Single-nucleotide polymorphisms in corticotropin releasing hormone receptor 1 gene (CRHR1) are associated with quantitative trait of event-related potential and alcohol dependence.
Average rating
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Star rating
Your vote was cast
Thank you for your feedback
Thank you for your feedback
Author
Chen, Andrew C HManz, Niklas
Tang, Yongqiang
Rangaswamy, Madhavi
Almasy, Laura
Kuperman, Samuel
Nurnberger, John
O'Connor, Sean J
Edenberg, Howard J
Schuckit, Marc A
Tischfield, Jay
Foroud, Tatiana
Bierut, Laura J
Rohrbaugh, John
Rice, John P
Goate, Alison
Hesselbrock, Victor
Porjesz, Bernice
Journal title
Alcoholism, clinical and experimental researchDate Published
2010-04-05Publication Volume
34Publication Issue
6Publication Begin page
988Publication End page
96
Metadata
Show full item recordAbstract
Endophenotypes reflect more proximal effects of genes than diagnostic categories, hence providing a more powerful strategy in searching for genes involved in complex psychiatric disorders. There is strong evidence suggesting the P3 amplitude of the event-related potential (ERP) as an endophenotype for the risk of alcoholism and other disinhibitory disorders. Recent studies demonstrated a crucial role of corticotropin releasing hormone receptor 1 (CRHR1) in the environmental stress response and ethanol self-administration in animal models. The aim of the present study was to test the potential associations between single-nucleotide polymorphisms (SNPs) in the CRHR1 gene and the quantitative trait, P3 amplitude during the processing of visual target signals in an oddball paradigm, as well as alcohol dependence diagnosis.We analyzed a sample from the Collaborative Study on the Genetics of Alcoholism (COGA) comprising 1049 Caucasian subjects from 209 families (including 472 alcohol-dependent individuals). Quantitative transmission disequilibrium test (QTDT) and family-based association test (FBAT) were used to test the association, and false discovery rate (FDR) was applied to correct for multiple comparisons.
Significant associations (p < 0.05) were found between the P3 amplitude and alcohol dependence with multiple SNPs in the CRHR1 gene.
Our results suggest that CRHR1 may be involved in modulating the P3 component of the ERP during information processing and in vulnerability to alcoholism. These findings underscore the utility of electrophysiology and the endophenotype approach in the genetic study of psychiatric disorders.
Citation
Chen AC, Manz N, Tang Y, Rangaswamy M, Almasy L, Kuperman S, Nurnberger J Jr, O'Connor SJ, Edenberg HJ, Schuckit MA, Tischfield J, Foroud T, Bierut LJ, Rohrbaugh J, Rice JP, Goate A, Hesselbrock V, Porjesz B. Single-nucleotide polymorphisms in corticotropin releasing hormone receptor 1 gene (CRHR1) are associated with quantitative trait of event-related potential and alcohol dependence. Alcohol Clin Exp Res. 2010 Jun;34(6):988-96. doi: 10.1111/j.1530-0277.2010.01173.x. Epub 2010 Apr 5. PMID: 20374216; PMCID: PMC3248053.DOI
10.1111/j.1530-0277.2010.01173.xae974a485f413a2113503eed53cd6c53
10.1111/j.1530-0277.2010.01173.x
Scopus Count
Collections
The following license files are associated with this item:
- Creative Commons
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivatives 4.0 International
Related articles
- Association of single nucleotide polymorphisms in a glutamate receptor gene (GRM8) with theta power of event-related oscillations and alcohol dependence.
- Authors: Chen AC, Tang Y, Rangaswamy M, Wang JC, Almasy L, Foroud T, Edenberg HJ, Hesselbrock V, Nurnberger J Jr, Kuperman S, O'Connor SJ, Schuckit MA, Bauer LO, Tischfield J, Rice JP, Bierut L, Goate A, Porjesz B
- Issue date: 2009 Apr 5
- Lack of association between single nucleotide polymorphisms in the corticotropin releasing hormone receptor 1 (CRHR1) gene and alcohol dependence.
- Authors: Dahl JP, Doyle GA, Oslin DW, Buono RJ, Ferraro TN, Lohoff FW, Berrettini WH
- Issue date: 2005 Sep
- What can time-frequency and phase coherence measures tell us about the genetic basis of P3 amplitude?
- Authors: Malone SM, McGue M, Iacono WG
- Issue date: 2017 May
- Prediction of the risk of comorbid alcoholism in schizophrenia by interaction of common genetic variants in the corticotropin-releasing factor system.
- Authors: Ribbe K, Ackermann V, Schwitulla J, Begemann M, Papiol S, Grube S, Sperling S, Friedrichs H, Jahn O, Sillaber I, Gefeller O, Krampe H, Ehrenreich H
- Issue date: 2011 Dec
- Influence of child abuse on adult depression: moderation by the corticotropin-releasing hormone receptor gene.
- Authors: Bradley RG, Binder EB, Epstein MP, Tang Y, Nair HP, Liu W, Gillespie CF, Berg T, Evces M, Newport DJ, Stowe ZN, Heim CM, Nemeroff CB, Schwartz A, Cubells JF, Ressler KJ
- Issue date: 2008 Feb