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dc.contributor.authorDerringer, Jaime
dc.contributor.authorKrueger, Robert F
dc.contributor.authorManz, Niklas
dc.contributor.authorPorjesz, Bernice
dc.contributor.authorAlmasy, Laura
dc.contributor.authorBookman, Ebony
dc.contributor.authorEdenberg, Howard J
dc.contributor.authorKramer, John R
dc.contributor.authorTischfield, Jay A
dc.contributor.authorBierut, Laura J
dc.date.accessioned2023-02-01T19:24:19Z
dc.date.available2023-02-01T19:24:19Z
dc.identifier.citationDerringer J, Krueger RF, Manz N, Porjesz B, Almasy L, Bookman E, Edenberg HJ, Kramer JR, Tischfield JA, Bierut LJ. Nonreplication of an association of SGIP1 SNPs with alcohol dependence and resting theta EEG power. Psychiatr Genet. 2011 Oct;21(5):265-6. doi: 10.1097/YPG.0b013e32834371fd. PMID: 21317682; PMCID: PMC3139721.en_US
dc.identifier.eissn1473-5873
dc.identifier.doi10.1097/YPG.0b013e32834371fd
dc.identifier.pmid21317682
dc.identifier.urihttp://hdl.handle.net/20.500.12648/8196
dc.description.abstractA recent study in a sample of Plains Indians showed association between eight single nucleotide polymorphisms (SNPs) located in the SGIP1 gene and resting θ electroencephalogram (EEG) power. This association appeared to generalize to alcohol use disorders, for which EEG power is a potential endophenotype. We analyzed a large, diverse sample for replication of the association of these implicated SGIP1 SNPs (genotyped on the Illumina 1M platform) with alcohol dependence (N=3988) and θ EEG power (N=1066). We found no evidence of association of the earlier implicated SGIP1 SNPs with either alcohol dependence or θ EEG power (all P>0.15) in this sample. The earlier implicated SNPs located in SGIP1 gene showed no association with alcohol dependence or θ EEG power in this sample of individuals with European and/or African ancestry. This failure to replicate may be the result of differences in ancestry between this sample and the original sample.
dc.language.isoenen_US
dc.relation.urlhttps://journals.lww.com/psychgenetics/Abstract/2011/10000/Nonreplication_of_an_association_of_SGIP1_SNPs.8.aspxen_US
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.titleNonreplication of an association of SGIP1 SNPs with alcohol dependence and resting theta EEG power.en_US
dc.typeArticle/Reviewen_US
dc.source.journaltitlePsychiatric geneticsen_US
dc.source.volume21
dc.source.issue5
dc.source.beginpage265
dc.source.endpage6
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryEngland
dc.description.versionAMen_US
refterms.dateFOA2023-02-01T19:24:19Z
html.description.abstractA recent study in a sample of Plains Indians showed association between eight single nucleotide polymorphisms (SNPs) located in the SGIP1 gene and resting θ electroencephalogram (EEG) power. This association appeared to generalize to alcohol use disorders, for which EEG power is a potential endophenotype. We analyzed a large, diverse sample for replication of the association of these implicated SGIP1 SNPs (genotyped on the Illumina 1M platform) with alcohol dependence (N=3988) and θ EEG power (N=1066). We found no evidence of association of the earlier implicated SGIP1 SNPs with either alcohol dependence or θ EEG power (all P>0.15) in this sample. The earlier implicated SNPs located in SGIP1 gene showed no association with alcohol dependence or θ EEG power in this sample of individuals with European and/or African ancestry. This failure to replicate may be the result of differences in ancestry between this sample and the original sample.
dc.description.institutionSUNY Downstateen_US
dc.description.departmentHenri Begleiter Neurodynamics Laboratoryen_US
dc.description.degreelevelN/Aen_US
dc.identifier.journalPsychiatric genetics


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