Clinical associations of the metabolic syndrome in systemic lupus erythematosus: data from an international inception cohort.
dc.contributor.author | Parker, Ben | |
dc.contributor.author | Urowitz, Murray B | |
dc.contributor.author | Gladman, Dafna D | |
dc.contributor.author | Lunt, Mark | |
dc.contributor.author | Bae, Sang-Cheol | |
dc.contributor.author | Sanchez-Guerrero, Jorge | |
dc.contributor.author | Romero-Diaz, Juanita | |
dc.contributor.author | Gordon, Caroline | |
dc.contributor.author | Wallace, Daniel J | |
dc.contributor.author | Clarke, Ann E | |
dc.contributor.author | Bernatsky, Sasha | |
dc.contributor.author | Ginzler, Ellen M | |
dc.contributor.author | Isenberg, David A | |
dc.contributor.author | Rahman, Anisur | |
dc.contributor.author | Merrill, Joan T | |
dc.contributor.author | Alarcón, Graciela S | |
dc.contributor.author | Fessler, Barri J | |
dc.contributor.author | Fortin, Paul R | |
dc.contributor.author | Hanly, John G | |
dc.contributor.author | Petri, Michelle | |
dc.contributor.author | Steinsson, Kristjan | |
dc.contributor.author | Dooley, Mary-Anne | |
dc.contributor.author | Manzi, Susan | |
dc.contributor.author | Khamashta, Munther A | |
dc.contributor.author | Ramsey-Goldman, Rosalind | |
dc.contributor.author | Zoma, Asad A | |
dc.contributor.author | Sturfelt, Gunnar K | |
dc.contributor.author | Nived, Ola | |
dc.contributor.author | Aranow, Cynthia | |
dc.contributor.author | Mackay, Meggan | |
dc.contributor.author | Ramos-Casals, Manuel | |
dc.contributor.author | van Vollenhoven, Raymond F | |
dc.contributor.author | Kalunian, Kenneth C | |
dc.contributor.author | Ruiz-Irastorza, Guillermo | |
dc.contributor.author | Lim, Sam | |
dc.contributor.author | Kamen, Diane L | |
dc.contributor.author | Peschken, Christine A | |
dc.contributor.author | Inanc, Murat | |
dc.contributor.author | Bruce, Ian N | |
dc.date.accessioned | 2023-02-06T20:25:08Z | |
dc.date.available | 2023-02-06T20:25:08Z | |
dc.date.issued | 2012-09-03 | |
dc.identifier.citation | Parker B, Urowitz MB, Gladman DD, Lunt M, Bae SC, Sanchez-Guerrero J, Romero-Diaz J, Gordon C, Wallace DJ, Clarke AE, Bernatsky S, Ginzler EM, Isenberg DA, Rahman A, Merrill JT, Alarcón GS, Fessler BJ, Fortin PR, Hanly JG, Petri M, Steinsson K, Dooley MA, Manzi S, Khamashta MA, Ramsey-Goldman R, Zoma AA, Sturfelt GK, Nived O, Aranow C, Mackay M, Ramos-Casals M, van Vollenhoven RF, Kalunian KC, Ruiz-Irastorza G, Lim S, Kamen DL, Peschken CA, Inanc M, Bruce IN. Clinical associations of the metabolic syndrome in systemic lupus erythematosus: data from an international inception cohort. Ann Rheum Dis. 2013 Aug;72(8):1308-14. doi: 10.1136/annrheumdis-2012-202106. Epub 2012 Sep 3. Erratum in: Ann Rheum Dis. 2014 Jan;73(1):320. PMID: 22945501; PMCID: PMC3711497. | en_US |
dc.identifier.eissn | 1468-2060 | |
dc.identifier.doi | 10.1136/annrheumdis-2012-202106 | |
dc.identifier.pmid | 22945501 | |
dc.identifier.uri | http://hdl.handle.net/20.500.12648/8258 | |
dc.description.abstract | The metabolic syndrome (MetS) may contribute to increased cardiovascular risk in systemic lupus erythematosus (SLE). We aimed to examine the association of demographic factors, lupus phenotype and therapy exposure with the presence of MetS. | |
dc.description.abstract | The Systemic Lupus International Collaborating Clinics Registry for Atherosclerosis inception cohort enrolled recently diagnosed (<15 months) SLE patients from 30 centres across 11 countries from 2000. Clinical, laboratory and therapeutic data were collected according to a standardised protocol. MetS was defined according to the 2009 consensus statement from the International Diabetes Federation. Univariate and backward stepwise multivariate logistic regression were used to assess the relationship of individual variables with MetS. | |
dc.description.abstract | We studied 1686 patients, of whom 1494 (86.6%) had sufficient data to determine their MetS status. The mean (SD) age at enrolment and disease duration was 35.2 years (13.4) and 24.1 weeks (18.0), respectively. MetS was present at the enrolment visit in 239 (16%). In backward stepwise multivariable regression analysis, higher daily average prednisolone dose (mg) (OR 1.02, 95% CI 1.00 to 1.03), older age (years) (OR 1.04, 95% CI 1.03 to 1.06), Korean (OR 6.33, 95% CI 3.68 to 10.86) and Hispanic (OR 6.2, 95% CI 3.78 to 10.12) ethnicity, current renal disease (OR 1.79, 95% CI 1.14 to 2.80) and immunosuppressant use (OR 1.81, 95% CI 1.18 to 2.78) were associated with MetS. | |
dc.description.abstract | Renal lupus, higher corticosteroid doses, Korean and Hispanic ethnicity are associated with MetS in SLE patients. Balancing disease control and minimising corticosteroid exposure should therefore be at the forefront of personalised treatment decisions in SLE patients. | |
dc.language.iso | en | en_US |
dc.relation.url | https://ard.bmj.com/content/72/8/1308.long | en_US |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 International | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Cardiovascular Disease | en_US |
dc.subject | Epidemiology | en_US |
dc.subject | Inflammation | en_US |
dc.subject | Systemic Lupus Erythematosus | en_US |
dc.title | Clinical associations of the metabolic syndrome in systemic lupus erythematosus: data from an international inception cohort. | en_US |
dc.type | Article/Review | en_US |
dc.source.journaltitle | Annals of the rheumatic diseases | en_US |
dc.source.volume | 72 | |
dc.source.issue | 8 | |
dc.source.beginpage | 1308 | |
dc.source.endpage | 14 | |
dc.source.country | United States | |
dc.source.country | United States | |
dc.source.country | United States | |
dc.source.country | United Kingdom | |
dc.source.country | United States | |
dc.source.country | United Kingdom | |
dc.source.country | United States | |
dc.source.country | United States | |
dc.source.country | Canada | |
dc.source.country | United States | |
dc.source.country | England | |
dc.description.version | VoR | en_US |
refterms.dateFOA | 2023-02-06T20:25:09Z | |
html.description.abstract | The metabolic syndrome (MetS) may contribute to increased cardiovascular risk in systemic lupus erythematosus (SLE). We aimed to examine the association of demographic factors, lupus phenotype and therapy exposure with the presence of MetS. | |
html.description.abstract | The Systemic Lupus International Collaborating Clinics Registry for Atherosclerosis inception cohort enrolled recently diagnosed (<15 months) SLE patients from 30 centres across 11 countries from 2000. Clinical, laboratory and therapeutic data were collected according to a standardised protocol. MetS was defined according to the 2009 consensus statement from the International Diabetes Federation. Univariate and backward stepwise multivariate logistic regression were used to assess the relationship of individual variables with MetS. | |
html.description.abstract | We studied 1686 patients, of whom 1494 (86.6%) had sufficient data to determine their MetS status. The mean (SD) age at enrolment and disease duration was 35.2 years (13.4) and 24.1 weeks (18.0), respectively. MetS was present at the enrolment visit in 239 (16%). In backward stepwise multivariable regression analysis, higher daily average prednisolone dose (mg) (OR 1.02, 95% CI 1.00 to 1.03), older age (years) (OR 1.04, 95% CI 1.03 to 1.06), Korean (OR 6.33, 95% CI 3.68 to 10.86) and Hispanic (OR 6.2, 95% CI 3.78 to 10.12) ethnicity, current renal disease (OR 1.79, 95% CI 1.14 to 2.80) and immunosuppressant use (OR 1.81, 95% CI 1.18 to 2.78) were associated with MetS. | |
html.description.abstract | Renal lupus, higher corticosteroid doses, Korean and Hispanic ethnicity are associated with MetS in SLE patients. Balancing disease control and minimising corticosteroid exposure should therefore be at the forefront of personalised treatment decisions in SLE patients. | |
dc.description.institution | SUNY Downstate | en_US |
dc.description.department | Rheumatology | en_US |
dc.description.degreelevel | N/A | en_US |
dc.identifier.journal | Annals of the rheumatic diseases |