Show simple item record

dc.contributor.authorChew, Christine
dc.contributor.authorReynolds, John A
dc.contributor.authorLertratanakul, Apinya
dc.contributor.authorWu, Peggy
dc.contributor.authorUrowitz, Murray
dc.contributor.authorGladman, Dafna D
dc.contributor.authorFortin, Paul R
dc.contributor.authorBae, Sang-Cheol
dc.contributor.authorGordon, Caroline
dc.contributor.authorClarke, Ann E
dc.contributor.authorBernatsky, Sasha
dc.contributor.authorHanly, John G
dc.contributor.authorIsenberg, David
dc.contributor.authorRahman, Anisur
dc.contributor.authorSanchez-Guerrero, Jorge
dc.contributor.authorRomero-Diaz, Juanita
dc.contributor.authorMerrill, Joan
dc.contributor.authorWallace, Daniel
dc.contributor.authorGinzler, Ellen
dc.contributor.authorKhamashta, Munther
dc.contributor.authorNived, Ola
dc.contributor.authorJönsen, Andreas
dc.contributor.authorSteinsson, Kristjan
dc.contributor.authorManzi, Susan
dc.contributor.authorKalunian, Ken
dc.contributor.authorDooley, Mary Anne
dc.contributor.authorPetri, Michelle
dc.contributor.authorAranow, Cynthia
dc.contributor.authorvan Vollenhoven, Ronald
dc.contributor.authorStoll, Thomas
dc.contributor.authorAlarcón, Graciela S
dc.contributor.authorLim, S Sam
dc.contributor.authorRuiz-Irastorza, Guillermo
dc.contributor.authorPeschken, Christine A
dc.contributor.authorAskanase, Anca D
dc.contributor.authorKamen, Diane L
dc.contributor.authorİnanç, Murat
dc.contributor.authorRamsey-Goldman, Rosalind
dc.contributor.authorBruce, Ian N
dc.date.accessioned2023-01-11T19:34:33Z
dc.date.available2023-01-11T19:34:33Z
dc.identifier.citationChew C, Reynolds JA, Lertratanakul A, Wu P, Urowitz M, Gladman DD, Fortin PR, Bae SC, Gordon C, Clarke AE, Bernatsky S, Hanly JG, Isenberg D, Rahman A, Sanchez-Guerrero J, Romero-Diaz J, Merrill J, Wallace D, Ginzler E, Khamashta M, Nived O, Jönsen A, Steinsson K, Manzi S, Kalunian K, Dooley MA, Petri M, Aranow C, van Vollenhoven R, Stoll T, Alarcón GS, Lim SS, Ruiz-Irastorza G, Peschken CA, Askanase AD, Kamen DL, İnanç M, Ramsey-Goldman R, Bruce IN. Lower vitamin D is associated with metabolic syndrome and insulin resistance in systemic lupus: data from an international inception cohort. Rheumatology (Oxford). 2021 Oct 2;60(10):4737-4747. doi: 10.1093/rheumatology/keab090. PMID: 33555325; PMCID: PMC8487307.en_US
dc.identifier.eissn1462-0332
dc.identifier.doi10.1093/rheumatology/keab090
dc.identifier.pmid33555325
dc.identifier.urihttp://hdl.handle.net/20.500.12648/8092
dc.description.abstractVitamin D (25(OH)D) deficiency and metabolic syndrome (MetS) may both contribute to increased cardiovascular risk in SLE. We aimed to examine the association of demographic factors, SLE phenotype, therapy and vitamin D levels with MetS and insulin resistance.
dc.description.abstractThe Systemic Lupus International Collaborating Clinics (SLICC) enrolled patients recently diagnosed with SLE (<15 months) from 33 centres across 11 countries from 2000. Clinical, laboratory and therapeutic data were collected. Vitamin D level was defined according to tertiles based on distribution across this cohort, which were set at T1 (10-36 nmol/l), T2 (37-60 nmol/l) and T3 (61-174 nmol/l). MetS was defined according to the 2009 consensus statement from the International Diabetes Federation. Insulin resistance was determined using the HOMA-IR model. Linear and logistic regressions were used to assess the association of variables with vitamin D levels.
dc.description.abstractOf the 1847 patients, 1163 (63%) had vitamin D measured and 398 (34.2%) subjects were in the lowest 25(OH)D tertile. MetS was present in 286 of 860 (33%) patients whose status could be determined. Patients with lower 25(OH)D were more likely to have MetS and higher HOMA-IR. The MetS components, hypertension, hypertriglyceridemia and decreased high-density lipoprotein (HDL) were all significantly associated with lower 25(OH)D. Increased average glucocorticoid exposure was associated with higher insulin resistance.
dc.description.abstractMetS and insulin resistance are associated with lower vitamin D in patients with SLE. Further studies could determine whether vitamin D repletion confers better control of these cardiovascular risk factors and improve long-term outcomes in SLE.
dc.language.isoenen_US
dc.relation.urlhttps://academic.oup.com/rheumatology/article/60/10/4737/6130830en_US
dc.rights© The Author(s) 2021. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For permissions, please email: journals.permissions@oup.com.
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectcardiovascular diseaseen_US
dc.subjectepidemiologyen_US
dc.subjectsystemic lupus erythematosusen_US
dc.subjectvitamin Den_US
dc.titleLower vitamin D is associated with metabolic syndrome and insulin resistance in systemic lupus: data from an international inception cohort.en_US
dc.typeArticle/Reviewen_US
dc.source.journaltitleRheumatology (Oxford, England)en_US
dc.source.volume60
dc.source.issue10
dc.source.beginpage4737
dc.source.endpage4747
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryCanada
dc.source.countryUnited States
dc.source.countryUnited Kingdom
dc.source.countryEngland
dc.description.versionVoRen_US
refterms.dateFOA2023-01-11T19:34:34Z
html.description.abstractVitamin D (25(OH)D) deficiency and metabolic syndrome (MetS) may both contribute to increased cardiovascular risk in SLE. We aimed to examine the association of demographic factors, SLE phenotype, therapy and vitamin D levels with MetS and insulin resistance.
html.description.abstractThe Systemic Lupus International Collaborating Clinics (SLICC) enrolled patients recently diagnosed with SLE (<15 months) from 33 centres across 11 countries from 2000. Clinical, laboratory and therapeutic data were collected. Vitamin D level was defined according to tertiles based on distribution across this cohort, which were set at T1 (10-36 nmol/l), T2 (37-60 nmol/l) and T3 (61-174 nmol/l). MetS was defined according to the 2009 consensus statement from the International Diabetes Federation. Insulin resistance was determined using the HOMA-IR model. Linear and logistic regressions were used to assess the association of variables with vitamin D levels.
html.description.abstractOf the 1847 patients, 1163 (63%) had vitamin D measured and 398 (34.2%) subjects were in the lowest 25(OH)D tertile. MetS was present in 286 of 860 (33%) patients whose status could be determined. Patients with lower 25(OH)D were more likely to have MetS and higher HOMA-IR. The MetS components, hypertension, hypertriglyceridemia and decreased high-density lipoprotein (HDL) were all significantly associated with lower 25(OH)D. Increased average glucocorticoid exposure was associated with higher insulin resistance.
html.description.abstractMetS and insulin resistance are associated with lower vitamin D in patients with SLE. Further studies could determine whether vitamin D repletion confers better control of these cardiovascular risk factors and improve long-term outcomes in SLE.
dc.description.institutionSUNY Downstateen_US
dc.description.departmentRheumatologyen_US
dc.description.degreelevelN/Aen_US
dc.identifier.journalRheumatology (Oxford, England)


Files in this item

Thumbnail
Name:
keab090.pdf
Size:
561.5Kb
Format:
PDF

This item appears in the following Collection(s)

Show simple item record

© The Author(s) 2021. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For permissions, please email: journals.permissions@oup.com.
Except where otherwise noted, this item's license is described as © The Author(s) 2021. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For permissions, please email: journals.permissions@oup.com.