Association of substance dependence phenotypes in the COGA sample.
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Author
Wetherill, LeahAgrawal, Arpana
Kapoor, Manav
Bertelsen, Sarah
Bierut, Laura J
Brooks, Andrew
Dick, Danielle
Hesselbrock, Michie
Hesselbrock, Victor
Koller, Daniel L
Le, Nhung
Nurnberger, John I
Salvatore, Jessica E
Schuckit, Marc
Tischfield, Jay A
Wang, Jen-Chyong
Xuei, Xiaoling
Edenberg, Howard J
Porjesz, Bernice
Bucholz, Kathleen
Goate, Alison M
Foroud, Tatiana
Keyword
Alcohol dependencecannabis dependence
cocaine dependence
common genetic liability
drug dependence
opioid dependence
Journal title
Addiction biologyDate Published
2014-05-16Publication Volume
20Publication Issue
3Publication Begin page
617Publication End page
27
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Show full item recordAbstract
Alcohol and drug use disorders are individually heritable (50%). Twin studies indicate that alcohol and substance use disorders share common genetic influences, and therefore may represent a more heritable form of addiction and thus be more powerful for genetic studies. This study utilized data from 2322 subjects from 118 European-American families in the Collaborative Study on the Genetics of Alcoholism sample to conduct genome-wide association analysis of a binary and a continuous index of general substance dependence liability. The binary phenotype (ANYDEP) was based on meeting lifetime criteria for any DSM-IV dependence on alcohol, cannabis, cocaine or opioids. The quantitative trait (QUANTDEP) was constructed from factor analysis based on endorsement across the seven DSM-IV criteria for each of the four substances. Heritability was estimated to be 54% for ANYDEP and 86% for QUANTDEP. One single-nucleotide polymorphism (SNP), rs2952621 in the uncharacterized gene LOC151121 on chromosome 2, was associated with ANYDEP (P = 1.8 × 10(-8) ), with support from surrounding imputed SNPs and replication in an independent sample [Study of Addiction: Genetics and Environment (SAGE); P = 0.02]. One SNP, rs2567261 in ARHGAP28 (Rho GTPase-activating protein 28), was associated with QUANTDEP (P = 3.8 × 10(-8) ), and supported by imputed SNPs in the region, but did not replicate in an independent sample (SAGE; P = 0.29). The results of this study provide evidence that there are common variants that contribute to the risk for a general liability to substance dependence.Citation
Wetherill L, Agrawal A, Kapoor M, Bertelsen S, Bierut LJ, Brooks A, Dick D, Hesselbrock M, Hesselbrock V, Koller DL, Le N, Nurnberger JI Jr, Salvatore JE, Schuckit M, Tischfield JA, Wang JC, Xuei X, Edenberg HJ, Porjesz B, Bucholz K, Goate AM, Foroud T. Association of substance dependence phenotypes in the COGA sample. Addict Biol. 2015 May;20(3):617-27. doi: 10.1111/adb.12153. Epub 2014 May 16. PMID: 24832863; PMCID: PMC4233207.DOI
10.1111/adb.12153ae974a485f413a2113503eed53cd6c53
10.1111/adb.12153
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Except where otherwise noted, this item's license is described as © 2014 Society for the Study of Addiction.
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