-ethnic/racial SLE inception cohort.
dc.description.abstractPatients in the Systemic Lupus International Collaborating Clinics inception cohort (≤15 months of SLE diagnosis) were assessed annually for estimated glomerular filtration rate (eGFR), proteinuria and end-stage renal disease (ESRD). Health-related quality of life was measured by the Short Form (36 questions) health survey questionnaire (SF-36) subscales, mental and physical component summary scores.
dc.description.abstractThere were 1827 patients, 89% females, mean (s.d.) age 35.1 (13.3) years. The mean (s.d.) SLE duration at enrolment was 0.5 (0.3) years and follow-up 4.6 (3.4) years. LN occurred in 700 (38.3%) patients: 566/700 (80.9%) at enrolment and 134/700 (19.1%) during follow-up. Patients with nephritis were younger, more frequently men and of African, Asian and Hispanic race/ethnicity. The estimated overall 10-year incidence of ESRD was 4.3% (95% CI: 2.8%, 5.8%), and with nephritis was 10.1% (95% CI: 6.6%, 13.6%). Patients with nephritis had a higher risk of death (HR = 2.98, 95% CI: 1.48, 5.99; P = 0.002) and those with eGFR <30 ml/min at diagnosis had lower SF-36 physical component summary scores (P < 0.01) and lower Physical function, Physical role and Bodily pain scores. Over time, patients with abnormal eGFR and proteinuria had lower SF-36 mental component summary (P ≤ 0.02) scores compared to patients with normal values.
dc.description.abstractLN occurred in 38.3% of SLE patients, frequently as the initial presentation, in a large multi-ethnic inception cohort. Despite current standard of care, nephritis was associated with ESRD and death, and renal insufficiency was linked to lower health-related quality of life. Further advances are required for the optimal treatment of LN.
dc.language.isoenen_US
dc.relation.urlhttps://academic.oup.com/rheumatology/article/55/2/252/1822307en_US
dc.rights© The Author 2015. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For Permissions, please email: journals.permissions@oup.com.
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectinception cohorten_US
dc.subjectlupusen_US
dc.subjectnephritisen_US
dc.subjectoutcomes researchen_US
dc.subjectsystemic lupus erythematosusen_US
dc.titleThe frequency and outcome of lupus nephritis: results from an international inception cohort study.en_US
dc.typeArticle/Reviewen_US
dc.source.journaltitleRheumatology (Oxford, England)en_US
dc.source.volume55
dc.source.issue2
dc.source.beginpage252
dc.source.endpage62
dc.source.countryUnited Kingdom
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryEngland
dc.description.versionVoRen_US
refterms.dateFOA2023-02-07T17:20:25Z
html.description.abstractTo determine nephritis outcomes in a prospective multi-ethnic/racial SLE inception cohort.
html.description.abstractPatients in the Systemic Lupus International Collaborating Clinics inception cohort (≤15 months of SLE diagnosis) were assessed annually for estimated glomerular filtration rate (eGFR), proteinuria and end-stage renal disease (ESRD). Health-related quality of life was measured by the Short Form (36 questions) health survey questionnaire (SF-36) subscales, mental and physical component summary scores.
html.description.abstractThere were 1827 patients, 89% females, mean (s.d.) age 35.1 (13.3) years. The mean (s.d.) SLE duration at enrolment was 0.5 (0.3) years and follow-up 4.6 (3.4) years. LN occurred in 700 (38.3%) patients: 566/700 (80.9%) at enrolment and 134/700 (19.1%) during follow-up. Patients with nephritis were younger, more frequently men and of African, Asian and Hispanic race/ethnicity. The estimated overall 10-year incidence of ESRD was 4.3% (95% CI: 2.8%, 5.8%), and with nephritis was 10.1% (95% CI: 6.6%, 13.6%). Patients with nephritis had a higher risk of death (HR = 2.98, 95% CI: 1.48, 5.99; P = 0.002) and those with eGFR <30 ml/min at diagnosis had lower SF-36 physical component summary scores (P < 0.01) and lower Physical function, Physical role and Bodily pain scores. Over time, patients with abnormal eGFR and proteinuria had lower SF-36 mental component summary (P ≤ 0.02) scores compared to patients with normal values.
html.description.abstractLN occurred in 38.3% of SLE patients, frequently as the initial presentation, in a large multi-ethnic inception cohort. Despite current standard of care, nephritis was associated with ESRD and death, and renal insufficiency was linked to lower health-related quality of life. Further advances are required for the optimal treatment of LN.
dc.description.institutionSUNY Downstateen_US
dc.description.departmentRheumatologyen_US
dc.description.degreelevelN/Aen_US
dc.identifier.journalRheumatology (Oxford, England)


Files in this item

Thumbnail
Name:
kev311.pdf
Size:
263.8Kb
Format:
PDF

This item appears in the following Collection(s)

Show simple item record

© The Author 2015. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For Permissions, please email: journals.permissions@oup.com.
Except where otherwise noted, this item's license is described as © The Author 2015. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For Permissions, please email: journals.permissions@oup.com.