Genome-wide association study of comorbid depressive syndrome and alcohol dependence.
dc.contributor.author | Edwards, Alexis C | |
dc.contributor.author | Aliev, Fazil | |
dc.contributor.author | Bierut, Laura J | |
dc.contributor.author | Bucholz, Kathleen K | |
dc.contributor.author | Edenberg, Howard | |
dc.contributor.author | Hesselbrock, Victor | |
dc.contributor.author | Kramer, John | |
dc.contributor.author | Kuperman, Samuel | |
dc.contributor.author | Nurnberger, John I | |
dc.contributor.author | Schuckit, Marc A | |
dc.contributor.author | Porjesz, Bernice | |
dc.contributor.author | Dick, Danielle M | |
dc.date.accessioned | 2023-02-01T19:15:59Z | |
dc.date.available | 2023-02-01T19:15:59Z | |
dc.identifier.citation | Edwards AC, Aliev F, Bierut LJ, Bucholz KK, Edenberg H, Hesselbrock V, Kramer J, Kuperman S, Nurnberger JI Jr, Schuckit MA, Porjesz B, Dick DM. Genome-wide association study of comorbid depressive syndrome and alcohol dependence. Psychiatr Genet. 2012 Feb;22(1):31-41. doi: 10.1097/YPG.0b013e32834acd07. PMID: 22064162; PMCID: PMC3241912. | en_US |
dc.identifier.eissn | 1473-5873 | |
dc.identifier.doi | 10.1097/YPG.0b013e32834acd07 | |
dc.identifier.pmid | 22064162 | |
dc.identifier.uri | http://hdl.handle.net/20.500.12648/8193 | |
dc.description.abstract | Depression and alcohol dependence (AD) are common psychiatric disorders that often co-occur. Both disorders are genetically influenced, with heritability estimates in the range of 35-60%. In addition, evidence from twin studies suggests that AD and depression are genetically correlated. Herein, we report results from a genome-wide association study of a comorbid phenotype, in which cases meet the Diagnostic and Statistical Manual of Mental Disorders-IV symptom threshold for major depressive symptomatology and the Diagnostic and Statistical Manual of Mental Disorders-IV criteria for AD. | |
dc.description.abstract | Samples (N=467 cases and N=407 controls) were of European-American descent and were genotyped using the Illumina Human 1M BeadChip array. | |
dc.description.abstract | Although no single-nucleotide polymorphism (SNP) meets genome-wide significance criteria, we identified 10 markers with P values less than 1 × 10(-5), seven of which are located in known genes, which have not been previously implicated in either disorder. Genes harboring SNPs yielding P values less than 1 × 10(-5) are functionally enriched for a number of gene ontology categories, notably several related to glutamatergic function. Investigation of expression localization using online resources suggests that these genes are expressed across a variety of tissues, including behaviorally relevant brain regions. Genes that have been previously associated with depression, AD, or other addiction-related phenotypes - such as CDH13, CSMD2, GRID1, and HTR1B - were implicated by nominally significant SNPs. Finally, the degree of overlap of significant SNPs between a comorbid phenotype and an AD-only phenotype is modest. | |
dc.description.abstract | These results underscore the complex genomic influences on psychiatric phenotypes and suggest that a comorbid phenotype is partially influenced by genetic variants that do not affect AD alone. | |
dc.language.iso | en | en_US |
dc.relation.url | https://journals.lww.com/psychgenetics/Abstract/2012/02000/Genome_wide_association_study_of_comorbid.4.aspx | en_US |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 International | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.title | Genome-wide association study of comorbid depressive syndrome and alcohol dependence. | en_US |
dc.type | Article/Review | en_US |
dc.source.journaltitle | Psychiatric genetics | en_US |
dc.source.volume | 22 | |
dc.source.issue | 1 | |
dc.source.beginpage | 31 | |
dc.source.endpage | 41 | |
dc.source.country | United States | |
dc.source.country | United States | |
dc.source.country | United States | |
dc.source.country | United States | |
dc.source.country | United States | |
dc.source.country | United States | |
dc.source.country | United States | |
dc.source.country | United States | |
dc.source.country | United States | |
dc.source.country | England | |
dc.description.version | AM | en_US |
refterms.dateFOA | 2023-02-01T19:16:00Z | |
html.description.abstract | Depression and alcohol dependence (AD) are common psychiatric disorders that often co-occur. Both disorders are genetically influenced, with heritability estimates in the range of 35-60%. In addition, evidence from twin studies suggests that AD and depression are genetically correlated. Herein, we report results from a genome-wide association study of a comorbid phenotype, in which cases meet the Diagnostic and Statistical Manual of Mental Disorders-IV symptom threshold for major depressive symptomatology and the Diagnostic and Statistical Manual of Mental Disorders-IV criteria for AD. | |
html.description.abstract | Samples (N=467 cases and N=407 controls) were of European-American descent and were genotyped using the Illumina Human 1M BeadChip array. | |
html.description.abstract | Although no single-nucleotide polymorphism (SNP) meets genome-wide significance criteria, we identified 10 markers with P values less than 1 × 10(-5), seven of which are located in known genes, which have not been previously implicated in either disorder. Genes harboring SNPs yielding P values less than 1 × 10(-5) are functionally enriched for a number of gene ontology categories, notably several related to glutamatergic function. Investigation of expression localization using online resources suggests that these genes are expressed across a variety of tissues, including behaviorally relevant brain regions. Genes that have been previously associated with depression, AD, or other addiction-related phenotypes - such as CDH13, CSMD2, GRID1, and HTR1B - were implicated by nominally significant SNPs. Finally, the degree of overlap of significant SNPs between a comorbid phenotype and an AD-only phenotype is modest. | |
html.description.abstract | These results underscore the complex genomic influences on psychiatric phenotypes and suggest that a comorbid phenotype is partially influenced by genetic variants that do not affect AD alone. | |
dc.description.institution | SUNY Downstate | en_US |
dc.description.department | Henri Begleiter Neurodynamics Laboratory | en_US |
dc.description.degreelevel | N/A | en_US |
dc.identifier.journal | Psychiatric genetics |