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dc.contributor.authorHanly, J G
dc.contributor.authorUrowitz, M B
dc.contributor.authorSanchez-Guerrero, J
dc.contributor.authorBae, S C
dc.contributor.authorGordon, C
dc.contributor.authorWallace, D J
dc.contributor.authorIsenberg, D
dc.contributor.authorAlarcón, G S
dc.contributor.authorClarke, A
dc.contributor.authorBernatsky, S
dc.contributor.authorMerrill, J T
dc.contributor.authorPetri, M
dc.contributor.authorDooley, M A
dc.contributor.authorGladman, D
dc.contributor.authorFortin, P R
dc.contributor.authorSteinsson, K
dc.contributor.authorBruce, I
dc.contributor.authorManzi, S
dc.contributor.authorKhamashta, M
dc.contributor.authorZoma, A
dc.contributor.authorAranow, C
dc.contributor.authorGinzler, E
dc.contributor.authorVan Vollenhoven, R
dc.contributor.authorFont, J
dc.contributor.authorSturfelt, G
dc.contributor.authorNived, O
dc.contributor.authorRamsey-Goldman, R
dc.contributor.authorKalunian, K
dc.contributor.authorDouglas, J
dc.contributor.authorThompson, K
dc.contributor.authorFarewell, V
dc.date.accessioned2023-02-03T17:45:23Z
dc.date.available2023-02-03T17:45:23Z
dc.identifier.citationHanly JG, Urowitz MB, Sanchez-Guerrero J, Bae SC, Gordon C, Wallace DJ, Isenberg D, Alarcón GS, Clarke A, Bernatsky S, Merrill JT, Petri M, Dooley MA, Gladman D, Fortin PR, Steinsson K, Bruce I, Manzi S, Khamashta M, Zoma A, Aranow C, Ginzler E, Van Vollenhoven R, Font J, Sturfelt G, Nived O, Ramsey-Goldman R, Kalunian K, Douglas J, Thompson K, Farewell V; Systemic Lupus International Collaborating Clinics. Neuropsychiatric events at the time of diagnosis of systemic lupus erythematosus: an international inception cohort study. Arthritis Rheum. 2007 Jan;56(1):265-73. doi: 10.1002/art.22305. PMID: 17195230.en_US
dc.identifier.issn0004-3591
dc.identifier.pmid17195230
dc.identifier.urihttp://hdl.handle.net/20.500.12648/8235
dc.description.abstractTo describe the prevalence, characteristics, attribution, and clinical significance of neuropsychiatric (NP) events in an international inception cohort of systemic lupus erythematosus (SLE) patients.
dc.description.abstractThe study was conducted by the Systemic Lupus International Collaborating Clinics (SLICC). Patients were enrolled within 15 months of fulfilling the American College of Rheumatology (ACR) SLE classification criteria. All NP events within a predefined enrollment window were identified using the ACR case definitions of 19 NP syndromes. Decision rules were derived to determine the proportion of NP disease attributable to SLE. Clinical significance was determined using the Short Form 36 (SF-36) Health Survey and the SLICC/ACR Damage Index (SDI).
dc.description.abstractA total of 572 patients (88% female) were recruited, with a mean +/- SD age of 35 +/- 14 years. The mean +/- SD disease duration was 5.2 +/- 4.2 months. Within the enrollment window, 158 of 572 patients (28%) had at least 1 NP event. In total, there were 242 NP events that encompassed 15 of 19 NP syndromes. The proportion of NP events attributed to SLE varied from 19% to 38% using alternate attribution models and occurred in 6.1-11.7% of patients. Those with NP events, regardless of attribution, had lower scores on the SF-36 and higher SDI scores compared with patients with no NP events.
dc.description.abstractTwenty-eight percent of SLE patients experienced at least 1 NP event around the time of diagnosis of SLE, of which only a minority were attributed to SLE. Regardless of attribution, the occurrence of NP events was associated with reduced quality of life and increased organ damage.
dc.language.isoenen_US
dc.relation.urlhttps://onlinelibrary.wiley.com/doi/epdf/10.1002/art.22305en_US
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.titleNeuropsychiatric events at the time of diagnosis of systemic lupus erythematosus: an international inception cohort study.en_US
dc.typeArticle/Reviewen_US
dc.source.journaltitleArthritis and rheumatismen_US
dc.source.volume56
dc.source.issue1
dc.source.beginpage265
dc.source.endpage73
dc.source.countryUnited Kingdom
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.description.versionVoRen_US
refterms.dateFOA2023-02-03T17:45:23Z
html.description.abstractTo describe the prevalence, characteristics, attribution, and clinical significance of neuropsychiatric (NP) events in an international inception cohort of systemic lupus erythematosus (SLE) patients.
html.description.abstractThe study was conducted by the Systemic Lupus International Collaborating Clinics (SLICC). Patients were enrolled within 15 months of fulfilling the American College of Rheumatology (ACR) SLE classification criteria. All NP events within a predefined enrollment window were identified using the ACR case definitions of 19 NP syndromes. Decision rules were derived to determine the proportion of NP disease attributable to SLE. Clinical significance was determined using the Short Form 36 (SF-36) Health Survey and the SLICC/ACR Damage Index (SDI).
html.description.abstractA total of 572 patients (88% female) were recruited, with a mean +/- SD age of 35 +/- 14 years. The mean +/- SD disease duration was 5.2 +/- 4.2 months. Within the enrollment window, 158 of 572 patients (28%) had at least 1 NP event. In total, there were 242 NP events that encompassed 15 of 19 NP syndromes. The proportion of NP events attributed to SLE varied from 19% to 38% using alternate attribution models and occurred in 6.1-11.7% of patients. Those with NP events, regardless of attribution, had lower scores on the SF-36 and higher SDI scores compared with patients with no NP events.
html.description.abstractTwenty-eight percent of SLE patients experienced at least 1 NP event around the time of diagnosis of SLE, of which only a minority were attributed to SLE. Regardless of attribution, the occurrence of NP events was associated with reduced quality of life and increased organ damage.
dc.description.institutionSUNY Downstateen_US
dc.description.departmentRheumatologyen_US
dc.description.degreelevelN/Aen_US
dc.identifier.journalArthritis and rheumatism


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