Genes associated with alcohol outcomes show enrichment of effects with broad externalizing and impulsivity phenotypes in an independent sample.
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Your vote was cast
Thank you for your feedback
Thank you for your feedback
Bucholz, Kathleen K
Dick, Danielle M
Journal titleJournal of studies on alcohol and drugs
Publication Begin page38
Publication End page46
MetadataShow full item record
AbstractThe purpose of this study was to evaluate evidence for association with a panel of genes previously associated with alcohol-related traits in a new sample of adolescent and young adult individuals (N = 2,128; 51% female) collected as part of the Collaborative Study on the Genetics of Alcoholism (COGA). We tested for association with phenotypes related to externalizing behavior, including diagnostic symptom counts for disorders on the externalizing spectrum (alcohol dependence, conduct disorder, adult antisocial personality disorder, and illicit drug dependence), and related behavioral/personality traits (Achenbach Externalizing, NEO Extraversion, NEO Conscientiousness, Zuckerman's Sensation Seeking, and the Barratt Impulsivity Scale) based on the substantial literature suggesting that these behaviors may be alternate manifestations of a shared genetic liability.
We tested for overall enrichment of the set of 215 genotyped single-nucleotide polymorphisms (SNPs) for each of the phenotypes. We conducted secondary analyses comparing results for sensation seeking with results for the other phenotypes.
For all phenotypes, there was significant enrichment of association results (p < .05) compared with chance expectations. The greatest number of significant results was observed with the phenotype Sensation Seeking. Secondary analyses indicated that the number of SNPs yielding p < .05 with Sensation Seeking was significantly greater than that observed for each of the other phenotypes.
We find evidence for enrichment of association results across a spectrum of externalizing phenotypes with a panel of candidate genes/SNPs selected based on previous suggestion of association with alcohol-related outcomes. In particular, we find significant enrichment of effects with sensation seeking, suggesting that this may be a particularly salient behavior associated with risk for alcohol-related problems.
CitationAliev F, Wetherill L, Bierut L, Bucholz KK, Edenberg H, Foroud T; COGA Investigators; Dick DM. Genes associated with alcohol outcomes show enrichment of effects with broad externalizing and impulsivity phenotypes in an independent sample. J Stud Alcohol Drugs. 2015 Jan;76(1):38-46. PMID: 25486392; PMCID: PMC4263779.
The following license files are associated with this item:
- Creative Commons
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivatives 4.0 International
- How phenotype and developmental stage affect the genes we find: GABRA2 and impulsivity.
- Authors: Dick DM, Aliev F, Latendresse S, Porjesz B, Schuckit M, Rangaswamy M, Hesselbrock V, Edenberg H, Nurnberger J, Agrawal A, Bierut L, Wang J, Bucholz K, Kuperman S, Kramer J
- Issue date: 2013 Jun
- Using dimensional models of externalizing psychopathology to aid in gene identification.
- Authors: Dick DM, Aliev F, Wang JC, Grucza RA, Schuckit M, Kuperman S, Kramer J, Hinrichs A, Bertelsen S, Budde JP, Hesselbrock V, Porjesz B, Edenberg HJ, Bierut LJ, Goate A
- Issue date: 2008 Mar
- Family transmission and heritability of externalizing disorders: a twin-family study.
- Authors: Hicks BM, Krueger RF, Iacono WG, McGue M, Patrick CJ
- Issue date: 2004 Sep
- A Family-Based Genome Wide Association Study of Externalizing Behaviors.
- Authors: Barr PB, Salvatore JE, Wetherill L, Anokhin A, Chan G, Edenberg HJ, Kuperman S, Meyers J, Nurnberger J, Porjesz B, Schuckit M, Dick DM
- Issue date: 2020 May
- Prediction of alcohol use disorder using personality disorder traits: a twin study.
- Authors: Rosenström T, Torvik FA, Ystrom E, Czajkowski NO, Gillespie NA, Aggen SH, Krueger RF, Kendler KS, Reichborn-Kjennerud T
- Issue date: 2018 Jan