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dc.contributor.authorLegge, Alexandra
dc.contributor.authorKirkland, Susan
dc.contributor.authorRockwood, Kenneth
dc.contributor.authorAndreou, Pantelis
dc.contributor.authorBae, Sang-Cheol
dc.contributor.authorGordon, Caroline
dc.contributor.authorRomero-Diaz, Juanita
dc.contributor.authorSanchez-Guerrero, Jorge
dc.contributor.authorWallace, Daniel J
dc.contributor.authorBernatsky, Sasha
dc.contributor.authorClarke, Ann E
dc.contributor.authorMerrill, Joan T
dc.contributor.authorGinzler, Ellen M
dc.contributor.authorFortin, Paul R
dc.contributor.authorGladman, Dafna D
dc.contributor.authorUrowitz, Murray B
dc.contributor.authorBruce, Ian N
dc.contributor.authorIsenberg, David A
dc.contributor.authorRahman, Anisur
dc.contributor.authorAlarcón, Graciela S
dc.contributor.authorPetri, Michelle
dc.contributor.authorKhamashta, Munther A
dc.contributor.authorDooley, M A
dc.contributor.authorRamsey-Goldman, Rosalind
dc.contributor.authorManzi, Susan
dc.contributor.authorZoma, Asad A
dc.contributor.authorAranow, Cynthia
dc.contributor.authorMackay, Meggan
dc.contributor.authorRuiz-Irastorza, Guillermo
dc.contributor.authorLim, S Sam
dc.contributor.authorInanc, Murat
dc.contributor.authorvan Vollenhoven, Ronald F
dc.contributor.authorJonsen, Andreas
dc.contributor.authorNived, Ola
dc.contributor.authorRamos-Casals, Manuel
dc.contributor.authorKamen, Diane L
dc.contributor.authorKalunian, Kenneth C
dc.contributor.authorJacobsen, Soren
dc.contributor.authorPeschken, Christine A
dc.contributor.authorAskanase, Anca
dc.contributor.authorHanly, John G
dc.date.accessioned2023-01-11T20:12:39Z
dc.date.available2023-01-11T20:12:39Z
dc.date.issued2020-02-12
dc.identifier.citationLegge A, Kirkland S, Rockwood K, Andreou P, Bae SC, Gordon C, Romero-Diaz J, Sanchez-Guerrero J, Wallace DJ, Bernatsky S, Clarke AE, Merrill JT, Ginzler EM, Fortin PR, Gladman DD, Urowitz MB, Bruce IN, Isenberg DA, Rahman A, Alarcón GS, Petri M, Khamashta MA, Dooley MA, Ramsey-Goldman R, Manzi S, Zoma AA, Aranow C, Mackay M, Ruiz-Irastorza G, Lim SS, Inanc M, van Vollenhoven RF, Jonsen A, Nived O, Ramos-Casals M, Kamen DL, Kalunian KC, Jacobsen S, Peschken CA, Askanase A, Hanly JG. Prediction of Damage Accrual in Systemic Lupus Erythematosus Using the Systemic Lupus International Collaborating Clinics Frailty Index. Arthritis Rheumatol. 2020 Apr;72(4):658-666. doi: 10.1002/art.41144. Epub 2020 Feb 12. PMID: 31631584; PMCID: PMC7113092.en_US
dc.identifier.eissn2326-5205
dc.identifier.doi10.1002/art.41144
dc.identifier.pmid31631584
dc.identifier.urihttp://hdl.handle.net/20.500.12648/8095
dc.description.abstractThe Systemic Lupus International Collaborating Clinics (SLICC) frailty index (FI) has been shown to predict mortality, but its association with other important outcomes is unknown. We examined the association of baseline SLICC FI values with damage accrual in the SLICC inception cohort.
dc.description.abstractThe baseline visit was defined as the first visit at which both organ damage (SLICC/American College of Rheumatology Damage Index [SDI]) and health-related quality of life (Short Form 36) were assessed. Baseline SLICC FI scores were calculated. Damage accrual was measured by the increase in SDI between the baseline assessment and the last study visit. Multivariable negative binomial regression was used to estimate the association between baseline SLICC FI values and the rate of increase in the SDI during follow-up, adjusting for relevant demographic and clinical characteristics.
dc.description.abstractThe 1,549 systemic lupus erythematosus (SLE) patients eligible for this analysis were mostly female (88.7%) with a mean ± SD age of 35.7 ± 13.3 years and a median disease duration of 1.2 years (interquartile range 0.9-1.5 years) at baseline. The mean ± SD baseline SLICC FI was 0.17 ± 0.08. Over a mean ± SD follow-up of 7.2 ± 3.7 years, 653 patients (42.2%) had an increase in SDI. Higher baseline SLICC FI values (per 0.05 increase) were associated with higher rates of increase in the SDI during follow-up (incidence rate ratio [IRR] 1.19 [95% confidence interval 1.13-1.25]), after adjusting for age, sex, ethnicity/region, education, baseline SLE Disease Activity Index 2000, baseline SDI, and baseline use of glucocorticoids, antimalarials, and immunosuppressive agents.
dc.description.abstractOur findings indicate that the SLICC FI predicts damage accrual in incident SLE, which further supports the SLICC FI as a valid health measure in SLE.
dc.language.isoenen_US
dc.relation.urlhttps://onlinelibrary.wiley.com/doi/10.1002/art.41144en_US
dc.rights© 2019, American College of Rheumatology.
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.titlePrediction of Damage Accrual in Systemic Lupus Erythematosus Using the Systemic Lupus International Collaborating Clinics Frailty Index.en_US
dc.typeArticle/Reviewen_US
dc.source.journaltitleArthritis & rheumatology (Hoboken, N.J.)en_US
dc.source.volume72
dc.source.issue4
dc.source.beginpage658
dc.source.endpage666
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryCanada
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited Kingdom
dc.source.countryUnited States
dc.description.versionAMen_US
refterms.dateFOA2023-01-11T20:12:40Z
html.description.abstractThe Systemic Lupus International Collaborating Clinics (SLICC) frailty index (FI) has been shown to predict mortality, but its association with other important outcomes is unknown. We examined the association of baseline SLICC FI values with damage accrual in the SLICC inception cohort.
html.description.abstractThe baseline visit was defined as the first visit at which both organ damage (SLICC/American College of Rheumatology Damage Index [SDI]) and health-related quality of life (Short Form 36) were assessed. Baseline SLICC FI scores were calculated. Damage accrual was measured by the increase in SDI between the baseline assessment and the last study visit. Multivariable negative binomial regression was used to estimate the association between baseline SLICC FI values and the rate of increase in the SDI during follow-up, adjusting for relevant demographic and clinical characteristics.
html.description.abstractThe 1,549 systemic lupus erythematosus (SLE) patients eligible for this analysis were mostly female (88.7%) with a mean ± SD age of 35.7 ± 13.3 years and a median disease duration of 1.2 years (interquartile range 0.9-1.5 years) at baseline. The mean ± SD baseline SLICC FI was 0.17 ± 0.08. Over a mean ± SD follow-up of 7.2 ± 3.7 years, 653 patients (42.2%) had an increase in SDI. Higher baseline SLICC FI values (per 0.05 increase) were associated with higher rates of increase in the SDI during follow-up (incidence rate ratio [IRR] 1.19 [95% confidence interval 1.13-1.25]), after adjusting for age, sex, ethnicity/region, education, baseline SLE Disease Activity Index 2000, baseline SDI, and baseline use of glucocorticoids, antimalarials, and immunosuppressive agents.
html.description.abstractOur findings indicate that the SLICC FI predicts damage accrual in incident SLE, which further supports the SLICC FI as a valid health measure in SLE.
dc.description.institutionSUNY Downstateen_US
dc.description.departmentRheumatologyen_US
dc.description.degreelevelN/Aen_US
dc.identifier.journalArthritis & rheumatology (Hoboken, N.J.)


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© 2019, American College of Rheumatology.
Except where otherwise noted, this item's license is described as © 2019, American College of Rheumatology.