Nonreplication of an association of SGIP1 SNPs with alcohol dependence and resting theta EEG power.
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Author
Derringer, JaimeKrueger, Robert F
Manz, Niklas
Porjesz, Bernice
Almasy, Laura
Bookman, Ebony
Edenberg, Howard J
Kramer, John R
Tischfield, Jay A
Bierut, Laura J
Journal title
Psychiatric geneticsPublication Volume
21Publication Issue
5Publication Begin page
265Publication End page
6
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A recent study in a sample of Plains Indians showed association between eight single nucleotide polymorphisms (SNPs) located in the SGIP1 gene and resting θ electroencephalogram (EEG) power. This association appeared to generalize to alcohol use disorders, for which EEG power is a potential endophenotype. We analyzed a large, diverse sample for replication of the association of these implicated SGIP1 SNPs (genotyped on the Illumina 1M platform) with alcohol dependence (N=3988) and θ EEG power (N=1066). We found no evidence of association of the earlier implicated SGIP1 SNPs with either alcohol dependence or θ EEG power (all P>0.15) in this sample. The earlier implicated SNPs located in SGIP1 gene showed no association with alcohol dependence or θ EEG power in this sample of individuals with European and/or African ancestry. This failure to replicate may be the result of differences in ancestry between this sample and the original sample.Citation
Derringer J, Krueger RF, Manz N, Porjesz B, Almasy L, Bookman E, Edenberg HJ, Kramer JR, Tischfield JA, Bierut LJ. Nonreplication of an association of SGIP1 SNPs with alcohol dependence and resting theta EEG power. Psychiatr Genet. 2011 Oct;21(5):265-6. doi: 10.1097/YPG.0b013e32834371fd. PMID: 21317682; PMCID: PMC3139721.DOI
10.1097/YPG.0b013e32834371fdae974a485f413a2113503eed53cd6c53
10.1097/YPG.0b013e32834371fd
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