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dc.contributor.authorAlmeida-Brasil, Celline C
dc.contributor.authorHanly, John G
dc.contributor.authorUrowitz, Murray
dc.contributor.authorClarke, Ann Elaine
dc.contributor.authorRuiz-Irastorza, Guillermo
dc.contributor.authorGordon, Caroline
dc.contributor.authorRamsey-Goldman, Rosalind
dc.contributor.authorPetri, Michelle A
dc.contributor.authorGinzler, Ellen M
dc.contributor.authorWallace, Daniel J
dc.contributor.authorBae, Sang-Cheol
dc.contributor.authorRomero-Diaz, Juanita
dc.contributor.authorDooley, Mary-Anne
dc.contributor.authorPeschken, Christine
dc.contributor.authorIsenberg, David
dc.contributor.authorRahman, Anisur
dc.contributor.authorManzi, Susan
dc.contributor.authorJacobsen, Søren
dc.contributor.authorLim, S Sam
dc.contributor.authorvan Vollenhoven, Ronald
dc.contributor.authorNived, Ola
dc.contributor.authorJönsen, Andreas
dc.contributor.authorKamen, Diane L
dc.contributor.authorAranow, Cynthia
dc.contributor.authorSánchez-Guerrero, Jorge
dc.contributor.authorGladman, Dafna D
dc.contributor.authorFortin, Paul R
dc.contributor.authorAlarcon, Graciela S
dc.contributor.authorMerrill, Joan T
dc.contributor.authorKalunian, Kenneth
dc.contributor.authorRamos-Casals, Manuel
dc.contributor.authorSteinsson, Kristjan
dc.contributor.authorZoma, A
dc.contributor.authorAskanase, Anca D
dc.contributor.authorKhamashta, Munther
dc.contributor.authorBruce, Ian N
dc.contributor.authorInanc, Murat
dc.contributor.authorLukusa, Luck
dc.contributor.authorBernatsky, Sasha
dc.date.accessioned2023-01-11T19:20:57Z
dc.date.available2023-01-11T19:20:57Z
dc.identifier.citationAlmeida-Brasil CC, Hanly JG, Urowitz M, Clarke AE, Ruiz-Irastorza G, Gordon C, Ramsey-Goldman R, Petri MA, Ginzler EM, Wallace DJ, Bae SC, Romero-Diaz J, Dooley MA, Peschken C, Isenberg D, Rahman A, Manzi S, Jacobsen S, Lim SS, van Vollenhoven R, Nived O, Jönsen A, Kamen DL, Aranow C, Sánchez-Guerrero J, Gladman DD, Fortin PR, Alarcon GS, Merrill JT, Kalunian K, Ramos-Casals M, Steinsson K, Zoma A, Askanase AD, Khamashta M, Bruce IN, Inanc M, Lukusa L, Bernatsky S. Retinal toxicity in a multinational inception cohort of patients with systemic lupus on hydroxychloroquine. Lupus Sci Med. 2022 Nov;9(1):e000789. doi: 10.1136/lupus-2022-000789. PMID: 36396267; PMCID: PMC9677013.en_US
dc.identifier.issn2053-8790
dc.identifier.doi10.1136/lupus-2022-000789
dc.identifier.pmid36396267
dc.identifier.urihttp://hdl.handle.net/20.500.12648/8088
dc.description.abstractTo evaluate hydroxychloroquine (HCQ)-related retinal toxicity in the Systemic Lupus International Collaborating Clinics (SLICC) inception cohort.
dc.description.abstractData were collected at annual study visits between 1999 and 2019. We followed patients with incident SLE from first visit on HCQ (time zero) up to time of retinal toxicity (outcome), death, loss-to-follow-up or end of study. Potential retinal toxicity was identified from SLICC Damage Index scores; cases were confirmed with chart review. Using cumulative HCQ duration as the time axis, we constructed univariate Cox regression models to assess if covariates (ie, HCQ daily dose/kg, sex, race/ethnicity, age at SLE onset, education, body mass index, renal damage, chloroquine use) were associated with HCQ-related retinal toxicity.
dc.description.abstractWe studied 1460 patients (89% female, 52% white). Retinal toxicity was confirmed in 11 patients (incidence 1.0 per 1000 person-years, 0.8% overall). Average cumulative time on HCQ in those with retinal toxicity was 7.4 (SD 3.2) years; the first case was detected 4 years after HCQ initiation. Risk of retinal toxicity was numerically higher in older patients at SLE diagnosis (univariate HR 1.05, 95% CI 1.01 to 1.09).
dc.description.abstractThis is the first assessment of HCQ and retinal disease in incident SLE. We did not see any cases of retinopathy within the first 4 years of HCQ. Cumulative HCQ may be associated with increased risk. Ophthalmology monitoring (and formal assessment of cases of potential toxicity, by a retinal specialist) remains important, especially in patients on HCQ for 10+ years, those needing higher doses and those of older age at SLE diagnosis.
dc.language.isoenen_US
dc.relation.urlhttps://lupus.bmj.com/content/9/1/e000789.longen_US
dc.rights© Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY. Published by BMJ.
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectepidemiologyen_US
dc.subjectlupus erythematosus, systemicen_US
dc.subjectoutcome assessment, health careen_US
dc.titleRetinal toxicity in a multinational inception cohort of patients with systemic lupus on hydroxychloroquine.en_US
dc.typeArticle/Reviewen_US
dc.source.journaltitleLupus science & medicineen_US
dc.source.volume9
dc.source.issue1
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited Kingdom
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryCanada
dc.source.countryUnited States
dc.source.countryUnited Kingdom
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited Kingdom
dc.source.countryEngland
dc.description.versionVoRen_US
refterms.dateFOA2023-01-11T19:20:58Z
html.description.abstractTo evaluate hydroxychloroquine (HCQ)-related retinal toxicity in the Systemic Lupus International Collaborating Clinics (SLICC) inception cohort.
html.description.abstractData were collected at annual study visits between 1999 and 2019. We followed patients with incident SLE from first visit on HCQ (time zero) up to time of retinal toxicity (outcome), death, loss-to-follow-up or end of study. Potential retinal toxicity was identified from SLICC Damage Index scores; cases were confirmed with chart review. Using cumulative HCQ duration as the time axis, we constructed univariate Cox regression models to assess if covariates (ie, HCQ daily dose/kg, sex, race/ethnicity, age at SLE onset, education, body mass index, renal damage, chloroquine use) were associated with HCQ-related retinal toxicity.
html.description.abstractWe studied 1460 patients (89% female, 52% white). Retinal toxicity was confirmed in 11 patients (incidence 1.0 per 1000 person-years, 0.8% overall). Average cumulative time on HCQ in those with retinal toxicity was 7.4 (SD 3.2) years; the first case was detected 4 years after HCQ initiation. Risk of retinal toxicity was numerically higher in older patients at SLE diagnosis (univariate HR 1.05, 95% CI 1.01 to 1.09).
html.description.abstractThis is the first assessment of HCQ and retinal disease in incident SLE. We did not see any cases of retinopathy within the first 4 years of HCQ. Cumulative HCQ may be associated with increased risk. Ophthalmology monitoring (and formal assessment of cases of potential toxicity, by a retinal specialist) remains important, especially in patients on HCQ for 10+ years, those needing higher doses and those of older age at SLE diagnosis.
dc.description.institutionSUNY Downstateen_US
dc.description.departmentRheumatologyen_US
dc.description.degreelevelN/Aen_US
dc.identifier.journalLupus science & medicine


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© Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY. Published by BMJ.
Except where otherwise noted, this item's license is described as © Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY. Published by BMJ.