Predicting sensation seeking from dopamine genes. A candidate-system approach.
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Author
Derringer, JaimeKrueger, Robert F
Dick, Danielle M
Saccone, Scott
Grucza, Richard A
Agrawal, Arpana
Lin, Peng
Almasy, Laura
Edenberg, Howard J
Foroud, Tatiana
Nurnberger, John I
Hesselbrock, Victor M
Kramer, John R
Kuperman, Samuel
Porjesz, Bernice
Schuckit, Marc A
Bierut, Laura J
Journal title
Psychological scienceDate Published
2010-08-23Publication Volume
21Publication Issue
9Publication Begin page
1282Publication End page
90
Metadata
Show full item recordAbstract
Sensation seeking is a heritable personality trait that has been reliably linked to behavioral disorders. The dopamine system has been hypothesized to contribute to variations in sensation seeking between different individuals, and both experimental and observational studies in humans and nonhuman animals provide evidence for the involvement of the dopamine system in sensation-seeking behavior. In this study, we took a candidate-system approach to genetic association analysis of sensation-seeking behavior. We analyzed single-nucleotide polymorphisms (SNPs) from a number of dopaminergic genes. Using 273 SNPs from eight dopamine genes in a sample of 635 unrelated individuals, we examined the aggregate effect of SNPs that were significantly associated with sensation-seeking behavior. Multiple SNPs in four dopamine genes accounted for significant variance in sensation-seeking behavior between individuals. These results suggest that multiple SNPs, aggregated within genes that are relevant to a specific neurobiological system, form a genetic-risk score that may explain a significant proportion of observed variance in human traits such as sensation-seeking behavior.Citation
Derringer J, Krueger RF, Dick DM, Saccone S, Grucza RA, Agrawal A, Lin P, Almasy L, Edenberg HJ, Foroud T, Nurnberger JI Jr, Hesselbrock VM, Kramer JR, Kuperman S, Porjesz B, Schuckit MA, Bierut LJ; Gene Environment Association Studies (GENEVA) Consortium. Predicting sensation seeking from dopamine genes. A candidate-system approach. Psychol Sci. 2010 Sep;21(9):1282-90. doi: 10.1177/0956797610380699. Epub 2010 Aug 23. PMID: 20732903; PMCID: PMC3031097.DOI
10.1177/0956797610380699ae974a485f413a2113503eed53cd6c53
10.1177/0956797610380699
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- Creative Commons
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivatives 4.0 International
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