25-hydroxyvitamin D and cardiovascular disease in patients with systemic lupus erythematosus: data from a large international inception cohort.
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Author
Lertratanakul, ApinyaWu, Peggy
Dyer, Alan
Urowitz, Murray
Gladman, Dafna
Fortin, Paul
Bae, Sang-Cheol
Gordon, Caroline
Clarke, Ann
Bernatsky, Sasha
Hanly, John G
Isenberg, David
Rahman, Anisur
Merrill, Joan
Wallace, Daniel J
Ginzler, Ellen
Khamashta, Munther
Bruce, Ian
Nived, Ola
Sturfelt, Gunnar
Steinsson, Kristjan
Manzi, Susan
Dooley, Mary Anne
Kalunian, Kenneth
Petri, Michelle
Aranow, Cynthia
Font, Josep
van Vollenhoven, Ronald
Stoll, Thomas
Ramsey-Goldman, Rosalind
Journal title
Arthritis care & researchDate Published
2014-08Publication Volume
66Publication Issue
8Publication Begin page
1167Publication End page
76
Metadata
Show full item recordAbstract
An association between 25-hydroxyvitamin D (25[OH]D; vitamin D) deficiency and increased cardiovascular (CV) risk factors and CV disease (CVD) has been shown in general population studies. Vitamin D deficiency has been noted in systemic lupus erythematosus (SLE), and CVD is a major cause of morbidity and mortality in SLE. The objectives of this study were to estimate the associations of 25(OH)D levels with CV risk factors and to determine whether low baseline 25(OH)D levels predict future CV events in patients participating in an international inception cohort.Data were collected on 890 participants, including demographics, SLE activity and damage assessments, CV risk factors and events, medications, laboratory assessments of 25(OH)D levels, and inflammatory markers. Multiple logistic and Cox regressions were used to estimate the associations of baseline 25(OH)D levels with baseline CV risk factors and CVD events. The models were adjusted for age, sex, race, season, and country, with and without body mass index.
Patients in the higher quartiles of 25(OH)D were less likely to have hypertension and hyperlipidemia and were more likely to have lower C-reactive protein levels and lower Systemic Lupus Erythematosus Disease Activity Index 2000 scores at baseline when compared with the first quartile. Vitamin D levels were not independently associated with CVD event incidence; however, hazard ratios for CVD event incidence decreased with successively higher quartiles.
Lower baseline 25(OH)D levels are associated with higher risk for CV risk factors and more active SLE at baseline. There may be a trend toward a lower likelihood of CVD events in those with higher baseline 25(OH)D levels.
Citation
Lertratanakul A, Wu P, Dyer A, Urowitz M, Gladman D, Fortin P, Bae SC, Gordon C, Clarke A, Bernatsky S, Hanly JG, Isenberg D, Rahman A, Merrill J, Wallace DJ, Ginzler E, Khamashta M, Bruce I, Nived O, Sturfelt G, Steinsson K, Manzi S, Dooley MA, Kalunian K, Petri M, Aranow C, Font J, van Vollenhoven R, Stoll T, Ramsey-Goldman R. 25-hydroxyvitamin D and cardiovascular disease in patients with systemic lupus erythematosus: data from a large international inception cohort. Arthritis Care Res (Hoboken). 2014 Aug;66(8):1167-76. doi: 10.1002/acr.22291. PMID: 24470118; PMCID: PMC4844829.DOI
10.1002/acr.22291ae974a485f413a2113503eed53cd6c53
10.1002/acr.22291
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The following license files are associated with this item:
- Creative Commons
Except where otherwise noted, this item's license is described as Copyright © 2014 by the American College of Rheumatology.
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