Prednisone and azathioprine compared to prednisone plus low-dose azathioprine and cyclophosphamide in the treatment of diffuse lupus nephritis.

Ginzler, E; Diamond, H; Guttadauria, M; Kaplan, D

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Arthritis Rheumatism - July ...

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Author

Ginzler, E
Diamond, H
Guttadauria, M
Kaplan, D

Journal title

Arthritis and rheumatism

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Publication Issue

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693

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http://hdl.handle.net/20.500.12648/8219

Abstract

A 1-year double-blind crossover study comparing prednisone and azathioprine to prednisone plus low-dose azathioprine and cyclophosphamide was carried out in 14 patients with diffuse lupus nephritis. Low-dose triple therapy had no apparent therapeutic advantage over prednisone plus azathioprine. Cyclophosphamide-induced ovarian failure and hematuria were not avoided by its use in low dose.

Citation

Ginzler E, Diamond H, Guttadauria M, Kaplan D. Prednisone and azathioprine compared to prednisone plus low-dose azathioprine and cyclophosphamide in the treatment of diffuse lupus nephritis. Arthritis Rheum. 1976 Jul-Aug;19(4):693-9. doi: 10.1002/1529-0131(197607/08)19:4<693::aid-art1780190406>3.0.co;2-2. PMID: 782464.

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Downstate College of Medicine

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