Genes associated with alcohol outcomes show enrichment of effects with broad externalizing and impulsivity phenotypes in an independent sample.

Aliev, Fazil; Wetherill, Leah; Bierut, Laura; Bucholz, Kathleen K; Edenberg, Howard; Foroud, Tatiana; Dick, Danielle M

dc.contributor.author	Aliev, Fazil
dc.contributor.author	Wetherill, Leah
dc.contributor.author	Bierut, Laura
dc.contributor.author	Bucholz, Kathleen K
dc.contributor.author	Edenberg, Howard
dc.contributor.author	Foroud, Tatiana
dc.contributor.author	Dick, Danielle M
dc.date.accessioned	2023-01-23T19:59:15Z
dc.date.available	2023-01-23T19:59:15Z
dc.identifier.citation	Aliev F, Wetherill L, Bierut L, Bucholz KK, Edenberg H, Foroud T; COGA Investigators; Dick DM. Genes associated with alcohol outcomes show enrichment of effects with broad externalizing and impulsivity phenotypes in an independent sample. J Stud Alcohol Drugs. 2015 Jan;76(1):38-46. PMID: 25486392; PMCID: PMC4263779.	en_US
dc.identifier.eissn	1938-4114
dc.identifier.pmid	25486392
dc.identifier.uri	http://hdl.handle.net/20.500.12648/8136
dc.description.abstract	The purpose of this study was to evaluate evidence for association with a panel of genes previously associated with alcohol-related traits in a new sample of adolescent and young adult individuals (N = 2,128; 51% female) collected as part of the Collaborative Study on the Genetics of Alcoholism (COGA). We tested for association with phenotypes related to externalizing behavior, including diagnostic symptom counts for disorders on the externalizing spectrum (alcohol dependence, conduct disorder, adult antisocial personality disorder, and illicit drug dependence), and related behavioral/personality traits (Achenbach Externalizing, NEO Extraversion, NEO Conscientiousness, Zuckerman's Sensation Seeking, and the Barratt Impulsivity Scale) based on the substantial literature suggesting that these behaviors may be alternate manifestations of a shared genetic liability.
dc.description.abstract	We tested for overall enrichment of the set of 215 genotyped single-nucleotide polymorphisms (SNPs) for each of the phenotypes. We conducted secondary analyses comparing results for sensation seeking with results for the other phenotypes.
dc.description.abstract	For all phenotypes, there was significant enrichment of association results (p < .05) compared with chance expectations. The greatest number of significant results was observed with the phenotype Sensation Seeking. Secondary analyses indicated that the number of SNPs yielding p < .05 with Sensation Seeking was significantly greater than that observed for each of the other phenotypes.
dc.description.abstract	We find evidence for enrichment of association results across a spectrum of externalizing phenotypes with a panel of candidate genes/SNPs selected based on previous suggestion of association with alcohol-related outcomes. In particular, we find significant enrichment of effects with sensation seeking, suggesting that this may be a particularly salient behavior associated with risk for alcohol-related problems.
dc.language.iso	en	en_US
dc.relation.url	https://www.jsad.com/doi/epdf/10.15288/jsad.2015.76.38?role=tab	en_US
dc.rights	Attribution-NonCommercial-NoDerivatives 4.0 International	*
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/4.0/	*
dc.title	Genes associated with alcohol outcomes show enrichment of effects with broad externalizing and impulsivity phenotypes in an independent sample.	en_US
dc.type	Article/Review	en_US
dc.source.journaltitle	Journal of studies on alcohol and drugs	en_US
dc.source.volume	76
dc.source.issue	1
dc.source.beginpage	38
dc.source.endpage	46
dc.source.country	United States
dc.source.country	United States
dc.source.country	United States
dc.source.country	United States
dc.source.country	United States
dc.description.version	VoR	en_US
refterms.dateFOA	2023-01-23T19:59:15Z
html.description.abstract	The purpose of this study was to evaluate evidence for association with a panel of genes previously associated with alcohol-related traits in a new sample of adolescent and young adult individuals (N = 2,128; 51% female) collected as part of the Collaborative Study on the Genetics of Alcoholism (COGA). We tested for association with phenotypes related to externalizing behavior, including diagnostic symptom counts for disorders on the externalizing spectrum (alcohol dependence, conduct disorder, adult antisocial personality disorder, and illicit drug dependence), and related behavioral/personality traits (Achenbach Externalizing, NEO Extraversion, NEO Conscientiousness, Zuckerman's Sensation Seeking, and the Barratt Impulsivity Scale) based on the substantial literature suggesting that these behaviors may be alternate manifestations of a shared genetic liability.
html.description.abstract	We tested for overall enrichment of the set of 215 genotyped single-nucleotide polymorphisms (SNPs) for each of the phenotypes. We conducted secondary analyses comparing results for sensation seeking with results for the other phenotypes.
html.description.abstract	For all phenotypes, there was significant enrichment of association results (p < .05) compared with chance expectations. The greatest number of significant results was observed with the phenotype Sensation Seeking. Secondary analyses indicated that the number of SNPs yielding p < .05 with Sensation Seeking was significantly greater than that observed for each of the other phenotypes.
html.description.abstract	We find evidence for enrichment of association results across a spectrum of externalizing phenotypes with a panel of candidate genes/SNPs selected based on previous suggestion of association with alcohol-related outcomes. In particular, we find significant enrichment of effects with sensation seeking, suggesting that this may be a particularly salient behavior associated with risk for alcohol-related problems.
dc.description.institution	SUNY Downstate	en_US
dc.description.department	Henri Begleiter Neurodynamics Laboratory	en_US
dc.description.degreelevel	N/A	en_US
dc.identifier.journal	Journal of studies on alcohol and drugs