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dc.contributor.authorParker, Ben
dc.contributor.authorUrowitz, Murray B
dc.contributor.authorGladman, Dafna D
dc.contributor.authorLunt, Mark
dc.contributor.authorBae, Sang-Cheol
dc.contributor.authorSanchez-Guerrero, Jorge
dc.contributor.authorRomero-Diaz, Juanita
dc.contributor.authorGordon, Caroline
dc.contributor.authorWallace, Daniel J
dc.contributor.authorClarke, Ann E
dc.contributor.authorBernatsky, Sasha
dc.contributor.authorGinzler, Ellen M
dc.contributor.authorIsenberg, David A
dc.contributor.authorRahman, Anisur
dc.contributor.authorMerrill, Joan T
dc.contributor.authorAlarcón, Graciela S
dc.contributor.authorFessler, Barri J
dc.contributor.authorFortin, Paul R
dc.contributor.authorHanly, John G
dc.contributor.authorPetri, Michelle
dc.contributor.authorSteinsson, Kristjan
dc.contributor.authorDooley, Mary-Anne
dc.contributor.authorManzi, Susan
dc.contributor.authorKhamashta, Munther A
dc.contributor.authorRamsey-Goldman, Rosalind
dc.contributor.authorZoma, Asad A
dc.contributor.authorSturfelt, Gunnar K
dc.contributor.authorNived, Ola
dc.contributor.authorAranow, Cynthia
dc.contributor.authorMackay, Meggan
dc.contributor.authorRamos-Casals, Manuel
dc.contributor.authorvan Vollenhoven, Raymond F
dc.contributor.authorKalunian, Kenneth C
dc.contributor.authorRuiz-Irastorza, Guillermo
dc.contributor.authorLim, Sam
dc.contributor.authorKamen, Diane L
dc.contributor.authorPeschken, Christine A
dc.contributor.authorInanc, Murat
dc.contributor.authorBruce, Ian N
dc.date.accessioned2023-02-06T20:25:08Z
dc.date.available2023-02-06T20:25:08Z
dc.date.issued2012-09-03
dc.identifier.citationParker B, Urowitz MB, Gladman DD, Lunt M, Bae SC, Sanchez-Guerrero J, Romero-Diaz J, Gordon C, Wallace DJ, Clarke AE, Bernatsky S, Ginzler EM, Isenberg DA, Rahman A, Merrill JT, Alarcón GS, Fessler BJ, Fortin PR, Hanly JG, Petri M, Steinsson K, Dooley MA, Manzi S, Khamashta MA, Ramsey-Goldman R, Zoma AA, Sturfelt GK, Nived O, Aranow C, Mackay M, Ramos-Casals M, van Vollenhoven RF, Kalunian KC, Ruiz-Irastorza G, Lim S, Kamen DL, Peschken CA, Inanc M, Bruce IN. Clinical associations of the metabolic syndrome in systemic lupus erythematosus: data from an international inception cohort. Ann Rheum Dis. 2013 Aug;72(8):1308-14. doi: 10.1136/annrheumdis-2012-202106. Epub 2012 Sep 3. Erratum in: Ann Rheum Dis. 2014 Jan;73(1):320. PMID: 22945501; PMCID: PMC3711497.en_US
dc.identifier.eissn1468-2060
dc.identifier.doi10.1136/annrheumdis-2012-202106
dc.identifier.pmid22945501
dc.identifier.urihttp://hdl.handle.net/20.500.12648/8258
dc.description.abstractThe metabolic syndrome (MetS) may contribute to increased cardiovascular risk in systemic lupus erythematosus (SLE). We aimed to examine the association of demographic factors, lupus phenotype and therapy exposure with the presence of MetS.
dc.description.abstractThe Systemic Lupus International Collaborating Clinics Registry for Atherosclerosis inception cohort enrolled recently diagnosed (<15 months) SLE patients from 30 centres across 11 countries from 2000. Clinical, laboratory and therapeutic data were collected according to a standardised protocol. MetS was defined according to the 2009 consensus statement from the International Diabetes Federation. Univariate and backward stepwise multivariate logistic regression were used to assess the relationship of individual variables with MetS.
dc.description.abstractWe studied 1686 patients, of whom 1494 (86.6%) had sufficient data to determine their MetS status. The mean (SD) age at enrolment and disease duration was 35.2 years (13.4) and 24.1 weeks (18.0), respectively. MetS was present at the enrolment visit in 239 (16%). In backward stepwise multivariable regression analysis, higher daily average prednisolone dose (mg) (OR 1.02, 95% CI 1.00 to 1.03), older age (years) (OR 1.04, 95% CI 1.03 to 1.06), Korean (OR 6.33, 95% CI 3.68 to 10.86) and Hispanic (OR 6.2, 95% CI 3.78 to 10.12) ethnicity, current renal disease (OR 1.79, 95% CI 1.14 to 2.80) and immunosuppressant use (OR 1.81, 95% CI 1.18 to 2.78) were associated with MetS.
dc.description.abstractRenal lupus, higher corticosteroid doses, Korean and Hispanic ethnicity are associated with MetS in SLE patients. Balancing disease control and minimising corticosteroid exposure should therefore be at the forefront of personalised treatment decisions in SLE patients.
dc.language.isoenen_US
dc.relation.urlhttps://ard.bmj.com/content/72/8/1308.longen_US
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectCardiovascular Diseaseen_US
dc.subjectEpidemiologyen_US
dc.subjectInflammationen_US
dc.subjectSystemic Lupus Erythematosusen_US
dc.titleClinical associations of the metabolic syndrome in systemic lupus erythematosus: data from an international inception cohort.en_US
dc.typeArticle/Reviewen_US
dc.source.journaltitleAnnals of the rheumatic diseasesen_US
dc.source.volume72
dc.source.issue8
dc.source.beginpage1308
dc.source.endpage14
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited Kingdom
dc.source.countryUnited States
dc.source.countryUnited Kingdom
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryCanada
dc.source.countryUnited States
dc.source.countryEngland
dc.description.versionVoRen_US
refterms.dateFOA2023-02-06T20:25:09Z
html.description.abstractThe metabolic syndrome (MetS) may contribute to increased cardiovascular risk in systemic lupus erythematosus (SLE). We aimed to examine the association of demographic factors, lupus phenotype and therapy exposure with the presence of MetS.
html.description.abstractThe Systemic Lupus International Collaborating Clinics Registry for Atherosclerosis inception cohort enrolled recently diagnosed (<15 months) SLE patients from 30 centres across 11 countries from 2000. Clinical, laboratory and therapeutic data were collected according to a standardised protocol. MetS was defined according to the 2009 consensus statement from the International Diabetes Federation. Univariate and backward stepwise multivariate logistic regression were used to assess the relationship of individual variables with MetS.
html.description.abstractWe studied 1686 patients, of whom 1494 (86.6%) had sufficient data to determine their MetS status. The mean (SD) age at enrolment and disease duration was 35.2 years (13.4) and 24.1 weeks (18.0), respectively. MetS was present at the enrolment visit in 239 (16%). In backward stepwise multivariable regression analysis, higher daily average prednisolone dose (mg) (OR 1.02, 95% CI 1.00 to 1.03), older age (years) (OR 1.04, 95% CI 1.03 to 1.06), Korean (OR 6.33, 95% CI 3.68 to 10.86) and Hispanic (OR 6.2, 95% CI 3.78 to 10.12) ethnicity, current renal disease (OR 1.79, 95% CI 1.14 to 2.80) and immunosuppressant use (OR 1.81, 95% CI 1.18 to 2.78) were associated with MetS.
html.description.abstractRenal lupus, higher corticosteroid doses, Korean and Hispanic ethnicity are associated with MetS in SLE patients. Balancing disease control and minimising corticosteroid exposure should therefore be at the forefront of personalised treatment decisions in SLE patients.
dc.description.institutionSUNY Downstateen_US
dc.description.departmentRheumatologyen_US
dc.description.degreelevelN/Aen_US
dc.identifier.journalAnnals of the rheumatic diseases


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