Associations Between Cannabis Use, Polygenic Liability for Schizophrenia, and Cannabis-related Experiences in a Sample of Cannabis Users.
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Your vote was cast
Thank you for your feedback
Thank you for your feedback
AuthorJohnson, Emma C
Colbert, Sarah M C
Jeffries, Paul W
Bigdeli, Tim B
Karcher, Nicole R
Meyers, Jacquelyn L
Nurnberger, John I
Plawecki, Martin H
Martin, Nicholas G
Schuckit, Marc A
Murray, Robin M
Dick, Danielle M
Edenberg, Howard J
D'Souza, Deepak Cyril
Di Forti, Marta
Nelson, Elliot C
Journal titleSchizophrenia bulletin
MetadataShow full item record
AbstractRisk for cannabis use and schizophrenia is influenced in part by genetic factors, and there is evidence that genetic risk for schizophrenia is associated with subclinical psychotic-like experiences (PLEs). Few studies to date have examined whether genetic risk for schizophrenia is associated with cannabis-related PLEs.
We tested whether measures of cannabis involvement and polygenic risk scores (PRS) for schizophrenia were associated with self-reported cannabis-related experiences in a sample ascertained for alcohol use disorders (AUDs), the Collaborative Study on the Genetics of Alcoholism (COGA). We analyzed 4832 subjects (3128 of European ancestry and 1704 of African ancestry; 42% female; 74% meeting lifetime criteria for an AUD).
Cannabis use disorder (CUD) was prevalent in this analytic sample (70%), with 40% classified as mild, 25% as moderate, and 35% as severe. Polygenic risk for schizophrenia was positively associated with cannabis-related paranoia, feeling depressed or anhedonia, social withdrawal, and cognitive difficulties, even when controlling for duration of daily cannabis use, CUD, and age at first cannabis use. The schizophrenia PRS was most robustly associated with cannabis-related cognitive difficulties (β = 0.22, SE = 0.04, P = 5.2e-7). In an independent replication sample (N = 1446), associations between the schizophrenia PRS and cannabis-related experiences were in the expected direction and not statistically different in magnitude from those in the COGA sample.
Among individuals who regularly use cannabis, genetic liability for schizophrenia-even in those without clinical features-may increase the likelihood of reporting unusual experiences related to cannabis use.
CitationJohnson EC, Colbert SMC, Jeffries PW, Tillman R, Bigdeli TB, Karcher NR, Chan G, Kuperman S, Meyers JL, Nurnberger JI, Plawecki MH, Degenhardt L, Martin NG, Kamarajan C, Schuckit MA, Murray RM, Dick DM, Edenberg HJ, D'Souza DC, Di Forti M, Porjesz B, Nelson EC, Agrawal A. Associations Between Cannabis Use, Polygenic Liability for Schizophrenia, and Cannabis-related Experiences in a Sample of Cannabis Users. Schizophr Bull. 2022 Dec 21:sbac196. doi: 10.1093/schbul/sbac196. Epub ahead of print. PMID: 36545904.
The following license files are associated with this item:
- Creative Commons
Except where otherwise noted, this item's license is described as © The Author(s) 2022. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center.
- Psychosocial moderation of polygenic risk for cannabis involvement: the role of trauma exposure and frequency of religious service attendance.
- Authors: Meyers JL, Salvatore JE, Aliev F, Johnson EC, McCutcheon VV, Su J, Kuo SI, Lai D, Wetherill L, Wang JC, Chan G, Hesselbrock V, Foroud T, Bucholz KK, Edenberg HJ, Dick DM, Porjesz B, Agrawal A
- Issue date: 2019 Oct 21
- No evidence of associations between genetic liability for schizophrenia and development of cannabis use disorder.
- Authors: Hjorthøj C, Uddin MJ, Wimberley T, Dalsgaard S, Hougaard DM, Børglum A, Werge T, Nordentoft M
- Issue date: 2021 Feb
- Exploring the relationship between polygenic risk for cannabis use, peer cannabis use and the longitudinal course of cannabis involvement.
- Authors: Johnson EC, Tillman R, Aliev F, Meyers JL, Salvatore JE, Anokhin AP, Dick DM, Edenberg HJ, Kramer JR, Kuperman S, McCutcheon VV, Nurnberger JI Jr, Porjesz B, Schuckit MA, Tischfield J, Bucholz KK, Agrawal A
- Issue date: 2019 Apr
- Short communication: Genetic association between schizophrenia and cannabis use.
- Authors: Verweij KJ, Abdellaoui A, Nivard MG, Sainz Cort A, Ligthart L, Draisma HH, Minică CC, International Cannabis Consortium, Gillespie NA, Willemsen G, Hottenga JJ, Boomsma DI, Vink JM
- Issue date: 2017 Feb 1
- Polygenic Risk Score Prediction of Alcohol Dependence Symptoms Across Population-Based and Clinically Ascertained Samples.
- Authors: Savage JE, Salvatore JE, Aliev F, Edwards AC, Hickman M, Kendler KS, Macleod J, Latvala A, Loukola A, Kaprio J, Rose RJ, Chan G, Hesselbrock V, Webb BT, Adkins A, Bigdeli TB, Riley BP, Dick DM
- Issue date: 2018 Mar