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dc.contributor.authorEdwards, Alexis C
dc.contributor.authorAliev, Fazil
dc.contributor.authorBierut, Laura J
dc.contributor.authorBucholz, Kathleen K
dc.contributor.authorEdenberg, Howard
dc.contributor.authorHesselbrock, Victor
dc.contributor.authorKramer, John
dc.contributor.authorKuperman, Samuel
dc.contributor.authorNurnberger, John I
dc.contributor.authorSchuckit, Marc A
dc.contributor.authorPorjesz, Bernice
dc.contributor.authorDick, Danielle M
dc.date.accessioned2023-02-01T19:15:59Z
dc.date.available2023-02-01T19:15:59Z
dc.identifier.citationEdwards AC, Aliev F, Bierut LJ, Bucholz KK, Edenberg H, Hesselbrock V, Kramer J, Kuperman S, Nurnberger JI Jr, Schuckit MA, Porjesz B, Dick DM. Genome-wide association study of comorbid depressive syndrome and alcohol dependence. Psychiatr Genet. 2012 Feb;22(1):31-41. doi: 10.1097/YPG.0b013e32834acd07. PMID: 22064162; PMCID: PMC3241912.en_US
dc.identifier.eissn1473-5873
dc.identifier.doi10.1097/YPG.0b013e32834acd07
dc.identifier.pmid22064162
dc.identifier.urihttp://hdl.handle.net/20.500.12648/8193
dc.description.abstractDepression and alcohol dependence (AD) are common psychiatric disorders that often co-occur. Both disorders are genetically influenced, with heritability estimates in the range of 35-60%. In addition, evidence from twin studies suggests that AD and depression are genetically correlated. Herein, we report results from a genome-wide association study of a comorbid phenotype, in which cases meet the Diagnostic and Statistical Manual of Mental Disorders-IV symptom threshold for major depressive symptomatology and the Diagnostic and Statistical Manual of Mental Disorders-IV criteria for AD.
dc.description.abstractSamples (N=467 cases and N=407 controls) were of European-American descent and were genotyped using the Illumina Human 1M BeadChip array.
dc.description.abstractAlthough no single-nucleotide polymorphism (SNP) meets genome-wide significance criteria, we identified 10 markers with P values less than 1 × 10(-5), seven of which are located in known genes, which have not been previously implicated in either disorder. Genes harboring SNPs yielding P values less than 1 × 10(-5) are functionally enriched for a number of gene ontology categories, notably several related to glutamatergic function. Investigation of expression localization using online resources suggests that these genes are expressed across a variety of tissues, including behaviorally relevant brain regions. Genes that have been previously associated with depression, AD, or other addiction-related phenotypes - such as CDH13, CSMD2, GRID1, and HTR1B - were implicated by nominally significant SNPs. Finally, the degree of overlap of significant SNPs between a comorbid phenotype and an AD-only phenotype is modest.
dc.description.abstractThese results underscore the complex genomic influences on psychiatric phenotypes and suggest that a comorbid phenotype is partially influenced by genetic variants that do not affect AD alone.
dc.language.isoenen_US
dc.relation.urlhttps://journals.lww.com/psychgenetics/Abstract/2012/02000/Genome_wide_association_study_of_comorbid.4.aspxen_US
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.titleGenome-wide association study of comorbid depressive syndrome and alcohol dependence.en_US
dc.typeArticle/Reviewen_US
dc.source.journaltitlePsychiatric geneticsen_US
dc.source.volume22
dc.source.issue1
dc.source.beginpage31
dc.source.endpage41
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryEngland
dc.description.versionAMen_US
refterms.dateFOA2023-02-01T19:16:00Z
html.description.abstractDepression and alcohol dependence (AD) are common psychiatric disorders that often co-occur. Both disorders are genetically influenced, with heritability estimates in the range of 35-60%. In addition, evidence from twin studies suggests that AD and depression are genetically correlated. Herein, we report results from a genome-wide association study of a comorbid phenotype, in which cases meet the Diagnostic and Statistical Manual of Mental Disorders-IV symptom threshold for major depressive symptomatology and the Diagnostic and Statistical Manual of Mental Disorders-IV criteria for AD.
html.description.abstractSamples (N=467 cases and N=407 controls) were of European-American descent and were genotyped using the Illumina Human 1M BeadChip array.
html.description.abstractAlthough no single-nucleotide polymorphism (SNP) meets genome-wide significance criteria, we identified 10 markers with P values less than 1 × 10(-5), seven of which are located in known genes, which have not been previously implicated in either disorder. Genes harboring SNPs yielding P values less than 1 × 10(-5) are functionally enriched for a number of gene ontology categories, notably several related to glutamatergic function. Investigation of expression localization using online resources suggests that these genes are expressed across a variety of tissues, including behaviorally relevant brain regions. Genes that have been previously associated with depression, AD, or other addiction-related phenotypes - such as CDH13, CSMD2, GRID1, and HTR1B - were implicated by nominally significant SNPs. Finally, the degree of overlap of significant SNPs between a comorbid phenotype and an AD-only phenotype is modest.
html.description.abstractThese results underscore the complex genomic influences on psychiatric phenotypes and suggest that a comorbid phenotype is partially influenced by genetic variants that do not affect AD alone.
dc.description.institutionSUNY Downstateen_US
dc.description.departmentHenri Begleiter Neurodynamics Laboratoryen_US
dc.description.degreelevelN/Aen_US
dc.identifier.journalPsychiatric genetics


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