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dc.contributor.authorEdenberg, Howard J
dc.contributor.authorKoller, Daniel L
dc.contributor.authorXuei, Xiaoling
dc.contributor.authorWetherill, Leah
dc.contributor.authorMcClintick, Jeanette N
dc.contributor.authorAlmasy, Laura
dc.contributor.authorBierut, Laura J
dc.contributor.authorBucholz, Kathleen K
dc.contributor.authorGoate, Alison
dc.contributor.authorAliev, Fazil
dc.contributor.authorDick, Danielle
dc.contributor.authorHesselbrock, Victor
dc.contributor.authorHinrichs, Anthony
dc.contributor.authorKramer, John
dc.contributor.authorKuperman, Sam
dc.contributor.authorNurnberger, John I
dc.contributor.authorRice, John P
dc.contributor.authorSchuckit, Marc A
dc.contributor.authorTaylor, Robert
dc.contributor.authorTodd Webb, B
dc.contributor.authorTischfield, Jay A
dc.contributor.authorPorjesz, Bernice
dc.contributor.authorForoud, Tatiana
dc.date.accessioned2023-02-01T20:09:14Z
dc.date.available2023-02-01T20:09:14Z
dc.date.issued2010-03-01
dc.identifier.citationEdenberg HJ, Koller DL, Xuei X, Wetherill L, McClintick JN, Almasy L, Bierut LJ, Bucholz KK, Goate A, Aliev F, Dick D, Hesselbrock V, Hinrichs A, Kramer J, Kuperman S, Nurnberger JI Jr, Rice JP, Schuckit MA, Taylor R, Todd Webb B, Tischfield JA, Porjesz B, Foroud T. Genome-wide association study of alcohol dependence implicates a region on chromosome 11. Alcohol Clin Exp Res. 2010 May;34(5):840-52. doi: 10.1111/j.1530-0277.2010.01156.x. Epub 2010 Mar 1. PMID: 20201924; PMCID: PMC2884073.en_US
dc.identifier.eissn1530-0277
dc.identifier.doi10.1111/j.1530-0277.2010.01156.x
dc.identifier.pmid20201924
dc.identifier.urihttp://hdl.handle.net/20.500.12648/8207
dc.description.abstractAlcohol dependence is a complex disease, and although linkage and candidate gene studies have identified several genes associated with the risk for alcoholism, these explain only a portion of the risk.
dc.description.abstractWe carried out a genome-wide association study (GWAS) on a case-control sample drawn from the families in the Collaborative Study on the Genetics of Alcoholism. The cases all met diagnostic criteria for alcohol dependence according to the Diagnostic and Statistical Manual of Mental Disorders-Fourth Edition; controls all consumed alcohol but were not dependent on alcohol or illicit drugs. To prioritize among the strongest candidates, we genotyped most of the top 199 single nucleotide polymorphisms (SNPs) (p < or = 2.1 x 10(-4)) in a sample of alcohol-dependent families and performed pedigree-based association analysis. We also examined whether the genes harboring the top SNPs were expressed in human brain or were differentially expressed in the presence of ethanol in lymphoblastoid cells.
dc.description.abstractAlthough no single SNP met genome-wide criteria for significance, there were several clusters of SNPs that provided mutual support. Combining evidence from the case-control study, the follow-up in families, and gene expression provided strongest support for the association of a cluster of genes on chromosome 11 (SLC22A18, PHLDA2, NAP1L4, SNORA54, CARS, and OSBPL5) with alcohol dependence. Several SNPs nominated as candidates in earlier GWAS studies replicated in ours, including CPE, DNASE2B, SLC10A2, ARL6IP5, ID4, GATA4, SYNE1, and ADCY3.
dc.description.abstractWe have identified several promising associations that warrant further examination in independent samples.
dc.language.isoenen_US
dc.relation.urlhttps://onlinelibrary.wiley.com/doi/10.1111/j.1530-0277.2010.01156.xen_US
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.titleGenome-wide association study of alcohol dependence implicates a region on chromosome 11.en_US
dc.typeArticle/Reviewen_US
dc.source.journaltitleAlcoholism, clinical and experimental researchen_US
dc.source.volume34
dc.source.issue5
dc.source.beginpage840
dc.source.endpage52
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryEngland
dc.description.versionAMen_US
refterms.dateFOA2023-02-01T20:09:15Z
html.description.abstractAlcohol dependence is a complex disease, and although linkage and candidate gene studies have identified several genes associated with the risk for alcoholism, these explain only a portion of the risk.
html.description.abstractWe carried out a genome-wide association study (GWAS) on a case-control sample drawn from the families in the Collaborative Study on the Genetics of Alcoholism. The cases all met diagnostic criteria for alcohol dependence according to the Diagnostic and Statistical Manual of Mental Disorders-Fourth Edition; controls all consumed alcohol but were not dependent on alcohol or illicit drugs. To prioritize among the strongest candidates, we genotyped most of the top 199 single nucleotide polymorphisms (SNPs) (p < or = 2.1 x 10(-4)) in a sample of alcohol-dependent families and performed pedigree-based association analysis. We also examined whether the genes harboring the top SNPs were expressed in human brain or were differentially expressed in the presence of ethanol in lymphoblastoid cells.
html.description.abstractAlthough no single SNP met genome-wide criteria for significance, there were several clusters of SNPs that provided mutual support. Combining evidence from the case-control study, the follow-up in families, and gene expression provided strongest support for the association of a cluster of genes on chromosome 11 (SLC22A18, PHLDA2, NAP1L4, SNORA54, CARS, and OSBPL5) with alcohol dependence. Several SNPs nominated as candidates in earlier GWAS studies replicated in ours, including CPE, DNASE2B, SLC10A2, ARL6IP5, ID4, GATA4, SYNE1, and ADCY3.
html.description.abstractWe have identified several promising associations that warrant further examination in independent samples.
dc.description.institutionSUNY Downstateen_US
dc.description.departmentHenri Begleiter Neurodynamics Laboratoryen_US
dc.description.degreelevelN/Aen_US
dc.identifier.journalAlcoholism, clinical and experimental research


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