Clinical associations of the metabolic syndrome in systemic lupus erythematosus: data from an international inception cohort.
Average rating
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Star rating
Your vote was cast
Thank you for your feedback
Thank you for your feedback
Author
Parker, BenUrowitz, Murray B
Gladman, Dafna D
Lunt, Mark
Bae, Sang-Cheol
Sanchez-Guerrero, Jorge
Romero-Diaz, Juanita
Gordon, Caroline
Wallace, Daniel J
Clarke, Ann E
Bernatsky, Sasha
Ginzler, Ellen M
Isenberg, David A
Rahman, Anisur
Merrill, Joan T
Alarcón, Graciela S
Fessler, Barri J
Fortin, Paul R
Hanly, John G
Petri, Michelle
Steinsson, Kristjan
Dooley, Mary-Anne
Manzi, Susan
Khamashta, Munther A
Ramsey-Goldman, Rosalind
Zoma, Asad A
Sturfelt, Gunnar K
Nived, Ola
Aranow, Cynthia
Mackay, Meggan
Ramos-Casals, Manuel
van Vollenhoven, Raymond F
Kalunian, Kenneth C
Ruiz-Irastorza, Guillermo
Lim, Sam
Kamen, Diane L
Peschken, Christine A
Inanc, Murat
Bruce, Ian N
Journal title
Annals of the rheumatic diseasesDate Published
2012-09-03Publication Volume
72Publication Issue
8Publication Begin page
1308Publication End page
14
Metadata
Show full item recordAbstract
The metabolic syndrome (MetS) may contribute to increased cardiovascular risk in systemic lupus erythematosus (SLE). We aimed to examine the association of demographic factors, lupus phenotype and therapy exposure with the presence of MetS.The Systemic Lupus International Collaborating Clinics Registry for Atherosclerosis inception cohort enrolled recently diagnosed (<15 months) SLE patients from 30 centres across 11 countries from 2000. Clinical, laboratory and therapeutic data were collected according to a standardised protocol. MetS was defined according to the 2009 consensus statement from the International Diabetes Federation. Univariate and backward stepwise multivariate logistic regression were used to assess the relationship of individual variables with MetS.
We studied 1686 patients, of whom 1494 (86.6%) had sufficient data to determine their MetS status. The mean (SD) age at enrolment and disease duration was 35.2 years (13.4) and 24.1 weeks (18.0), respectively. MetS was present at the enrolment visit in 239 (16%). In backward stepwise multivariable regression analysis, higher daily average prednisolone dose (mg) (OR 1.02, 95% CI 1.00 to 1.03), older age (years) (OR 1.04, 95% CI 1.03 to 1.06), Korean (OR 6.33, 95% CI 3.68 to 10.86) and Hispanic (OR 6.2, 95% CI 3.78 to 10.12) ethnicity, current renal disease (OR 1.79, 95% CI 1.14 to 2.80) and immunosuppressant use (OR 1.81, 95% CI 1.18 to 2.78) were associated with MetS.
Renal lupus, higher corticosteroid doses, Korean and Hispanic ethnicity are associated with MetS in SLE patients. Balancing disease control and minimising corticosteroid exposure should therefore be at the forefront of personalised treatment decisions in SLE patients.
Citation
Parker B, Urowitz MB, Gladman DD, Lunt M, Bae SC, Sanchez-Guerrero J, Romero-Diaz J, Gordon C, Wallace DJ, Clarke AE, Bernatsky S, Ginzler EM, Isenberg DA, Rahman A, Merrill JT, Alarcón GS, Fessler BJ, Fortin PR, Hanly JG, Petri M, Steinsson K, Dooley MA, Manzi S, Khamashta MA, Ramsey-Goldman R, Zoma AA, Sturfelt GK, Nived O, Aranow C, Mackay M, Ramos-Casals M, van Vollenhoven RF, Kalunian KC, Ruiz-Irastorza G, Lim S, Kamen DL, Peschken CA, Inanc M, Bruce IN. Clinical associations of the metabolic syndrome in systemic lupus erythematosus: data from an international inception cohort. Ann Rheum Dis. 2013 Aug;72(8):1308-14. doi: 10.1136/annrheumdis-2012-202106. Epub 2012 Sep 3. Erratum in: Ann Rheum Dis. 2014 Jan;73(1):320. PMID: 22945501; PMCID: PMC3711497.DOI
10.1136/annrheumdis-2012-202106ae974a485f413a2113503eed53cd6c53
10.1136/annrheumdis-2012-202106
Scopus Count
Collections
The following license files are associated with this item:
- Creative Commons
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivatives 4.0 International
Related articles
- Impact of early disease factors on metabolic syndrome in systemic lupus erythematosus: data from an international inception cohort.
- Authors: Parker B, Urowitz MB, Gladman DD, Lunt M, Donn R, Bae SC, Sanchez-Guerrero J, Romero-Diaz J, Gordon C, Wallace DJ, Clarke AE, Bernatsky S, Ginzler EM, Isenberg DA, Rahman A, Merrill JT, Alarcón GS, Fessler BJ, Fortin PR, Hanly JG, Petri M, Steinsson K, Dooley MA, Manzi S, Khamashta MA, Ramsey-Goldman R, Zoma AA, Sturfelt GK, Nived O, Aranow C, Mackay M, Ramos-Casals M, van Vollenhoven RF, Kalunian KC, Ruiz-Irastorza G, Lim SS, Kamen DL, Peschken CA, Inanc M, Bruce IN
- Issue date: 2015 Aug
- Lower vitamin D is associated with metabolic syndrome and insulin resistance in systemic lupus: data from an international inception cohort.
- Authors: Chew C, Reynolds JA, Lertratanakul A, Wu P, Urowitz M, Gladman DD, Fortin PR, Bae SC, Gordon C, Clarke AE, Bernatsky S, Hanly JG, Isenberg D, Rahman A, Sanchez-Guerrero J, Romero-Diaz J, Merrill J, Wallace D, Ginzler E, Khamashta M, Nived O, Jönsen A, Steinsson K, Manzi S, Kalunian K, Dooley MA, Petri M, Aranow C, van Vollenhoven R, Stoll T, Alarcón GS, Lim SS, Ruiz-Irastorza G, Peschken CA, Askanase AD, Kamen DL, İnanç M, Ramsey-Goldman R, Bruce IN
- Issue date: 2021 Oct 2
- Metabolic syndrome in patients with systemic lupus erythematosus: Association with disease activity, disease damage and age.
- Authors: Mobini M, Niksolat F, Mohammadpour RA, Dashti Dargahloo S, Marzban D
- Issue date: 2018 May
- Prevalence of metabolic syndrome in a cohort of systemic lupus erythematosus patients from Northeastern Brazil: association with disease activity, nephritis, smoking, and age.
- Authors: Medeiros MM, Xavier de Oliveira ÍM, Ribeiro ÁT
- Issue date: 2016 Jan
- Prevalence and features of metabolic syndrome in childhood-onset systemic lupus erythematosus.
- Authors: Sinicato NA, Postal M, de Oliveira Peliçari K, Rittner L, Marini R, Appenzeller S
- Issue date: 2017 Jul