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dc.contributor.authorBauer, Lance
dc.contributor.authorDick, Danielle
dc.contributor.authorBierut, Laura
dc.contributor.authorBucholz, Kathleen
dc.contributor.authorEdenberg, Howard
dc.contributor.authorKuperman, Samuel
dc.contributor.authorKramer, John
dc.contributor.authorNurnberger, John
dc.contributor.authorO'Connor, Sean
dc.contributor.authorRice, John
dc.contributor.authorRohrbaugh, John
dc.contributor.authorSchuckit, Marc
dc.contributor.authorTischfield, Jay
dc.contributor.authorPorjesz, Bernice
dc.contributor.authorHesselbrock, Victor
dc.date.accessioned2023-02-01T19:48:07Z
dc.date.available2023-02-01T19:48:07Z
dc.identifier.citationBauer L, Dick D, Bierut L, Bucholz K, Edenberg H, Kuperman S, Kramer J, Nurnberger J, O'Connor S, Rice J, Rohrbaugh J, Schuckit M, Tischfield J, Porjesz B, Hesselbrock V. Obesity, smoking, and frontal brain dysfunction. Am J Addict. 2010 Sep-Oct;19(5):391-400. doi: 10.1111/j.1521-0391.2010.00069.x. PMID: 20716301; PMCID: PMC2924769.en_US
dc.identifier.eissn1521-0391
dc.identifier.doi10.1111/j.1521-0391.2010.00069.x
dc.identifier.pmid20716301
dc.identifier.urihttp://hdl.handle.net/20.500.12648/8203
dc.description.abstractObesity, smoking, and conduct problems have all been associated with decrements in brain function. However, their additive and interactive effects have rarely been examined. To address the deficiency, we studied P300a and P300b electroencephalographic potentials in 218 women grouped by the presence versus absence of: (1) a BMI > or = 30 kg/m(2); (2) recent smoking; and (3) > or = 2 childhood conduct problems. Analyses revealed smaller P300a and P300b amplitudes over the posterior scalp among recent smokers versus nonsmokers. No corresponding group differences were found in P300 latencies or frontal scalp amplitudes. The most interesting analysis result was an interaction between conduct problems and obesity limited to the frontally generated P300a component: its latency was significantly greater in women with both attributes than in those with either or neither attribute. An exploratory ANOVA, substituting the genotype of a GABRA2 SNP for conduct problems, also demonstrated an interaction with obesity affecting P300a latency. It is hypothesized that conduct problems, and a conduct-problem-associated GABRA2 genotype, decrease the age-of-onset and/or increase the lifetime duration of obesity. As a result, they may potentiate the adverse effects of obesity on frontal white matter and thereby increase P300a latency. Smoking may affect brain function by a different mechanism to reduce posterior scalp P300a and P300b amplitudes while preserving frontal scalp P300a latency and amplitude.
dc.language.isoenen_US
dc.relation.urlhttps://onlinelibrary.wiley.com/doi/10.1111/j.1521-0391.2010.00069.xen_US
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.titleObesity, smoking, and frontal brain dysfunction.en_US
dc.typeArticle/Reviewen_US
dc.source.journaltitleThe American journal on addictionsen_US
dc.source.volume19
dc.source.issue5
dc.source.beginpage391
dc.source.endpage400
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryEngland
dc.description.versionAMen_US
refterms.dateFOA2023-02-01T19:48:08Z
html.description.abstractObesity, smoking, and conduct problems have all been associated with decrements in brain function. However, their additive and interactive effects have rarely been examined. To address the deficiency, we studied P300a and P300b electroencephalographic potentials in 218 women grouped by the presence versus absence of: (1) a BMI > or = 30 kg/m(2); (2) recent smoking; and (3) > or = 2 childhood conduct problems. Analyses revealed smaller P300a and P300b amplitudes over the posterior scalp among recent smokers versus nonsmokers. No corresponding group differences were found in P300 latencies or frontal scalp amplitudes. The most interesting analysis result was an interaction between conduct problems and obesity limited to the frontally generated P300a component: its latency was significantly greater in women with both attributes than in those with either or neither attribute. An exploratory ANOVA, substituting the genotype of a GABRA2 SNP for conduct problems, also demonstrated an interaction with obesity affecting P300a latency. It is hypothesized that conduct problems, and a conduct-problem-associated GABRA2 genotype, decrease the age-of-onset and/or increase the lifetime duration of obesity. As a result, they may potentiate the adverse effects of obesity on frontal white matter and thereby increase P300a latency. Smoking may affect brain function by a different mechanism to reduce posterior scalp P300a and P300b amplitudes while preserving frontal scalp P300a latency and amplitude.
dc.description.institutionSUNY Downstateen_US
dc.description.departmentHenri Begleiter Neurodynamics Laboratoryen_US
dc.description.degreelevelN/Aen_US
dc.identifier.journalThe American journal on addictions


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