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Further Analyses of Genetic Association Between GRM8 and Alcohol Dependence Symptoms Among Young Adults.

dc.contributor.authorLong, Elizabeth C
dc.contributor.authorAliev, Fazil
dc.contributor.authorWang, Jen-Chyong
dc.contributor.authorEdenberg, Howard J
dc.contributor.authorNurnberger, John
dc.contributor.authorHesselbrock, Victor
dc.contributor.authorPorjesz, Bernice
dc.contributor.authorDick, Danielle M
dc.date.accessioned2023-01-23T20:08:05Z
dc.date.available2023-01-23T20:08:05Z
dc.identifier.citationLong EC, Aliev F, Wang JC, Edenberg HJ, Nurnberger J Jr, Hesselbrock V, Porjesz B, Dick DM. Further Analyses of Genetic Association Between GRM8 and Alcohol Dependence Symptoms Among Young Adults. J Stud Alcohol Drugs. 2015 May;76(3):414-8. doi: 10.15288/jsad.2015.76.414. PMID: 25978827; PMCID: PMC4440299.en_US
dc.identifier.eissn1938-4114
dc.identifier.pmid25978827
dc.identifier.urihttp://hdl.handle.net/20.500.12648/8139
dc.description.abstractThe gene GRM8, a metabotropic glutamate receptor, has emerged as a gene of interest for its possible role in the development of alcohol dependence, with evidence of association with an electrophysiological endophenotype and level of response to alcohol as well as suggestive evidence of association with alcohol dependence.
dc.description.abstractThe present study further investigated the association between GRM8 and alcohol dependence symptom counts among young adults using a new sample of individuals collected as part of the prospective sample (ages 18-26 years; N = 842) from the Collaborative Study on the Genetics of Alcoholism (COGA).
dc.description.abstractTwo single-nucleotide polymorphisms were significantly associated with alcohol dependence in European Americans using the Nyholt corrected p value of .007: rs886003 (β = -.212, p = .0002) and rs17862325 (β = -.234, p < .0001), but not in African Americans, likely because of the lower power to detect association in this group.
dc.description.abstractThese results further implicate the role of glutamate receptor genes such as GRM8 in the development of alcohol dependence.
dc.language.isoenen_US
dc.relation.urlhttps://www.jsad.com/doi/abs/10.15288/jsad.2015.76.414en_US
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.titleFurther Analyses of Genetic Association Between GRM8 and Alcohol Dependence Symptoms Among Young Adults.en_US
dc.typeArticle/Reviewen_US
dc.source.journaltitleJournal of studies on alcohol and drugsen_US
dc.source.volume76
dc.source.issue3
dc.source.beginpage414
dc.source.endpage8
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.description.versionVoRen_US
refterms.dateFOA2023-01-23T20:08:06Z
html.description.abstractThe gene GRM8, a metabotropic glutamate receptor, has emerged as a gene of interest for its possible role in the development of alcohol dependence, with evidence of association with an electrophysiological endophenotype and level of response to alcohol as well as suggestive evidence of association with alcohol dependence.
html.description.abstractThe present study further investigated the association between GRM8 and alcohol dependence symptom counts among young adults using a new sample of individuals collected as part of the prospective sample (ages 18-26 years; N = 842) from the Collaborative Study on the Genetics of Alcoholism (COGA).
html.description.abstractTwo single-nucleotide polymorphisms were significantly associated with alcohol dependence in European Americans using the Nyholt corrected p value of .007: rs886003 (β = -.212, p = .0002) and rs17862325 (β = -.234, p < .0001), but not in African Americans, likely because of the lower power to detect association in this group.
html.description.abstractThese results further implicate the role of glutamate receptor genes such as GRM8 in the development of alcohol dependence.
dc.description.institutionSUNY Downstateen_US
dc.description.departmentHenri Begleiter Neurodynamics Laboratoryen_US
dc.description.degreelevelN/Aen_US
dc.identifier.journalJournal of studies on alcohol and drugs


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