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dc.contributor.authorBernatsky, Sasha
dc.contributor.authorRamsey-Goldman, Rosalind
dc.contributor.authorLabrecque, Jeremy
dc.contributor.authorJoseph, Lawrence
dc.contributor.authorBoivin, Jean-Francois
dc.contributor.authorPetri, Michelle
dc.contributor.authorZoma, Asad
dc.contributor.authorManzi, Susan
dc.contributor.authorUrowitz, Murray B
dc.contributor.authorGladman, Dafna
dc.contributor.authorFortin, Paul R
dc.contributor.authorGinzler, Ellen
dc.contributor.authorYelin, Edward
dc.contributor.authorBae, Sang-Cheol
dc.contributor.authorWallace, Daniel J
dc.contributor.authorEdworthy, Steven
dc.contributor.authorJacobsen, Soren
dc.contributor.authorGordon, Caroline
dc.contributor.authorDooley, Mary Anne
dc.contributor.authorPeschken, Christine A
dc.contributor.authorHanly, John G
dc.contributor.authorAlarcón, Graciela S
dc.contributor.authorNived, Ola
dc.contributor.authorRuiz-Irastorza, Guillermo
dc.contributor.authorIsenberg, David
dc.contributor.authorRahman, Anisur
dc.contributor.authorWitte, Torsten
dc.contributor.authorAranow, Cynthia
dc.contributor.authorKamen, Diane L
dc.contributor.authorSteinsson, Kristjan
dc.contributor.authorAskanase, Anca
dc.contributor.authorBarr, Susan
dc.contributor.authorCriswell, Lindsey A
dc.contributor.authorSturfelt, Gunnar
dc.contributor.authorPatel, Neha M
dc.contributor.authorSenécal, Jean-Luc
dc.contributor.authorZummer, Michel
dc.contributor.authorPope, Janet E
dc.contributor.authorEnsworth, Stephanie
dc.contributor.authorEl-Gabalawy, Hani
dc.contributor.authorMcCarthy, Timothy
dc.contributor.authorDreyer, Lene
dc.contributor.authorSibley, John
dc.contributor.authorSt Pierre, Yvan
dc.contributor.authorClarke, Ann E
dc.date.accessioned2023-02-06T20:29:22Z
dc.date.available2023-02-06T20:29:22Z
dc.date.issued2013-02-12
dc.identifier.citationBernatsky S, Ramsey-Goldman R, Labrecque J, Joseph L, Boivin JF, Petri M, Zoma A, Manzi S, Urowitz MB, Gladman D, Fortin PR, Ginzler E, Yelin E, Bae SC, Wallace DJ, Edworthy S, Jacobsen S, Gordon C, Dooley MA, Peschken CA, Hanly JG, Alarcón GS, Nived O, Ruiz-Irastorza G, Isenberg D, Rahman A, Witte T, Aranow C, Kamen DL, Steinsson K, Askanase A, Barr S, Criswell LA, Sturfelt G, Patel NM, Senécal JL, Zummer M, Pope JE, Ensworth S, El-Gabalawy H, McCarthy T, Dreyer L, Sibley J, St Pierre Y, Clarke AE. Cancer risk in systemic lupus: an updated international multi-centre cohort study. J Autoimmun. 2013 May;42:130-5. doi: 10.1016/j.jaut.2012.12.009. Epub 2013 Feb 12. PMID: 23410586; PMCID: PMC3646904.en_US
dc.identifier.eissn1095-9157
dc.identifier.doi10.1016/j.jaut.2012.12.009
dc.identifier.pmid23410586
dc.identifier.urihttp://hdl.handle.net/20.500.12648/8259
dc.description.abstractTo update estimates of cancer risk in SLE relative to the general population.
dc.description.abstractA multisite international SLE cohort was linked with regional tumor registries. Standardized incidence ratios (SIRs) were calculated as the ratio of observed to expected cancers.
dc.description.abstractAcross 30 centres, 16,409 patients were observed for 121,283 (average 7.4) person-years. In total, 644 cancers occurred. Some cancers, notably hematologic malignancies, were substantially increased (SIR 3.02, 95% confidence interval, CI, 2.48, 3.63), particularly non-Hodgkin's lymphoma, NHL (SIR 4.39, 95% CI 3.46, 5.49) and leukemia. In addition, increased risks of cancer of the vulva (SIR 3.78, 95% CI 1.52, 7.78), lung (SIR 1.30, 95% CI 1.04, 1.60), thyroid (SIR 1.76, 95% CI 1.13, 2.61) and possibly liver (SIR 1.87, 95% CI 0.97, 3.27) were suggested. However, a decreased risk was estimated for breast (SIR 0.73, 95% CI 0.61-0.88), endometrial (SIR 0.44, 95% CI 0.23-0.77), and possibly ovarian cancers (0.64, 95% CI 0.34-1.10). The variability of comparative rates across different cancers meant that only a small increased risk was estimated across all cancers (SIR 1.14, 95% CI 1.05, 1.23).
dc.description.abstractThese data estimate only a small increased risk in SLE (versus the general population) for cancer over-all. However, there is clearly an increased risk of NHL, and cancers of the vulva, lung, thyroid, and possibly liver. It remains unclear to what extent the association with NHL is mediated by innate versus exogenous factors. Similarly, the etiology of the decreased breast, endometrial, and possibly ovarian cancer risk is uncertain, though investigations are ongoing.
dc.language.isoenen_US
dc.relation.urlhttps://www.sciencedirect.com/science/article/abs/pii/S0896841113000115?via%3Dihuben_US
dc.rightsCopyright © 2013 Elsevier Ltd. All rights reserved.
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.titleCancer risk in systemic lupus: an updated international multi-centre cohort study.en_US
dc.typeArticle/Reviewen_US
dc.source.journaltitleJournal of autoimmunityen_US
dc.source.volume42
dc.source.beginpage130
dc.source.endpage5
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryEngland
dc.description.versionAMen_US
refterms.dateFOA2023-02-06T20:29:22Z
html.description.abstractTo update estimates of cancer risk in SLE relative to the general population.
html.description.abstractA multisite international SLE cohort was linked with regional tumor registries. Standardized incidence ratios (SIRs) were calculated as the ratio of observed to expected cancers.
html.description.abstractAcross 30 centres, 16,409 patients were observed for 121,283 (average 7.4) person-years. In total, 644 cancers occurred. Some cancers, notably hematologic malignancies, were substantially increased (SIR 3.02, 95% confidence interval, CI, 2.48, 3.63), particularly non-Hodgkin's lymphoma, NHL (SIR 4.39, 95% CI 3.46, 5.49) and leukemia. In addition, increased risks of cancer of the vulva (SIR 3.78, 95% CI 1.52, 7.78), lung (SIR 1.30, 95% CI 1.04, 1.60), thyroid (SIR 1.76, 95% CI 1.13, 2.61) and possibly liver (SIR 1.87, 95% CI 0.97, 3.27) were suggested. However, a decreased risk was estimated for breast (SIR 0.73, 95% CI 0.61-0.88), endometrial (SIR 0.44, 95% CI 0.23-0.77), and possibly ovarian cancers (0.64, 95% CI 0.34-1.10). The variability of comparative rates across different cancers meant that only a small increased risk was estimated across all cancers (SIR 1.14, 95% CI 1.05, 1.23).
html.description.abstractThese data estimate only a small increased risk in SLE (versus the general population) for cancer over-all. However, there is clearly an increased risk of NHL, and cancers of the vulva, lung, thyroid, and possibly liver. It remains unclear to what extent the association with NHL is mediated by innate versus exogenous factors. Similarly, the etiology of the decreased breast, endometrial, and possibly ovarian cancer risk is uncertain, though investigations are ongoing.
dc.description.institutionSUNY Downstateen_US
dc.description.departmentRheumatologyen_US
dc.description.degreelevelN/Aen_US
dc.identifier.journalJournal of autoimmunity


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Copyright © 2013 Elsevier Ltd. All rights reserved.
Except where otherwise noted, this item's license is described as Copyright © 2013 Elsevier Ltd. All rights reserved.