Show simple item record

Predicting sensation seeking from dopamine genes. A candidate-system approach.

dc.contributor.authorDerringer, Jaime
dc.contributor.authorKrueger, Robert F
dc.contributor.authorDick, Danielle M
dc.contributor.authorSaccone, Scott
dc.contributor.authorGrucza, Richard A
dc.contributor.authorAgrawal, Arpana
dc.contributor.authorLin, Peng
dc.contributor.authorAlmasy, Laura
dc.contributor.authorEdenberg, Howard J
dc.contributor.authorForoud, Tatiana
dc.contributor.authorNurnberger, John I
dc.contributor.authorHesselbrock, Victor M
dc.contributor.authorKramer, John R
dc.contributor.authorKuperman, Samuel
dc.contributor.authorPorjesz, Bernice
dc.contributor.authorSchuckit, Marc A
dc.contributor.authorBierut, Laura J
dc.date.accessioned2023-02-01T19:56:24Z
dc.date.available2023-02-01T19:56:24Z
dc.date.issued2010-08-23
dc.identifier.citationDerringer J, Krueger RF, Dick DM, Saccone S, Grucza RA, Agrawal A, Lin P, Almasy L, Edenberg HJ, Foroud T, Nurnberger JI Jr, Hesselbrock VM, Kramer JR, Kuperman S, Porjesz B, Schuckit MA, Bierut LJ; Gene Environment Association Studies (GENEVA) Consortium. Predicting sensation seeking from dopamine genes. A candidate-system approach. Psychol Sci. 2010 Sep;21(9):1282-90. doi: 10.1177/0956797610380699. Epub 2010 Aug 23. PMID: 20732903; PMCID: PMC3031097.en_US
dc.identifier.eissn1467-9280
dc.identifier.doi10.1177/0956797610380699
dc.identifier.pmid20732903
dc.identifier.urihttp://hdl.handle.net/20.500.12648/8205
dc.description.abstractSensation seeking is a heritable personality trait that has been reliably linked to behavioral disorders. The dopamine system has been hypothesized to contribute to variations in sensation seeking between different individuals, and both experimental and observational studies in humans and nonhuman animals provide evidence for the involvement of the dopamine system in sensation-seeking behavior. In this study, we took a candidate-system approach to genetic association analysis of sensation-seeking behavior. We analyzed single-nucleotide polymorphisms (SNPs) from a number of dopaminergic genes. Using 273 SNPs from eight dopamine genes in a sample of 635 unrelated individuals, we examined the aggregate effect of SNPs that were significantly associated with sensation-seeking behavior. Multiple SNPs in four dopamine genes accounted for significant variance in sensation-seeking behavior between individuals. These results suggest that multiple SNPs, aggregated within genes that are relevant to a specific neurobiological system, form a genetic-risk score that may explain a significant proportion of observed variance in human traits such as sensation-seeking behavior.
dc.language.isoenen_US
dc.relation.urlhttps://journals.sagepub.com/doi/10.1177/0956797610380699en_US
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.titlePredicting sensation seeking from dopamine genes. A candidate-system approach.en_US
dc.typeArticle/Reviewen_US
dc.source.journaltitlePsychological scienceen_US
dc.source.volume21
dc.source.issue9
dc.source.beginpage1282
dc.source.endpage90
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.description.versionAMen_US
refterms.dateFOA2023-02-01T19:56:24Z
html.description.abstractSensation seeking is a heritable personality trait that has been reliably linked to behavioral disorders. The dopamine system has been hypothesized to contribute to variations in sensation seeking between different individuals, and both experimental and observational studies in humans and nonhuman animals provide evidence for the involvement of the dopamine system in sensation-seeking behavior. In this study, we took a candidate-system approach to genetic association analysis of sensation-seeking behavior. We analyzed single-nucleotide polymorphisms (SNPs) from a number of dopaminergic genes. Using 273 SNPs from eight dopamine genes in a sample of 635 unrelated individuals, we examined the aggregate effect of SNPs that were significantly associated with sensation-seeking behavior. Multiple SNPs in four dopamine genes accounted for significant variance in sensation-seeking behavior between individuals. These results suggest that multiple SNPs, aggregated within genes that are relevant to a specific neurobiological system, form a genetic-risk score that may explain a significant proportion of observed variance in human traits such as sensation-seeking behavior.
dc.description.institutionSUNY Downstateen_US
dc.description.departmentHenri Begleiter Neurodynamics Laboratoryen_US
dc.description.degreelevelN/Aen_US
dc.identifier.journalPsychological science


Files in this item

Thumbnail
Name:
nihms264820.pdf
Size:
562.4Kb
Format:
PDF
Download

This item appears in the following Collection(s)

Show simple item record

Attribution-NonCommercial-NoDerivatives 4.0 International
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivatives 4.0 International