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dc.contributor.authorDick, Danielle M
dc.contributor.authorCho, Seung Bin
dc.contributor.authorLatendresse, Shawn J
dc.contributor.authorAliev, Fazil
dc.contributor.authorNurnberger, John I
dc.contributor.authorEdenberg, Howard J
dc.contributor.authorSchuckit, Marc
dc.contributor.authorHesselbrock, Victor M
dc.contributor.authorPorjesz, Bernice
dc.contributor.authorBucholz, Kathleen
dc.contributor.authorWang, Jen-Chyong
dc.contributor.authorGoate, Alison
dc.contributor.authorKramer, John R
dc.contributor.authorKuperman, Samuel
dc.date.accessioned2023-01-23T20:25:58Z
dc.date.available2023-01-23T20:25:58Z
dc.date.issued2013-05-20
dc.identifier.citationDick DM, Cho SB, Latendresse SJ, Aliev F, Nurnberger JI Jr, Edenberg HJ, Schuckit M, Hesselbrock VM, Porjesz B, Bucholz K, Wang JC, Goate A, Kramer JR, Kuperman S. Genetic influences on alcohol use across stages of development: GABRA2 and longitudinal trajectories of drunkenness from adolescence to young adulthood. Addict Biol. 2014 Nov;19(6):1055-64. doi: 10.1111/adb.12066. Epub 2013 May 20. PMID: 23692184; PMCID: PMC3783626.en_US
dc.identifier.eissn1369-1600
dc.identifier.doi10.1111/adb.12066
dc.identifier.pmid23692184
dc.identifier.urihttp://hdl.handle.net/20.500.12648/8145
dc.description.abstractLongitudinal analyses allow us to understand how genetic risk unfolds across development, in a way that is not possible with cross-sectional analyses of individuals at different ages. This has received little attention in genetic association analyses. In this study, we test for genetic effects of GABRA2, a gene previously associated with alcohol dependence, on trajectories of drunkenness from age 14 to 25. We use data from 1070 individuals who participated in the prospective sample of the Collaborative Study on the Genetics of Alcoholism, in order to better understand the unfolding of genetic risk across development. Piecewise linear growth models were fit to model the influence of genotype on rate of increase in drunkenness from early adolescence to young adulthood (14-18 years), the change in drunkenness during the transition to adulthood (18-19 years) and the rate of change in drunkenness across young adulthood (≥ 19 years). Variation in GABRA2 was associated with an increase in drunkenness that occurred at the transition between adolescence and adulthood. The genotypic effect was more pronounced in females. These analyses illustrate the importance of longitudinal data to characterize how genetic effects unfold across development. The findings suggest that transitions across important developmental periods may alter the relative importance of genetic effects on patterns of alcohol use. The findings also suggest the importance of considering gender when evaluating genetic effects on drinking patterns in males and females.
dc.language.isoenen_US
dc.relation.urlhttps://onlinelibrary.wiley.com/doi/10.1111/adb.12066en_US
dc.rights© 2013 Society for the Study of Addiction.
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectAlcoholen_US
dc.subjectCOGAen_US
dc.subjectGABRA2en_US
dc.subjectgenetic associationen_US
dc.subjectlongitudinalen_US
dc.subjecttrajectoriesen_US
dc.titleGenetic influences on alcohol use across stages of development: GABRA2 and longitudinal trajectories of drunkenness from adolescence to young adulthood.en_US
dc.typeArticle/Reviewen_US
dc.source.journaltitleAddiction biologyen_US
dc.source.volume19
dc.source.issue6
dc.source.beginpage1055
dc.source.endpage64
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.description.versionAMen_US
refterms.dateFOA2023-01-23T20:25:59Z
html.description.abstractLongitudinal analyses allow us to understand how genetic risk unfolds across development, in a way that is not possible with cross-sectional analyses of individuals at different ages. This has received little attention in genetic association analyses. In this study, we test for genetic effects of GABRA2, a gene previously associated with alcohol dependence, on trajectories of drunkenness from age 14 to 25. We use data from 1070 individuals who participated in the prospective sample of the Collaborative Study on the Genetics of Alcoholism, in order to better understand the unfolding of genetic risk across development. Piecewise linear growth models were fit to model the influence of genotype on rate of increase in drunkenness from early adolescence to young adulthood (14-18 years), the change in drunkenness during the transition to adulthood (18-19 years) and the rate of change in drunkenness across young adulthood (≥ 19 years). Variation in GABRA2 was associated with an increase in drunkenness that occurred at the transition between adolescence and adulthood. The genotypic effect was more pronounced in females. These analyses illustrate the importance of longitudinal data to characterize how genetic effects unfold across development. The findings suggest that transitions across important developmental periods may alter the relative importance of genetic effects on patterns of alcohol use. The findings also suggest the importance of considering gender when evaluating genetic effects on drinking patterns in males and females.
dc.description.institutionSUNY Downstateen_US
dc.description.departmentHenri Begleiter Neurodynamics Laboratoryen_US
dc.description.degreelevelN/Aen_US
dc.identifier.journalAddiction biology


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© 2013 Society for the Study of Addiction.
Except where otherwise noted, this item's license is described as © 2013 Society for the Study of Addiction.