Show simple item record

dc.contributor.authorOlfson, Emily
dc.contributor.authorEdenberg, Howard J
dc.contributor.authorNurnberger, John
dc.contributor.authorAgrawal, Arpana
dc.contributor.authorBucholz, Kathleen K
dc.contributor.authorAlmasy, Laura A
dc.contributor.authorChorlian, David
dc.contributor.authorDick, Danielle M
dc.contributor.authorHesselbrock, Victor M
dc.contributor.authorKramer, John R
dc.contributor.authorKuperman, Samuel
dc.contributor.authorPorjesz, Bernice
dc.contributor.authorSchuckit, Marc A
dc.contributor.authorTischfield, Jay A
dc.contributor.authorWang, Jen-Chyong
dc.contributor.authorWetherill, Leah
dc.contributor.authorForoud, Tatiana M
dc.contributor.authorRice, John
dc.contributor.authorGoate, Alison
dc.contributor.authorBierut, Laura J
dc.date.accessioned2023-01-23T20:31:45Z
dc.date.available2023-01-23T20:31:45Z
dc.date.issued2014-09-24
dc.identifier.citationOlfson E, Edenberg HJ, Nurnberger J Jr, Agrawal A, Bucholz KK, Almasy LA, Chorlian D, Dick DM, Hesselbrock VM, Kramer JR, Kuperman S, Porjesz B, Schuckit MA, Tischfield JA, Wang JC, Wetherill L, Foroud TM, Rice J, Goate A, Bierut LJ. An ADH1B variant and peer drinking in progression to adolescent drinking milestones: evidence of a gene-by-environment interaction. Alcohol Clin Exp Res. 2014 Oct;38(10):2541-9. doi: 10.1111/acer.12524. Epub 2014 Sep 24. PMID: 25257461; PMCID: PMC4256939.en_US
dc.identifier.eissn1530-0277
dc.identifier.doi10.1111/acer.12524
dc.identifier.pmid25257461
dc.identifier.urihttp://hdl.handle.net/20.500.12648/8147
dc.description.abstractAdolescent drinking is an important public health concern, one that is influenced by both genetic and environmental factors. The functional variant rs1229984 in alcohol dehydrogenase 1B (ADH1B) has been associated at a genome-wide level with alcohol use disorders in diverse adult populations. However, few data are available regarding whether this variant influences early drinking behaviors and whether social context moderates this effect. This study examines the interplay between rs1229984 and peer drinking in the development of adolescent drinking milestones.
dc.description.abstractOne thousand five hundred and fifty European and African American individuals who had a full drink of alcohol before age 18 were selected from a longitudinal study of youth as part of the Collaborative Study on the Genetics of Alcoholism (COGA). Cox proportional hazards regression, with G × E product terms in the final models, was used to study 2 primary outcomes during adolescence: age of first intoxication and age of first DSM-5 alcohol use disorder symptom.
dc.description.abstractThe minor A allele of rs1229984 was associated with a protective effect for first intoxication (HR = 0.56, 95% CI 0.41 to 0.76) and first DSM-5 symptom (HR = 0.45, 95% CI 0.26 to 0.77) in the final models. Reporting that most or all best friends drink was associated with a hazardous effect for first intoxication (HR = 1.81, 95% CI 1.62 to 2.01) and first DSM-5 symptom (HR = 2.17, 95% 1.88 to 2.50) in the final models. Furthermore, there was a significant G × E interaction for first intoxication (p = 0.002) and first DSM-5 symptom (p = 0.01). Among individuals reporting none or few best friends drinking, the ADH1B variant had a protective effect for adolescent drinking milestones, but for those reporting most or all best friends drinking, this effect was greatly reduced.
dc.description.abstractOur results suggest that the risk factor of best friends drinking attenuates the protective effect of a well-established ADH1B variant for 2 adolescent drinking behaviors. These findings illustrate the interplay between genetic and environmental factors in the development of drinking milestones during adolescence.
dc.language.isoenen_US
dc.relation.urlhttps://onlinelibrary.wiley.com/doi/10.1111/acer.12524en_US
dc.rightsCopyright © 2014 by the Research Society on Alcoholism.
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectAdolescenten_US
dc.subjectAlcohol Dehydrogenaseen_US
dc.subjectGene-Environment Interactionen_US
dc.subjectPeer Drinkingen_US
dc.titleAn ADH1B variant and peer drinking in progression to adolescent drinking milestones: evidence of a gene-by-environment interaction.en_US
dc.typeArticle/Reviewen_US
dc.source.journaltitleAlcoholism, clinical and experimental researchen_US
dc.source.volume38
dc.source.issue10
dc.source.beginpage2541
dc.source.endpage9
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryEngland
dc.description.versionAMen_US
refterms.dateFOA2023-01-23T20:31:46Z
html.description.abstractAdolescent drinking is an important public health concern, one that is influenced by both genetic and environmental factors. The functional variant rs1229984 in alcohol dehydrogenase 1B (ADH1B) has been associated at a genome-wide level with alcohol use disorders in diverse adult populations. However, few data are available regarding whether this variant influences early drinking behaviors and whether social context moderates this effect. This study examines the interplay between rs1229984 and peer drinking in the development of adolescent drinking milestones.
html.description.abstractOne thousand five hundred and fifty European and African American individuals who had a full drink of alcohol before age 18 were selected from a longitudinal study of youth as part of the Collaborative Study on the Genetics of Alcoholism (COGA). Cox proportional hazards regression, with G × E product terms in the final models, was used to study 2 primary outcomes during adolescence: age of first intoxication and age of first DSM-5 alcohol use disorder symptom.
html.description.abstractThe minor A allele of rs1229984 was associated with a protective effect for first intoxication (HR = 0.56, 95% CI 0.41 to 0.76) and first DSM-5 symptom (HR = 0.45, 95% CI 0.26 to 0.77) in the final models. Reporting that most or all best friends drink was associated with a hazardous effect for first intoxication (HR = 1.81, 95% CI 1.62 to 2.01) and first DSM-5 symptom (HR = 2.17, 95% 1.88 to 2.50) in the final models. Furthermore, there was a significant G × E interaction for first intoxication (p = 0.002) and first DSM-5 symptom (p = 0.01). Among individuals reporting none or few best friends drinking, the ADH1B variant had a protective effect for adolescent drinking milestones, but for those reporting most or all best friends drinking, this effect was greatly reduced.
html.description.abstractOur results suggest that the risk factor of best friends drinking attenuates the protective effect of a well-established ADH1B variant for 2 adolescent drinking behaviors. These findings illustrate the interplay between genetic and environmental factors in the development of drinking milestones during adolescence.
dc.description.institutionSUNY Downstateen_US
dc.description.departmentHenri Begleiter Neurodynamics Laboratoryen_US
dc.description.degreelevelN/Aen_US
dc.identifier.journalAlcoholism, clinical and experimental research


Files in this item

Thumbnail
Name:
nihms-636008.pdf
Size:
416.4Kb
Format:
PDF

This item appears in the following Collection(s)

Show simple item record

Copyright © 2014 by the Research Society on Alcoholism.
Except where otherwise noted, this item's license is described as Copyright © 2014 by the Research Society on Alcoholism.