Priming deficiency in male subjects at risk for alcoholism: the N4 during a lexical decision task.
Average rating
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Star rating
Your vote was cast
Thank you for your feedback
Thank you for your feedback
Author
Roopesh, Bangalore NRangaswamy, Madhavi
Kamarajan, Chella
Chorlian, David B
Stimus, Arthur
Bauer, Lance O
Rohrbaugh, John
O'Connor, Sean J
Kuperman, Samuel
Schuckit, Marc
Porjesz, Bernice
Journal title
Alcoholism, clinical and experimental researchDate Published
2009-09-17Publication Volume
33Publication Issue
12Publication Begin page
2027Publication End page
36
Metadata
Show full item recordAbstract
While there is extensive literature on the relationship between the P3 component of event-related potentials (ERPs) and risk for alcoholism, there are few published studies regarding other potentially important ERP components. One important candidate is the N4(00) component in the context of semantic processing, as abnormalities in this component have been reported for adult alcoholics.A semantic priming task was administered to nonalcohol dependent male offspring (18 to 25 years) of alcoholic fathers [high risk (HR) n = 23] and nonalcoholic fathers [low risk (LR) n = 28] to study whether the 2 groups differ in terms of the N4 component. Subjects were presented with 150 words and 150 nonwords. Among the words, 50 words (primed) were preceded by their antonyms (prime, n = 50), whereas the remaining 50 words were unprimed. For the analysis, N4 amplitude and latency as well as behavioral measures for the primed and unprimed words were considered.
A significant interaction effect was observed between semantic condition and group, where HR subjects did not show N4 attenuation for primed stimuli.
The lack of N4 attenuation to primed stimuli and/or inability to differentiate between primed and unprimed stimuli, without latency and reaction time being affected, suggest deficits in semantic priming, especially in semantic expectancy and/or postlexical semantic processing in HR male offspring. Further, it indicates that it might be an electrophysiological endophenotype that reflects genetic vulnerability to develop alcoholism.
Citation
Roopesh BN, Rangaswamy M, Kamarajan C, Chorlian DB, Stimus A, Bauer LO, Rohrbaugh J, O'Connor SJ, Kuperman S, Schuckit M, Porjesz B. Priming deficiency in male subjects at risk for alcoholism: the N4 during a lexical decision task. Alcohol Clin Exp Res. 2009 Dec;33(12):2027-36. doi: 10.1111/j.1530-0277.2009.01042.x. Epub 2009 Sep 17. PMID: 19764939; PMCID: PMC3601897.DOI
10.1111/j.1530-0277.2009.01042.xae974a485f413a2113503eed53cd6c53
10.1111/j.1530-0277.2009.01042.x
Scopus Count
Collections
The following license files are associated with this item:
- Creative Commons
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivatives 4.0 International