Dysfunctional reward processing in male alcoholics: an ERP study during a gambling task.
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Your vote was cast
Thank you for your feedback
Thank you for your feedback
Chorlian, David B
Pandey, Ashwini K
Roopesh, Bangalore N
Stimus, Arthur T
Journal titleJournal of psychiatric research
Publication Begin page576
Publication End page90
MetadataShow full item record
AbstractA dysfunctional neural reward system has been shown to be associated with alcoholism. The current study aims to examine reward processing in male alcoholics by using event-related potentials (ERPs) as well as behavioral measures of impulsivity and risk-taking.
Outcome-related negativity (ORN/N2) and positivity (ORP/P3) derived from a single outcome gambling task were analyzed using a mixed model procedure. Current density was compared across groups and outcomes using standardized low resolution electromagnetic tomography (sLORETA). Behavioral scores were also compared across groups. Correlations of ERP factors with behavioral and impulsivity factors were also analyzed.
Alcoholics showed significantly lower amplitude than controls during all outcome conditions for the ORP component and decreased amplitude during the loss conditions for the ORN component. Within conditions, gain produced higher amplitudes than loss conditions. Topographically, both groups had an anterior focus during loss conditions and posterior maxima during gain conditions, especially for the ORN component. Decreased ORP current density at cingulate gyrus and less negative ORN current density at sensory and motor areas characterized the alcoholics. Alcoholics had higher levels of impulsivity and risk-taking features than controls.
Deficient outcome/reward processing and increased impulsivity and risk-taking observed in alcoholics may be at least partly due to reward deficiency and/or dysfunctional reward circuitry in the brain, suggesting that alcoholism can be considered as part of the cluster of the reward deficiency syndrome (RDS).
CitationKamarajan C, Rangaswamy M, Tang Y, Chorlian DB, Pandey AK, Roopesh BN, Manz N, Saunders R, Stimus AT, Porjesz B. Dysfunctional reward processing in male alcoholics: an ERP study during a gambling task. J Psychiatr Res. 2010 Jul;44(9):576-90. doi: 10.1016/j.jpsychires.2009.11.019. Epub 2009 Dec 24. PMID: 20035952; PMCID: PMC2878886.
The following license files are associated with this item:
- Creative Commons
Except where otherwise noted, this item's license is described as Copyright 2009 Elsevier Ltd. All rights reserved.
- Reward processing deficits and impulsivity in high-risk offspring of alcoholics: A study of event-related potentials during a monetary gambling task.
- Authors: Kamarajan C, Pandey AK, Chorlian DB, Manz N, Stimus AT, Bauer LO, Hesselbrock VM, Schuckit MA, Kuperman S, Kramer J, Porjesz B
- Issue date: 2015 Nov
- Topography, power, and current source density of θ oscillations during reward processing as markers for alcohol dependence.
- Authors: Kamarajan C, Rangaswamy M, Manz N, Chorlian DB, Pandey AK, Roopesh BN, Porjesz B
- Issue date: 2012 May
- Brain signatures of monetary loss and gain: outcome-related potentials in a single outcome gambling task.
- Authors: Kamarajan C, Porjesz B, Rangaswamy M, Tang Y, Chorlian DB, Padmanabhapillai A, Saunders R, Pandey AK, Roopesh BN, Manz N, Stimus AT, Begleiter H
- Issue date: 2009 Jan 30
- Deficient Event-Related Theta Oscillations in Individuals at Risk for Alcoholism: A Study of Reward Processing and Impulsivity Features.
- Authors: Kamarajan C, Pandey AK, Chorlian DB, Manz N, Stimus AT, Anokhin AP, Bauer LO, Kuperman S, Kramer J, Bucholz KK, Schuckit MA, Hesselbrock VM, Porjesz B
- Issue date: 2015
- Neurocognitive deficits in male alcoholics: an ERP/sLORETA analysis of the N2 component in an equal probability Go/NoGo task.
- Authors: Pandey AK, Kamarajan C, Tang Y, Chorlian DB, Roopesh BN, Manz N, Stimus A, Rangaswamy M, Porjesz B
- Issue date: 2012 Jan