Polygenic risk for externalizing disorders: Gene-by-development and gene-by-environment effects in adolescents and young adults.
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AuthorSalvatore, Jessica E
Schuckit, Marc A
Edenberg, Howard J
Foroud, Tatiana M
Dick, Danielle M
KeywordCollaborative Study on the Genetics of Alcoholism (COGA)
Journal titleClinical psychological science : a journal of the Association for Psychological Science
Publication Begin page189
Publication End page201
MetadataShow full item record
AbstractIn this project, we aimed to bring large-scale gene identification findings into a developmental psychopathology framework. Using a family-based sample, we tested whether polygenic scores for externalizing disorders-based on single nucleotide polymorphism weights derived from genome-wide association study results in adults (n = 1,249)-predicted externalizing disorders, subclinical externalizing behavior, and impulsivity-related traits adolescents (n = 248) and young adults (n = 207), and whether parenting and peer factors in adolescence moderated polygenic risk to predict externalizing disorders. Polygenic scores predicted externalizing disorders in adolescents and young adults, even after controlling for parental externalizing disorder history. Polygenic scores also predicted subclinical externalizing behavior and impulsivity traits in the adolescents and young adults. Adolescent parental monitoring and peer substance use moderated polygenic scores to predict externalizing disorders. This illustrates how state of the science genetics can be integrated with psychological science to identify how genetic risk contributes to the development of psychopathology.
CitationSalvatore JE, Aliev F, Bucholz K, Agrawal A, Hesselbrock V, Hesselbrock M, Bauer L, Kuperman S, Schuckit MA, Kramer J, Edenberg HJ, Foroud TM, Dick DM. Polygenic risk for externalizing disorders: Gene-by-development and gene-by-environment effects in adolescents and young adults. Clin Psychol Sci. 2015 Mar;3(2):189-201. doi: 10.1177/2167702614534211. PMID: 25821660; PMCID: PMC4371857.
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